Neuroprotective therapy for stroke and ischemic disease. (2017)

• Record Type: Book
• Further Information: Note: Paul A. Lapchak, John H. Zhang, editors.
• Editors: Lapchak, Paul A; Zhang, J. H (John H.)
• Contents: Preface; Contents; Contributors; Part I: Stroke Neuroprotection: The History and Learning Experience; Chapter 1: Reflections on€Neuroprotection Research and€the€Path Toward Clinical Success; 1 Introduction: A€Brief Chronological History of€Stroke; 1.1 Of Neurons and€Time; 1.1.1 Extrapolated Stroke and€Cerebrovascular Disease Incidence; 1.1.2 Time-brain matters!; 2 Limited Benefit Treatment Options for€Acute Ischemic Stroke Victims: Successes!; 2.1 Thrombolysis: Thrombolytic Therapy; 2.2 Endovascular Procedures and€Thrombolysis; 2.2.1 ESCAPE [32]: Table 1.3; 2.2.2 EXTEND-IA [33]: Table 1.4. 2.2.3 MR CLEAN [31]: Table 1.52.2.4 REVASCAT [34]: Table 1.6; 2.2.5 SWIFT-PRIME [35]: Table 1.7; 2.2.6 Endovascular Procedure Benefit; 2.3 Embolectomy Concerns; 2.3.1 Patient Population Selection for€Embolectomy and€Thrombolysis; 2.3.2 Limitations of€the€Trials; Patient Selection Bias; Saving Penumbra; Time to€Treatment; Coadministration of€Thrombolytics; 2.3.3 Future of€Embolectomy; Endovascular Procedure Summary; 3 Neuroprotection; 3.1 Evolving Opportunities; 3.2 The RIGORs of€Drug Development: Guideline Adherence; 3.3 Meta-analysis of€Translational Studies; 4 Comorbidities and€Models. 4.1 Hypertension Models4.2 Diabetic Models; 4.2.1 Coadministration of€Drugs in€Stroke Models; 5 Drug Development Considerations; 6 Conclusion; References; Chapter 2: Systematic Review and€Meta-analysis: Important Tools in€Understanding Drug Development for€Stroke; 1 Introduction; 2 Evidence-Based Approaches to€Understanding Translational Stroke Research; 2.1 Assessing the€Quality and€Range of€Available Evidence; 2.1.1 Quality of€Evidence; 2.1.2 Range of€Evidence; 2.2 Assessing for€Publication Bias; 2.3 Impacts of€Systematic Reviews. 2.4 Providing Potential Explanations for€Discrepancies Between€Preclinical and€Clinical Trial Results2.5 Informing Clinical Trial Design; 3 Limitations of€Systematic Review and€Meta-analysis; 4 Future of€Preclinical Systematic Review and€Meta-analysis; 5 Conclusions; 6 Resources; References; Chapter 3: Neuroprotection Is Technology, Not Science; 1 Introduction; 2 Part 1: Physics and€Biology; 2.1 A Tale of€Two Cultures; 2.2 What Is Measured?; 2.3 The Mathematizing of€Biology; 3 Part 2: A€Theory of€Acute Cell Injury; 3.1 Introduction to€the€Theory; 3.2 Qualitative Description of€the€Theory. 3.3 The Autonomous Theory3.4 Solutions of€the€Autonomous Theory; 3.5 Monostable Outcome; 3.6 Bistable Outcome; 3.7 Pre-treatment Therapies; 3.8 Closed Trajectories and€the€Autonomous Theory; 4 Technological Applications; 4.1 Approaches to€Therapy; 4.2 Ascertaining Injury Intensity; 4.3 Protective Therapeutics; 4.4 The Non-autonomous Dynamical Theory of€Acute Cell Injury; 4.5 Sequential Injuries; 4.6 Solutions of€the€Multiple Injury Model; 4.6.1 Preconditioning; 4.6.2 Post-injury Drug Treatment; 4.7 Spatial Applications; 4.8 A Possible Neuroprotective Technology.
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2017
• Extent: 1 online resource
• Subjects: 616.8/1; 610; Cerebrovascular disease -- Prevention; Ischemia; Neuroprotective agents; HEALTH & FITNESS -- Diseases -- General; MEDICAL -- Clinical Medicine; MEDICAL -- Diseases; MEDICAL -- Evidence-Based Medicine; MEDICAL -- Internal Medicine; Cerebrovascular disease -- Prevention; Ischemia; Neuroprotective agents; Biomedicine; Neurosciences; Cardiology; Brain Ischemia -- therapy; Fulltext; Internet Resources
• Languages: English
• ISBNs: 9783319453453; 3319453459
• Related ISBNs: 9783319453446; 3319453440
• Notes: Note: Includes bibliographical references at the end of each chapters and index.; Note: Online resource; title from PDF title page (SpringerLink, viewed January 24, 2017).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.