Leucine-Rich Repeat kinase 2 (LRRK2). ([2017])

• Record Type: Book
• Further Information: Note: Hardy J. Rideout, editor.
• Editors: Rideout, Hardy J
• Contents: Part I: Clinical and Genetic Considerations of LRRK2 Associated Parkinson's Disease -- Leucine-rich repeat kinase (LRRK2) genetics and Parkinson's disease -- Clinical features of LRRK2 carriers with Parkinson's disease -- Part II: Fundamentals of LRRK2 Biology -- LRRK2 phosphorylation -- Understanding the GTPase activity of LRRK2: regulation, function and neurotoxicity -- LRRK2 and autophagy -- Molecular insights and functional implication of LRRK2 dimerization -- LRRK2 and the immune system -- Regulation of LRRK2 by phosphatases -- Part III: LRRK2 Neurodegeneration, Modeling, and Therapeutic Options -- Animal models of LRRK2-associated Parkinson's disease -- LRRK2 and the?LRRKtosome? at the crossroads of programmed cell death: Clues from RIP kinase relatives -- Interaction of LRRK2 and?-synuclein in Parkinson's disease -- Mechanisms of mutant LRRK2 neurodegeneration -- Small molecule inhibitors of LRRK2.
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2017
• Extent: 1 online resource
• Subjects: 612.8; Neurogenetics; Chromosomes; Parkinson's disease -- Genetic aspects; MEDICAL -- Physiology; SCIENCE -- Life Sciences -- Human Anatomy & Physiology; Chromosomes; Neurogenetics; Biomedicine; Neurosciences; Neurology; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Electronic books
• Languages: English
• ISBNs: 9783319499697; 3319499696
• Related ISBNs: 9783319499673; 331949967X
• Notes: Note: Includes bibliographical references.; Note: Online resource; title from PDF title page (EBSCO, viewed April 05, 2017).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.