Computational Epigenetics and Diseases. ([2019])

• Record Type: Book
• Further Information: Note: Loo Keat Wei, editor.
• Editors: Wei, Loo Keat
• Contents: Front Cover; Computational Epigenetics and Diseases; Translational Epigenetics Series; Computational Epigenetics and Diseases; Copyright; Contents; Contributors; 1 -- COMPUTATIONAL EPIGENETICS AND DISEASE; INTRODUCTION; COMPUTATIONAL APPROACHES IN DNA METHYLATION; COMPUTATIONAL APPROACHES IN HISTONE MODIFICATIONS; COMPUTATIONAL APPROACHES IN MIRNAS; COMPUTATIONAL EPIGENETICS IN METABOLIC AND CARDIAC DISORDERS; COMPUTATIONAL EPIGENETICS IN NEUROLOGICAL DISORDERS; COMPUTATIONAL EPIGENETICS AND CANCER; CONCLUSIONS; ACKNOWLEDGMENT; REFERENCES; 2 -- COMPUTATIONAL METHODS FOR EPIGENOMIC ANALYSIS INTRODUCTIONUNBIASED DETECTION OF CHIP-ENRICHMENT; SEGMENTATION OF THE EPIGENOME INTO CHROMATIN STATES; THE DIFFERENTIAL EPIGENOME; REFERENCES; 3 -- STATISTICAL APPROACHES FOR EPIGENETIC DATA ANALYSIS; INTRODUCTION; STATISTICAL MODELING; STATISTICAL METHODOLOGY; FORMULATION OF MULTIPLE TEST PROBLEMS; TEST STATISTICS AND THEIR LIMITING NULL DISTRIBUTIONS; MULTIPLE TEST PROCEDURES: CLOSURE PRINCIPLE; FINITE SAMPLE MODIFICATION: STUDENTIZED PERMUTATION APPROACH; REAL DATA ANALYSIS; DISCUSSION; ACKNOWLEDGMENTS; REFERENCES 4 -- BIOINFORMATICS METHODOLOGY DEVELOPMENT FOR THE WHOLE GENOME BISULFITE SEQUENCINGINTRODUCTION; RESULTS; BETA-BINOMIAL HIERARCHICAL MODEL FOR BOTH SAMPLING AND BIOLOGICAL VARIATIONS; CREDIBLE METHYLATION DIFFERENCE (CDIF) IS A SINGLE METRIC FOR BOTH STATISTICAL AND BIOLOGICAL SIGNIFICANCE OF DIFFERENTIAL ...; FUNCTIONS AND PERFORMANCE OF THE MOABS PIPELINE; SIMULATED BS-SEQ DATA REVEAL THE SUPERIOR PERFORMANCE OF MOABS; MOABS IMPROVES THE DETECTION OF ALLELE-SPECIFIC DNA METHYLATION; MOABS RELIABLY REVEALS DIFFERENTIAL METHYLATION UNDERLYING TFBSS MOABS DETECTS DIFFERENTIAL 5HMC IN ES CELLS USING RRBS AND OXBS-SEQDISCUSSION; METHODS; DISTRIBUTION FOR DIFFERENCE OF TWO BINOMIAL PROPORTIONS; DISTRIBUTION FOR DIFFERENCE OF DIFFERENCE; DISTRIBUTION FOR MEASUREMENTS WITH REPLICATES; ACKNOWLEDGMENTS; REFERENCES; SUPPLEMENTARY METHODS; METHYLATION RATIO OF ONE LOCUS FOLLOWS A BETA DISTRIBUTION; CI FOR SINGLE BINOMIAL PROPORTION; CI FOR DIFFERENCE OF TWO BINOMIAL PROPORTIONS IN DETAIL; IDENTIFICATION OF DMCS FOR TWO OR MORE SAMPLES; IDENTIFICATION OF DMRS FOR TWO SAMPLES BY SIMPLY GROUPING DMCS IDENTIFICATION OF DMRS FOR TWO SAMPLES BY HIDDEN MARKOV MODELIDENTIFICATION HYPOMETHYLATED REGIONS FROM ONE SAMPLE; SUPPLEMENTARY REFERENCES; 5 -- DATA ANALYSIS OF CHIP-SEQ EXPERIMENTS: COMMON PRACTICE AND RECENT DEVELOPMENTS; THE DESIGN OF CHIP-SEQ; THE QUALITY OF CHIP-SEQ DATA; MAPPING CHIP-SEQ READS; PEAK CALLING; DIFFERENTIAL ENRICHMENT DETECTION; ALL-IN-ONE DATA ANALYSIS PIPELINES FOR CHIP-SEQ; BEYOND THE STANDARD PIPELINE: ALLELIC-IMBALANCE DETECTION FROM CHIP-SEQ; SUMMARY; REFERENCES; 6 -- COMPUTATIONAL TOOLS FOR MICRORNA TARGET PREDICTION; INTRODUCTION
• Publisher Details: London : Academic Press
• Publication Date: 2019
• Extent: 1 online resource
• Subjects: 572.8/65; Epigenetics; SCIENCE / Life Sciences / Biochemistry; Electronic books; Electronic books
• Languages: English
• ISBNs: 9780128145142; 0128145145
• Related ISBNs: 9780128145135; 0128145137
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (EBSCO, viewed February 13, 2019).; Note: Vendor-supplied metadata.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
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