Renal cell carcinoma : molecular targets and clinical applications /: molecular targets and clinical applications. ([2015])

• Record Type: Book
• Further Information: Note: Ronald M. Bukowski, Robert A. Figlin, Robert J. Motzer, editors.
• Editors: Bukowski, Ronald M; Figlin, Robert A; Motzer, Robert J
• Other Names: Bukowski, Ronald M
• Contents: 1st Edition Preface; 2nd Edition Preface; Histology; von Hippel-Lindau (VHL) Syndrome; Systemic Therapy: Metastatic Disease; References; Contents; Contributors; Chapter 1: Targeted Therapy for Metastatic Renal Cell Carcinoma: Introduction; Background; Molecular Genetics: RCC; Prognostic Factors in Renal Cell Carcinoma; Management of Patients with Advanced RCC; Bevacizumab; Sorafenib; Sunitinib; Pazopanib; Axitinib; mTOR Inhibitors: Temsirolimus; Everolimus; The Evolving Treatment Landscape for RCC; Comparative Clinical Trials; Combination Approaches; Sequential Therapy RCC; Future Approaches. Renal Cell Carcinoma Pathology According to Molecular PathwayPseudo-hypoxic Pathway; Association with VHL Gene Changes and TSC1/TSC2 Loss; Association with Krebs Cycle Mutations; c-MET Pathway; FLCN Pathway; Undefined Pathway; Other Pathological Renal Cell Carcinomas Entities; Unclassified Renal Cell Carcinoma; Conclusions; References; Chapter 3: Genomic Assessment of Renal Cancer; Introduction; Methods for Genomic Characterization; Cytogenetics and Copy Number Change; DNA Sequence and Somatic Mutations; Epigenetic Analysis; Transcript Analysis; Technique Summary. Cytogenetics and Copy Number Changes in Renal CancerCopy Number Changes in ccRCC; Prognostic Associations with Copy Number Changes in ccRCC; Familial Renal Cancer Due to Chromosome 3 Translocations; Somatic Genetics of Renal Cancer; Mutated Genes in ccRCC; Activation of the PI3K/AKT Signaling Pathway in ccRCC; ccRCC Tumorigenesis and Prognosis in Relation to Genetic Mutation; Epigenetic Regulation in ccRCC; Mutations in Epigenetic Regulatory Genes; PBRM1; BAP1; Histone-Modifying Genes (HMGs); Genomic Assessments of Chromatin; DNA Methylation Phenotypes; Renal Cancer Transcript Assessments.
• Edition: 3rd ed
• Publisher Details: New York : Springer
• Publication Date: 2015
• Copyright Date: 2015
• Extent: 1 online resource (620 pages)
• Subjects: 610 616.07548 616994; Medicine; Nuclear medicine; Oncology; Health & Biological Sciences; Kidneys -- Cancer; Medicine; Nuclear medicine; Oncology; Renal cell carcinoma; Urologic Neoplasms; Adenocarcinoma; Urogenital Neoplasms; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Site; Neoplasms; Neoplasms by Histologic Type; Disease; Kidney Neoplasms; Carcinoma, Renal Cell; Kidneys -- Cancer; Medicine; Nuclear medicine; Oncology; Renal cell carcinoma; Electronic books
• Languages: English
• ISBNs: 9781493916221
• Related ISBNs: 149391622X
• Notes: Note: Includes bibliographical references and index.; Note: Print version record.; Note: Online resource; title from PDF title page (ebrary, viewed April 2, 2015).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.