Handbook of sepsis. (2018)

• Record Type: Book
• Further Information: Note: Edited by W. Joost Wiersinga, Christopher W. Seymour.
• Editors: Wiersinga, W. Joost; Seymour, Christopher Warren
• Contents: Intro; Preface; Contents; Part I: Sepsis: An Overview; 1: What Is Sepsis?; 1.1 Introduction; 1.2 The Origins of Sepsis; 1.3 Sepsis Was About Inflammation and Not the Pathogen; 1.4 Sepsis Is Now About Organ Dysfunction and Not Inflammation; 1.5 Multiple Organ Dysfunction; 1.6 Clinical Recognition of Sepsis; 1.7 Risk Factors and Disease Course; 1.8 Finding a Cure for Sepsis; 1.9 Clinical and Public Misunderstandings; 1.10 Challenges and the Way Forward; References; 2: The Epidemiology of Sepsis; 2.1 Introduction; 2.2 Incidence and Acute Mortality. 2.2.1 Sepsis Incidence and Outcomes by Age2.2.2 Changes in Incidence and Outcomes Over Time; 2.2.3 Sepsis Incidence by Chronic Medical Conditions; 2.2.4 Maternal Sepsis; 2.2.5 Sepsis Incidence by Demographics and Socioeconomic Status; 2.3 Etiology and Characteristics of Sepsis; 2.3.1 Context; 2.3.2 Site of Infection; 2.3.3 Pathogen; 2.3.4 Acute Organ Dysfunction and Failure; 2.4 Long-Term Outcomes; 2.4.1 Late Mortality; 2.4.2 Physical, Cognitive, and Mental Health Impairment; 2.4.3 Healthcare Utilization and Hospital Readmission; 2.4.4 Recurrent Sepsis. 2.4.5 Cardiovascular EventsReferences; Part II: The Pathogenesis of Sepsis; 3: Pathogenesis of Sepsis; 3.1 Introduction; 3.2 Pathogens and Infection Sites; 3.3 Host Recognition of Pathogens; 3.4 Hyperinflammation; 3.4.1 Complement System; 3.4.2 Coagulation System and Vascular Endothelium; 3.4.3 Neutrophil Extracellular Traps; 3.5 Immune Suppression; 3.5.1 Apoptosis of Immune Cells; 3.5.2 Reprogramming of Monocytes and Macrophages; 3.5.3 Cellular Metabolism; 3.6 Microbiome; References; 4: The Coagulation System in Sepsis; 4.1 Sepsis and Coagulation. 4.2 Frequency of Clinically Relevant Coagulopathy in Sepsis4.3 Pathways Leading to Coagulation Abnormalities in Sepsis; 4.4 Inflammation and the Coagulopathy of Sepsis; 4.5 Diagnosis of the Coagulopathy in Sepsis; 4.6 Supportive Treatment of Coagulation Abnormalities in Sepsis; 4.7 New Pathways and Targets in the Management of DIC; References; 5: The Endocrine System in Sepsis; 5.1 The Endocrine System; 5.1.1 Introduction; 5.1.2 Hormone Secretion Control Mechanisms; 5.1.3 Organization of the Endocrine System; 5.1.3.1 The Adrenergic System; 5.1.3.2 The Pituitary Hypothalamic Axis. 5.1.3.3 The Adrenal Glands5.1.3.4 Vasopressin; 5.1.3.5 Insulin; 5.1.3.6 The Thyroid Gland; 5.1.3.7 The Somatotropic Axis; 5.1.3.8 Sex Hormones; 5.2 The Endocrine Response to Stress; 5.3 Endocrine Alterations During Sepsis; 5.3.1 The Adrenergic System; 5.3.2 The Hypothalamic-Pituitary-Adrenal Axis; 5.3.2.1 Corticosteroids in Septic Shock; 5.3.3 Vasopressin; 5.3.4 Insulin; 5.3.5 Thyroid Hormones; 5.3.6 Growth Hormone; 5.3.7 Androgens; References; 6: Sepsis Biomarkers; 6.1 Introduction; 6.2 Biomarkers; 6.2.1 C-Reactive Protein; 6.2.2 Procalcitonin; 6.2.3 CD64.
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2018
• Extent: 1 online resource (viii, 267 pages), illustrations (some color)
• Subjects: 616.9/44; Septicemia -- Handbooks, manuals, etc; HEALTH & FITNESS -- Diseases -- General; MEDICAL -- Clinical Medicine; MEDICAL -- Diseases; MEDICAL -- Evidence-Based Medicine; MEDICAL -- Internal Medicine; Septicemia; Electronic books; Handbooks and manuals
• Languages: English
• ISBNs: 9783319735061; 3319735063
• Related ISBNs: 9783319735054; 3319735055
• Notes: Note: Online resource; title from PDF title page (SpringerLink, viewed April 18, 2018).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.