5-HT2A receptors in the central nervous system. (2018)
- Record Type:
- Book
- Title:
- 5-HT2A receptors in the central nervous system. (2018)
- Main Title:
- 5-HT2A receptors in the central nervous system
- Further Information:
- Note: Bruno P. Guiard, Giuseppe Di Giovanni, editors.
- Editors:
- Guiard, Bruno P
Di Giovanni, Giuseppe - Contents:
- Intro; Preface; Contents; Contributors; Part I: Properties and Distribution of the 5-HT2AR; Pharmacological Analysis in Favour of a Physiological Role for the Constitutive Activity of 5-HT2A Receptors in Learning; Introduction; Physiology and Pathophysiology of 5-HT2A Receptors; Constitutive Activity of 5-HT2A Receptors: Pharmacology and In Vitro Consideration; Constitutive Activity and the Inverse Agonists; Constitutive Activity of 5-HT2A Receptors In Vitro; Constitutive Activity of 5-HT2A Receptors In Vivo; The Conditioned Eye Blink Response and the 5-HT2A Receptors. Role of Endogenous 5-HT in the Conditioned Eye Blink ResponseDirect Pharmacological Evidence for the Constitutive Activity of 5-HT2A Receptor in the Conditioned Eyeblink Response; The Pharmacological Limits: An Open Discussion; MDL11, 939 Under the Spotlight; Constitutive Activity of 5-HT2A Receptors in Other Models of Learning; The Conditioned Avoidance Response; The Autoshaping Learning Task; The Physiological Meaning of the Constitutive Activity of 5-HT2A Receptors; Conclusion; References. βArrestins: Ligand-Directed Regulators of 5-HT2A Receptor Trafficking and Signaling EventsClassical Regulation of GPCRs by βarrestins; Functional Selectivity and βarrestin Bias; βarrestin2-Mediated Regulation of the 5-HT2A Receptor; βArrestin2 Interactions with the 5-HT2A Receptor; Desensitization of the 5-HT2A Receptor; Internalization of the 5-HT2A Receptor; βArrestinsIntro; Preface; Contents; Contributors; Part I: Properties and Distribution of the 5-HT2AR; Pharmacological Analysis in Favour of a Physiological Role for the Constitutive Activity of 5-HT2A Receptors in Learning; Introduction; Physiology and Pathophysiology of 5-HT2A Receptors; Constitutive Activity of 5-HT2A Receptors: Pharmacology and In Vitro Consideration; Constitutive Activity and the Inverse Agonists; Constitutive Activity of 5-HT2A Receptors In Vitro; Constitutive Activity of 5-HT2A Receptors In Vivo; The Conditioned Eye Blink Response and the 5-HT2A Receptors. Role of Endogenous 5-HT in the Conditioned Eye Blink ResponseDirect Pharmacological Evidence for the Constitutive Activity of 5-HT2A Receptor in the Conditioned Eyeblink Response; The Pharmacological Limits: An Open Discussion; MDL11, 939 Under the Spotlight; Constitutive Activity of 5-HT2A Receptors in Other Models of Learning; The Conditioned Avoidance Response; The Autoshaping Learning Task; The Physiological Meaning of the Constitutive Activity of 5-HT2A Receptors; Conclusion; References. βArrestins: Ligand-Directed Regulators of 5-HT2A Receptor Trafficking and Signaling EventsClassical Regulation of GPCRs by βarrestins; Functional Selectivity and βarrestin Bias; βarrestin2-Mediated Regulation of the 5-HT2A Receptor; βArrestin2 Interactions with the 5-HT2A Receptor; Desensitization of the 5-HT2A Receptor; Internalization of the 5-HT2A Receptor; βArrestins as Facilitators of 5-HT2A Receptor Signaling; βarrestin2 and the Head Twitch Response; βarrestin2 and Atypical Antipsychotics; Conclusions; References; 5-HT2A Receptor Heterodimerization. Pharmacological Aspects of 5-HT2A Receptor HeteromerizationStructural Aspects of 5-HT2A Receptor Heteromerization; Methodology Used in GPCRs Heterodimerization; References; Brain Distribution; Introduction; Thelencephalon; Neocortex; Olfactory System; Septum; Hippocampal Region; Hippocampal Formation; Parahippocampal Region; Amygdaloid Complex; Deep Pallial Components; Cortical Pallial Components; Subpallial Components; Basal Ganglia; Diencephalon; Epithalamus; Thalamus; Hypothalamus; Brainstem; Mesencephalon; Pons; Medulla Oblongata; Cerebellum; References. PET Imaging of the 5-HT2A Receptor System: A Tool to Study the Receptorâ#x80;#x99;s In Vivo Brain FunctionInvolvement of the 5-HT2A Receptor in the Neuronal Signal Cascade and Its Role in Pathological Conditions; Positron Emission Tomography (PET); PET; Theoretical Background; Basic Physical Principle; Methodology and PET Quantifications; Methodology; Tracer Dose Concept; PET Kinetic Analysis and the Binding Potential; Tracer Kinetics; In Vivo Selectivity and Occupancy Measurements; Success Criteria for a 5-HT2A Receptor Ligand; Receptor Availability for 5-HT2A PET Imaging. … (more)
- Publisher Details:
- Cham, Switzerland : Humana Press
- Publication Date:
- 2018
- Extent:
- 1 online resource
- Subjects:
- 612.8/042
Serotonin -- Receptors
Central nervous system
MEDICAL -- Physiology
SCIENCE -- Life Sciences -- Human Anatomy & Physiology
Central nervous system
Serotonin -- Receptors
Electronic books - Languages:
- English
- ISBNs:
- 9783319704746
3319704745 - Related ISBNs:
- 9783319704722
- Notes:
- Note: Online resource; title from PDF title page (SpringerLink, viewed Februrary 20, 2018).
- Access Rights:
- Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
- Access Usage:
- Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.
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- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library HMNTS - ELD.DS.396827
- Ingest File:
- 02_422.xml