Inflammatory mechanisms in mediating hearing loss. ([2018])

• Record Type: Book
• Further Information: Note: Vickram Ramkumar, Leonard P. Rybak, editors.
• Editors: Ramkumar, Vickram; Rybak, Leonard P
• Contents: Intro; Preface; Contents; Contributors; Chapter 1: The Cochlea; 1 Fluid Spaces intheCochlea; 2 Cochlear Duct; 3 Tectorial Membrane; 4 Basilar Membrane; 5 The Lateral Wall oftheCochlea; 6 The Spiral Ligament; 7 Stria Vascularis; Basal Cells; 8 Endocochlear Potential; 9 Organ ofCorti; 10 Mechano-transduction; 11 Hair Cell Synapses; References; Chapter 2: Oxidative Stress andHearing Loss; 1 Introduction; 2 Oxidative Stress; Free Radicals; Oxidative Stress andCytotoxicity; 3 Cochlear Targets ofOxidative Stress; Sensory Epithelium; Lateral Wall; Modiolus. 4 Oxidative Stress inAcquired Hearing LossEnvironmental Exposures; Therapeutic Drugs andAgents; Aging; 5 Interventional Approaches andChallenges; Biomarkers ofOxidative Stress; Otoprotection by Targeting Oxidative Stress; Potential Interference withCell Signaling andDrug Activity; References; Chapter 3: Corticotropin Releasing Factor Signaling intheMammalian Cochlea: AnIntegrative Niche forCochlear Homeostatic Balance Against Noise; 1 Introduction; The Evolution ofHypotheses ConcerningNoise-Induced Hearing Loss. 2 Bounds Related toCurrent Perspectives ofNoise-Induced Damage andFunctional Loss: Cellular Elements ofCochleaTemporary Threshold Shifts (TTS) andAssociated Cellular Elements atRisk forDamage; Previously Described Protective Mechanisms Against NIHL; 3 Elements ofCorticotropin Releasing Factor (Hormone) Signaling Systems, andTheir Expression intheMammalian Inner Ear; A Novel Theory ofLocal Cochlear Signaling Systems Protective AgainstCellular Damage andAssociated NIHL; 4 Inflammatory/Immune Responses intheCochlea Are Driven byAcoustic Over-Exposure. CRF Signaling Is Involved withtheInflammatory Process5 Local (Cochlear) CRF Signaling VersusSystemic HPA Axis: ATale ofTiming, Balance ofMechanistic Actions, andDirect VersusIndirect Signaling; The Indirect CRF Signaling System; The Direct CRF Signaling System, andIts Potential Role inCochlear Function andProtection fromNoise-Induced Damage; 6 Of Glucocorticoids, Clocks, Entrainment, andaPotential Interaction BetweenSystemic andPeripheral CRF Signaling Systems Important forInflammatory Responses intheCochlea; Glucocorticoid Function; Glucocorticoid Receptors. Physiological OscillationsThe Master Clock oftheSuprachiasmatic Nucleus; Peripheral Clocks; 7 A Confluence ofBiological Disciplines That Includes Circadian Biology, Immunology, andCochlear Molecular Neurobiology Converge toSuggest aRole forCochlear CRF Signaling inModulating Inflammatory Responses intheCochlea; A Theory ofCochlear Inflammatory Response toTraumatic Noise Would Include theFollowing Aspects ofSignaling; 8 Conclusions; References; Chapter 4: Cochlear Vascular Pathology andHearing Loss; 1 Introduction; 2 Blood Supply totheLateral Wall.
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2018
• Copyright Date: 2018
• Extent: 1 online resource
• Subjects: 617.8; Deafness; MEDICAL -- Surgery -- General; Deafness; Electronic books
• Languages: English
• ISBNs: 9783319925073; 3319925075
• Related ISBNs: 9783319925066; 3319925067
• Notes: Note: Includes bibliographical references and index.; Note: Vendor-supplied metadata.
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• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.