Retinal degenerative diseases : mechanisms and experimental therapy /: mechanisms and experimental therapy. ([2018])

• Record Type: Book
• Further Information: Note: Edited by John D. Ash, Robert E. Anderson, Matthew M. LaVail, Catherine Bowes Rickman, Joe G. Hollyfield, Christian Grimm.
• Editors: Ash, John D; Anderson, Robert E (Robert Eugene); LaVail, Matthew M; Rickman, Catherine Bowes; Hollyfield, Joe G; Grimm, Christian, 1962-
• Other Names: International Symposium on Retinal Degenerations, 17th
• Contents: Age-related macular degeneration (AMD). Oxidative stress regulation and DJ-1 function in the retinal pigment epithelium: implications for AMD -- Mitochondria: potential targets for protection in age-related macular degeneration -- Toll-like receptors and age-related macular degeneration -- Alterations in extracellular matrix/Bruch's membrane can cause the activation of the alternative complement pathway via tick-over -- MicroRNA as therapeutics for age-related macular degeneration -- Anaphylatoxin signaling in retinal pigment and choroidal endothelial cells: characteristics and relevance to age-related macular degeneration -- Estimations of retinal blue-light irradiance values and melatonin suppression indices through clear and yellow-tinted intraocular lenses -- Co-expression of wild-type and mutant S163R C1QTNF5 in retinal pigment epithelium -- Gene therapies. Mini-review: cell type-specific optogenetic vision restoration approaches -- Mutation-independent gene therapies for rod-cone dystrophies -- Antisense oligonucleotide-based splice correction of a deep-intronic mutation in CHM underlying choroideremia -- Gene therapy approaches to treat the neurodegeneration and visual failure in neuronal ceroid lipofuscinoses -- Success of gene therapy in late-stage treatment -- Optimizing non-viral gene therapy vectors for delivery to photoreceptors and retinal pigment epithelial cells -- Nanoparticles as delivery vehicles for the treatment of retinal degenerative diseases -- Overexpression of type 3 iodothyronine deiodinase reduces cone death in the Leber congenital amaurosis model mice -- In-vivo diagnostics for structure and function. In vivo functional imaging of retinal neurons using red and green fluorescent calcium indicators -- Optimizing ERG measures of scotopic and photopic critical flicker frequency -- Repeatability and reproducibility of in vivo cone density measurements in the adult zebrafish retina -- Normative retinal thicknesses in common animal models of eye disease using spectral domain optical coherence tomography -- A novel approach for integrating AF-SLO and SDOCT imaging data demonstrates the ability to identify early retinal abnormalities in mutant mice and evaluate the effects of genetic and pharmacological manipulation -- Inflammation and angiogenesis. The role of hypoxia, hypoxia-inducible factor (HIF), and VEGF in retinal angiomatous proliferation -- Neuroinflammation in retinitis pigmentosa, diabetic retinopathy, and age-related macular degeneration: a minireview -- Autoimmune retinopathy: an immunologic cellular-driven disorder -- Inflammation-induced photoreceptor cell death -- Sall1 regulates microglial morphology cell autonomously in the developing retina -- Inherited retinal degenerations. Whole-exome sequencing identifies novel variants that co-segregates with autosomal recessive retinal degeneration in a Pakistani pedigree -- Identification of novel deletions as the underlying cause of retinal degeneration in two pedigrees -- Molecular findings in families with an initial diagnose of autosomal dominant retinitis pigmentosa (adRP) -- Pleiotropic effects of risk factors in age-related macular degeneration and seemingly unrelated complex diseases -- Mapping of canine models of inherited retinal diseases -- A mini-review: Leber congenital amaurosis: identification of disease-causing variants and personalised therapies. Mechanisms of degeneration. Role of fibulins 2 and 5 in retinal development and maintenance -- Identifying key networks linked to light-independent photoreceptor degeneration in visual arrestin 1 knockout mice -- How excessive cGMP impacts metabolic proteins in retinas at the onset of degeneration -- Protein carbonylation-dependent photoreceptor cell death induced by N-Methyl-N-nitrosourea in mice -- Müller glia reactivity and development of gliosis in response to pathological conditions -- Underdeveloped RPE apical domain underlies lesion formation in canine bestrophinopathies -- Binary function of ARL3-GTP revealed by gene knockouts -- Do cGMP levels drive the speed of photoreceptor degeneration? -- Early endosome morphology in health and disease -- The retinal circadian clock and photoreceptor viability -- The role of c-Jun N-terminal kinase (JNK) in retinal degeneration and vision loss -- The evaluation of BMI1 posttranslational modifications during retinal degeneration to understand BMI1 action on photoreceptor death execution -- Primary rod and cone degeneration is prevented by HDAC inhibition -- Impact of MCT1 haploinsufficiency on the mouse retina -- The Leber congenital amaurosis-linked protein AIPL1 and its critical role in photoreceptors -- Alternative splicing for activation of coagulation factor XIII-A in the fish retina after optic nerve injury -- Bisretinoid photodegradation is likely not a good thing -- Further characterization of the predominant inner retinal degeneration of aging Cln3[superscript][delta]ex7/8 knock-in mice -- Differential exon expression in a large family of retinal genes is regulated by a single trans locus -- Molecular chaperone ERp29: a potential target for cellular protection in retinal and neurodegenerative diseases -- The role of microbiota in retinal disease -- Neuroprotection. Current pharmacological concepts in the treatment of the retinitis pigmentosa -- Valproic acid inhibits human retinal pigment epithelial (hRPE) cell proliferation via a P38 MAPK signaling mechanism -- Pigment epithelium-derived factor protects retinal pigment epithelial cells against cytotoxicity "in vitro" -- Brain-derived neurotrophic factor as a treatment option for retinal degeneration -- VEGF as a trophic factor for Müller glia in hypoxic retinal diseases -- Müller cell biological processes associated with leukemia inhibitory factor expression -- Retbindin is capable of protecting photoreceptors from flavin-sensitized light-mediated cell death in vitro -- Constitutive activation mutant mTOR promote cone survival in retinitis pigmentosa mice -- Maintaining cone function in rod-cone dystrophies -- PKG-dependent cell death in 661W cone photoreceptor-like cell cultures (experimental study) -- Retinal cell biology. more than meets the eye: current understanding of RPGR function -- Polarized exosome release from the retinal pigmented epithelium -- The impact of adherens and tight junctions on physiological function and pathological changes in the retina -- TRPV4 does not regulate the distal retinal light response -- Role of sirtuins in retinal function under basal conditions -- The retinol-binding protein receptor 2 (Rbpr2) is required for photoreceptor survival and visual function in the zebrafish -- Opposite roles of MerTK ligands Gas6 and protein S during retinal phagocytosis -- Redundant and nonredundant functions of Akt isoforms in the retina -- Photoreceptor outer segment isolation from a single canine retina for RPE phagocytosis assay -- Preservation of photoreceptor nanostructure for electron tomography using transcardiac perfusion followed by high-pressure freezing and freeze-substitution -- Microtubule-associated protein 1 light chain 3 (LC3) Isoforms in RPE and retina -- Stem cells. The iPSc-derived retinal tissue as a tool to study growth factor production in the eye -- Stem cell-based RPE therapy for retinal diseases: engineering 3D tissues amenable for regenerative medicine -- Validation of iPS cell-derived RPE tissue in animal models -- Cell transplantation for retinal degeneration: transition from rodent to nonhuman primate models -- Talaumidin promotes neurite outgrowth of staurosporine-differentiated RGC-5 cells through PI3K/Akt-dependent pathways.
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2018
• Copyright Date: 2018
• Extent: 1 online resource (xlii, 669 pages), illustrations (some color)
• Subjects: 617.7/35; Retinal degeneration -- Congresses; MEDICAL -- Surgery -- General; Medicine; Neurosciences; Ophthalmology; Retinal degeneration; Retinal Degeneration -- therapy; Retinal Degeneration -- genetics; Electronic books
• Languages: English
• ISBNs: 9783319754024; 3319754025
• Related ISBNs: 9783319754017; 3319754017
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.