Recent advances in retinoblastoma treatment. (2015)

• Record Type: Book
• Further Information: Note: Jasmine H. Francis, David H. Abramson, editors.
• Editors: Francis, Jasmine H; Abramson, David H
• Contents: Preface; Contents; Contributors; 1: Molecular Biology of Retinoblastoma; 1.1 The First Tumor Suppressor; 1.2 Structural Biology of the Rb Pathway; 1.2.1 The RB1 Gene; 1.2.2 The Rb Phosphorotein; 1.3 Functions of the Rb Pathway; 1.3.1 Regulation of E2F-Responsive Gene Transcription; 1.3.2 Epigenetic Effects, Including Active Repression of Other Genes Through Chromatin Remodeling; 1.3.3 Cell Cycle Inhibition; 1.3.4 Maintenance of Cellular Differentiation; 1.3.5 Anti-apoptotic Function; 1.3.6 Maintenance of Chromosomal Stability; 1.4 Disruption of the Rb Pathway. 1.4.1 Modulation of Rb Phosphorylation State1.4.2 Viral Oncoproteins; 1.4.3 Epigenetics and Imprinting; 1.5 Clinical Importance of Retinoblastoma Molecular Genetics; 1.5.1 Heritability; 1.5.2 Second Primary Tumors; 1.5.3 Age of Onset; 1.5.4 Retinocytoma and Low Penetrance Retinoblastoma; 1.5.5 Vitreous Seeding; 1.5.6 Future Treatments; 1.6 Conclusion; References; 2: Challenges of Genetic Susceptibility Testing for Retinoblastoma; 2.1 Introduction; 2.2 Definition of Genetic Counseling; 2.3 Referrals for Genetic Counseling in Retinoblastoma Clinics. 2.4 Elements of Genetic Counseling2.5 Components of Pre-test Genetic Counseling; 2.6 Genetic Testing and Types of RB1 Results; 2.7 Potential Risks of RB1 Testing; 2.8 Explanation of the Potential Benefits and Uses of RB1 Genetic Testing; 2.9 Referral to Prenatal Genetic Counselor and Options for Prenatal Testing; 2.10 Explanation of the Limitations of RB1 Genetic Testing; 2.11 Case Scenarios; 2.12 Other Considerations of RB1 Testing; 2.13 Components of Post-test Genetic Counseling; 2.14 Conclusion; References; 3: Technique of Ophthalmic Artery Chemosurgery for Retinoblastoma. 3.1 Introduction3.2 Material and Methods; 3.2.1 Patient Population; 3.2.2 Protocol; 3.2.3 Intra-arterial Chemotherapy Procedure; 3.3 Results; 3.4 Conclusion; References; 4: Vitreous Disease and the Technique, Safety and Toxicity of Intravitreal Chemotherapy for Retinoblastoma; 4.1 Vitreous Disease; 4.1.1 Dust; 4.1.2 Spheres; 4.1.3 Clouds; 4.2 Technique; 4.2.1 History; 4.2.2 Safety Enhancement; 4.2.3 Decreasing Needle Size and Volume of Drug; 4.2.4 Lowering Intraocular Pressure; 4.2.5 Injection Site Precautions; 4.2.6 Exclusion Criteria; 4.2.7 Irrigation/Water Submersion. 4.2.8 Ocular and Needle Washings4.2.9 Tethered Seeds; 4.3 Ocular Toxicity; 4.3.1 Electroretinogram: Clinical; 4.3.2 Electroretinogram: Preclinical; 4.3.3 Clinical Signs of Toxicity; 4.4 Systemic Toxicity; 4.5 Conclusion; References; 5: Electroretinogram Monitoring of Retinoblastoma Treatment; 5.1 Introduction; 5.2 Ophthalmic Artery Chemotherapy Infusion; 5.3 ERG Protocol; 5.4 ERG Testing Schedule; 5.5 ERG Recording During Examination Under Anesthesia: Technical Considerations; 5.5.1 Baseline Noise; 5.5.2 Effect of Ocular Manipulation on the ERG.
• Publisher Details: Cham : Springer
• Publication Date: 2015
• Extent: 1 online resource, illustrations (some color)
• Subjects: 616.99/484; Retinoblastoma -- Treatment; HEALTH & FITNESS -- Diseases -- Cancer; MEDICAL -- Oncology; MEDICAL -- Pediatrics; Medicine; Oncology; Ophthalmology; Pediatrics; Medicine & Public Health; Ophthalmology; Oncology; Pediatrics; Retinoblastoma -- therapy; Electronic books
• Languages: English
• ISBNs: 9783319194677; 3319194674; 3319194666; 9783319194660
• Related ISBNs: 9783319194660
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (Ebsco, viewed July 28, 2015).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.