Cerebral ischemic reperfusion injuries (CIRI) : bench research and clinical implications /: bench research and clinical implications. (2018)

• Record Type: Book
• Further Information: Note: Weijian Jiang, Wengui Yu, Yan Qu, Zhongsong Shi, Benyan Luo, John H. Zhang, editors.
• Editors: Jiang, Weijian; Yu, Wengui; Qu, Yan; Shi, Zhongsong; Luo, Benyan; Zhang, J. H (John H.)
• Contents: Intro; Preface; Introduction; Recanalization-Related Injury; Safety andEfficacy ofLate Recanalization; The Application ofNew Imaging Technique andStrategies; The Characteristics ofPosterior Circulation Stroke; The Immune Regulation andStroke; The Cerebral Venous System andStroke; Contents; About the Editors; Chapter 1: Gelatinase-ƯMediated Impairment ofMicrovascular Beds inCerebral Ischemia andReperfusion Injury; 1 Introduction; 2 Microvascular Beds andtheExtracellular Matrix (ECM); 3 Gelatinases Mediate Impairment ofMicrovascular Beds inCIRI. 4 Activation ofGelatinases andExtravasation oftPA intoBrain Parenchyma inCIRI-Induced Microvascular Bed Damage5 Early Inhibition ofGelatinases May Escalate Neuroprotection andExtend thetPA Therapeutic Window; References; Chapter 2: Characters ofIschemic Stroke andRecanalization Arteries; 1 Introduction; 2 Characters oftheIschemic Stroke; 2.1 Epidemiology andRisk Factors ofIschemic Stroke; 2.2 The Imaging andDiagnosis ofIschemic Stroke; 2.3 The Pathophysiology ofIschemic Stroke; 2.3.1 Excitotoxicity; 2.3.2 Inflammatory Response; 2.3.3 Apoptosis; 2.3.4 Autophagy. 2.3.5 Pyroptosis3 Artery Recanalization ofIschemic Stroke; 3.1 Intravenous Thrombolytic andAntiplatelet Therapy Treatment; 3.2 Endovascular Treatment forAcute Ischemic Stroke; 3.3 Antioxidant andOther Treatment; 4 Reperfusion Injury After Artery Recanalization; 5 Conclusion; References; Chapter 3: Cerebral Ischemic Reperfusion Injury (CIRI) Cases; 1 Case Description; 2 Discussion; References; Chapter 4: CIRI After Early Recanalization; 1 Hemorrhage Transformation (HT); 1.1 Mechanisms; 1.1.1 Oxidative Stress; 1.1.2 Neurovascular Unit Injury; 1.2 Predictive Imaging Markers. 1.2.1 Brain-Blood Barrier Permeability1.2.2 Postischemic Hyperperfusion; 2 Infarct Growth; 2.1 Mechanisms; 2.1.1 Apoptosis; 2.1.2 Neutrophil Infiltration andImmune Inflammation; 2.2 Predictive Imaging Markers; 2.2.1 No-Reflow Phenomenon; 2.2.2 Cerebral Neutrophil Recruitment; 2.2.3 Vascular Inflammation; 2.2.4 Postischemic Hyperperfusion; 3 Brain Edema; 3.1 Mechanisms andEdema Types; 3.1.1 Brain-Blood Barrier Damage andVasogenic Edema; 3.1.2 Postischemic Hyperperfusion andCytotoxic Edema; 4 Treatments; 4.1 Ischemic Conditioning Therapy; 4.1.1 Ischemic Preconditioning Therapy. 4.1.2 Ischemic Postconditioning Therapy4.2 Immunosuppressive Agents; 4.3 Hypothermia Treatment; 5 Conclusion; References; Chapter 5: Programmed Cell Death inCIRI; 1 Introduction; 2 Apoptotic Cell Death inCIRI; 2.1 Molecular Biology Mechanism ofApoptosis AfterIschemic Stroke; 2.1.1 Molecules Related toApoptosis ofNeurons; Caspase Family; B-Cell Leukemia/Lymphoma 2 (Bcl-2) Family; Tumor Necrosis Factor Receptor (TNFR) Superfamily; Other Molecules; 2.2 Pathways Related toApoptosis ofCIRI; 2.2.1 Intrinsic Pathway; 2.2.2 Extrinsic Pathway; 2.3 Significance ofApoptosis inCIRI.
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2018
• Extent: 1 online resource (xvii, 259 pages), illustrations (some color)
• Subjects: 616.8/1; Cerebral ischemia; Reperfusion injury; HEALTH & FITNESS -- Diseases -- General; MEDICAL -- Clinical Medicine; MEDICAL -- Diseases; MEDICAL -- Evidence-Based Medicine; MEDICAL -- Internal Medicine; Cerebral ischemia; Reperfusion injury; Electronic books
• Languages: English
• ISBNs: 9783319901947
• Related ISBNs: 331990194X; 9783319901930; 3319901931
• Notes: Note: Online resource; title from PDF title page (SpringerLink, viewed July 10, 2018).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.