Percutaneous penetration enhancers physical methods in penetration enhancement. (2017)

• Record Type: Book
• Further Information: Note: Nina Dragicevic, Howard I. Maibach, editors.
• Editors: Dragicevic, Nina; Maibach, Howard I
• Contents: Preface; Contents; Contributors; Part I: Sonophoresis in Penetration Enhancement; 1: Sonophoresis: Ultrasound- Mediated Transdermal Drug Delivery; 1.1 Introduction; 1.2 Ultrasound and Sonophoresis; 1.3 Low-Frequency Sonophoresis; 1.4 Low-Frequency Sonophoresis: Choice of Parameters; 1.5 Mechanism of Low-ƯFrequency Sonophoresis; 1.6 Permeation Pathways of Low-Frequency Sonophoresis; 1.7 Macromolecular Delivery; 1.7.1 Peptides and Proteins; 1.7.2 Low-Molecular-Weight Heparin; 1.7.3 Oligonucleotides; 1.7.4 Vaccines; 1.8 Clinical Studies. 1.9 Transdermal Extraction of Analytes Using Sonophoresis1.10 Safety of Low-Frequency Ultrasound; References; 2: The Mechanism of Sonophoresis and the Penetration Pathways; 2.1 Introduction; 2.2 Mechanism of Sonophoresis; 2.2.1 Thermal Effect; 2.2.2 Cavitation Effect; 2.2.2.1 Stable Cavitation; 2.2.2.2 Inertial Cavitation; 2.3 Penetration Pathways Induced by Sonophoresis; 2.3.1 Pathways Through Hair Follicles; 2.3.2 Penetration Pathways Through the Stratum Corneum; 2.3.3 Transcellular Pathways. 2.4 Synergistic Effect of Low-ƯFrequency Sonophoresis and Other Enhancers for Transdermal Drug Delivery2.5 Factors Affecting Drug Delivery by Low-Frequency Sonophoresis; 2.6 Therapeutic Application of Sonophoresis; 2.6.1 Noninvasive Transdermal Monitoring; 2.6.2 Sonophoresis in Transcutaneous Immunization and Gene Therapy; 2.6.3 Safety Issues and Commercial Devices; References; 3: Therapeutic Applications of Sonophoresis and Sonophoretic Devices; 3.1 Introduction; 3.2 Ultrasound; 3.3 Advantages and Drawbacks of Sonophoresis; 3.4 Therapeutic Applications of ULS; 3.4.1 Drug Release. 3.4.1.1 Topical/Transdermal Drug Release3.4.1.2 Ocular Drug Delivery; 3.4.1.3 Nail Delivery; 3.4.2 Gene Delivery; 3.5 Sonophoretic Devices; 3.5.1 Sonophoretic Systems Available in the Market; 3.5.1.1 Patch-Cap, U-Strip, U-Wand, and A-Wand Systems; Sonoderm Technology; SonoLysis; SonoPrep® Skin Permeation System; 3.5.2 Combination of Sonophoretic Systems with Other Enhancing Technologies; 3.5.2.1 ULS and Chemical Penetration Enhancers; 3.5.2.2 ULS and Iontophoresis; 3.5.2.3 ULS and Microneedles; 3.5.2.4 ULS and Nanocarriers; References. Part II: Iontophoresis in Penetration Enhancement4: Iontophoresis: Basic Principles; 4.1 Introduction; 4.2 Chronology: From First Reports to Recent Discoveries; 4.3 Application Sites Other than the Skin; References; 5: Iontophoretic Transport Mechanisms and Factors Affecting Electrically Assisted Delivery; 5.1 Introduction; 5.2 Factors Influencing Electrically Assisted Drug Delivery; 5.2.1 Current Density; 5.2.2 Formulation; 5.2.2.1 Drug Concentration; 5.2.2.2 pH; 5.2.3 Delivery System; References; 6: Iontophoresis for Therapeutic Drug Delivery and Non-invasive Sampling Applications.
• Publisher Details: Berlin, Germany : Springer
• Publication Date: 2017
• Extent: 1 online resource (xvii, 508 pages), illustrations (some color)
• Subjects: 615.7/78; Dermatologic agents -- Absorption and adsorption; Drug delivery systems; MEDICAL -- Pharmacology; Dermatologic agents -- Absorption and adsorption; Drug delivery systems; Administration, Cutaneous; Electronic books
• Languages: English
• ISBNs: 9783662532737; 3662532735
• Related ISBNs: 9783662532713; 3662532719
• Notes: Note: Includes bibliographical references at the end of each chapters and index.; Note: Online resource; title from PDF title page (SpringerLink, viewed May 11, 2017).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.