Genomic mosaicism in neurons and other cell types. ([2017])

• Record Type: Book
• Further Information: Note: Editors, José María Frade, Fred H. Gage.
• Editors: Frade, José María; Gage, F (Fred), 1950-
• Contents: Introduction. Principles and approaches for discovery and validation of somatic mosaicism in the human brain / Alexej Abyzov, Alexander E. Urban, Flora M. Vaccarino -- Aneuploidy and ploidy variation. FISH-based assays for detecting genomic (chromosomal) mosaicism in human brain cells / Yuri B. Yurov, Svetlana G. Vorsanova, Ilia V. Soloviev, Alexei M. Ratnikov [and others] -- Flow cytometric and sorting analyses for nuclear DNA content, nucleotide sequencing, and interphase FISH / Gwendolyn E. Kaeser, Jerold Chun -- Flow cytometric quantification, isolation, and subsequent epigenetic analysis of tetraploid neurons / Noelia López-Sánchez, Iris Patiño-Parrado, José Mar̕a Frade -- A cytomic approach towards genomic individuality of neurons / Thomas Arendt, Birgit Belter, Martina K. Brückner, Uwe Ueberham, Markus Morawski [and others] / DNA copy number variation. Single-cell CNV detection in human neuronal nuclei / Margaret B. Wierman, Ian E. Burbulis, William D. Chronister, Stefan Bekiranov [and others] -- Multiple annealing and looping-based amplification cycles (MALBAC) for the analysis of DNA copy number variation / Chenghang Zong -- Competitive PCR for copy number assessment by restricting dNTPs / Luming Zhou, Robert A. Palais, Yotam Ardon, Carl T. Wittwer -- Using cloning to amplify neuronal genomes for whole-genome sequencing and comprehensive mutation detection and validation / Jennifer L. Hazen, Michael A. Duran, Ryan P. Smith, Alberto R. Rodriguez [and others] / LINE-1 retrotransposition. Analysis of LINE-1 retrotransposition in neural progenitor cells and neurons / Angela Macia, Alysson R. Muotri -- Estimation of LINE-1 copy number in the brain tissue and isolated neuronal nuclei / Miki Bundo, Tadafumi Kato, Kazuya Iwamoto -- Analysis of somatic LINE-1 insertions in neurons / Francisco J. Sanchez-Luque, Sandra R. Richardson, Geoffrey J. Faulkner -- Single-cell whole genome amplification and sequencing to study neuronal mosaicism and diversity / Patrick J. Reed, Meiyan Wang, Jennifer A. Erwin, Apuã C.M. Paquola, Fred H. Gage / Genetic and genomic mosaicism in aging and disease. FISH analysis of aging-associated aneuploidy in neurons and nonneuronal brain cells / Grasiella A. Andriani, Cristina Montagna -- Genomic analysis and in vivo functional validation of brain somatic mutations leading to focal cortical malformations / Jae Seok Lim, Jeong Ho Lee -- Using fluorescence in situ hybridization (FISH) analysis to measure chromosome instability and mosaic aneuploidy in neurodegenerative diseases / Julbert Caneus, Antoneta Granic, Heidi J. Chial, Huntington Potter -- Identification of low allele frequency mosaic mutations in Alzheimer disease / Carlo Sala Frigerio, Mark Fiers, Thierry Voet, Bart De Strooper.
• Publisher Details: New York, NY : Humana Press imprint is published by Springer Nature
• Publication Date: 2017
• Copyright Date: 2017
• Extent: 1 online resource (xvi, 382 pages), illustrations (some color)
• Subjects: 576.5; Genomics -- Laboratory manuals; Neurons -- Laboratory manuals; Genomics; Neurons; Mosaicism; Neurons -- physiology; Polymorphism, Single Nucleotide; Genomics -- methods; Electronic books; Laboratory manuals
• Languages: English
• ISBNs: 9781493972807; 1493972804
• Related ISBNs: 9781493972791; 1493972790
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from electronic title page (SpringerLink, viewed September 15, 2017).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.