Nucleic acid sensing and immunity. Part A (2019)

• Record Type: Book
• Further Information: Note: Edited by Claire Vanpouille-Box, Lorenzo Galluzzi.
• Editors: Vanpouille-Box, Claire; Galluzzi, Lorenzo
• Contents: Front Cover; Nucleic Acid Sensing and Immunity, Part A; Copyright; Contents; Contributors; Nucleic Acid Sensing at the Interface Between Innate and Adaptive Immunity; Acknowledgments; Disclosures; References; Chapter One: Discrimination Between Self and Non-Self-Nucleic Acids by the Innate Immune System; 1. Introduction; 2. Intracellular Nucleic Acid Sensors; 2.1. RLRs; 2.2. ALRs; 2.3. cGAS; 2.4. ISGs; 3. Extracellular Nucleic Acid Recognition; 3.1. TLRs; 3.2. TLR9; 3.3. TLR3; 3.4. TLR7 and TLR8; 4. Modifications Enabling DNA Discrimination; 4.1. APOBEC3; 4.2. SAMHD1 5. Modifications Allowing RNA Discrimination5.1. 2-O-Methyltransferase; 5.2. ADAR; 6. Endogenous Nucleic Acids as DAMPs; 6.1. Stress-Induced Release of Nucleotides; 6.2. The Role of Nucleotide Binding Proteins in Inflammation; 7. Endogenous Nucleotides Facilitate Inflammation; 7.1. Self-DNA Accumulation and Inflammation; 7.2. Self-RNA Accumulation and Inflammation; 8. Conclusion; Acknowledgment; References; Chapter Two: Intracellular RNA Sensing in Mammalian Cells: Role in Stress Response and Cancer Therapies; 1. Introduction; 2. Overview of RNA Sensing Systems in Mammalian Cells 2.1. Toll-Like Receptors (TLRs)2.2. RIG-I-Like Receptors (RLRs); 2.3. NOD-Like Receptors (NLRs); 2.4. RNA-Dependent Protein Kinase (PKR); 2.5. OAS-Like Receptors (OLRs); 3. Discrimination of Self From Non-Self RNA. RNA Stress as an Aberrant Recognition of Self-RNAs; 4. Endogenous Ligands of RNA Sensors as Stress-Induced DAMPs; 4.1. SINEs/Alu1 Elements; 4.2. Long Interspersed Elements (LINEs); 4.3. Long Terminal Repeats/Endogenous Retroviruses (LTR/ERVs); 4.4. Small Non-Coding RNAs (snRNAs and snoRNAs); 5. Epigenetic Silencing and Chromatin Conformation in Regulation of RNA DAMPs 6. Intercellular and Intracellular Redistribution of RNA DAMPs7. Stress Granules, P-Bodies, and PML Nuclear Bodies as Cellular Compartments of RNA Stress Response and IFN Signaling; 8. Relationships Between RNA-Dependent and DNA-Dependent Pathways in Tumor and Host Immune Cells; 9. Role of RNA Sensors in Conventional Therapy and Immunotherapy of Cancer; 9.1. Action of IFNs on Tumor Cells and Role of RLRs in Conventional Cancer Therapy; 9.2. Action of IFNs on Immune Cells and Role of RNA Sensors in Cancer Immunotherapy 9.3. Dualism of IFN Signaling and Potential Strategies to Activate Cytotoxic Functions in Tumor Cells10. Concluding Remarks and Future Directions; Acknowledgments; References; Chapter Three: Negative Regulation of Cytosolic Sensing of DNA; 1. Introduction; 2. Candidate Sensors of Intracellular DNA; 3. DNA Sensing via the cGAS/STING Pathway; 4. Regulation of cGAS/STING Dependent Signaling; 5. Auto-Inflammatory Responses Mediated by cGAS/STING; 6. Viral Strategies to Modulate cGAS/STING Function; 7. Modulation of Innate Immune Response by NLRs
• Publisher Details: Cambridge, MA, United States : Academic Press
• Publication Date: 2019
• Extent: 1 online resource
• Subjects: 572.8; 574.87328; Nucleic acids; Nucleic acids -- Regulation; RNA; SCIENCE / Life Sciences / Biology; Electronic books; Electronic books
• Languages: English
• ISBNs: 9780128159804; 0128159804
• Related ISBNs: 9780128159798; 0128159790
• Notes: Note: Includes bibliographical references.; Note: Online resource; title from PDF title page (EBSCO, viewed February 26, 2019).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.