Stress, trauma and synaptic plasticity. (2018)

• Record Type: Book
• Further Information: Note: Maxwell Bennett, Jim Lagopoulos.
• Authors: Bennett, M. R; Lagopoulos, Jim
• Contents: A more detailed version of the table of contents can be found in the card for attachments. 1. Grey matter changes in the brain following stress and trauma1.1 During maturity1.2 During Childhood1.3 Animal Models 2. Synaptic changes responsible for grey matter changes in the brain of animal models following stress2.1 Changes in the number of neurons, astrocytes and oligodendrocytes following stress2.2 Changes in the length and volume of dendrites following stress2.3 Discussion2.4 The relation between stress-induced decreases in synapses/dendrites and grey matter loss 3. Identification of the core neural network subserving PTSD in animal models and their modulation3.1 Animal models of PTSD3.2 Neural circuitry subserving animal models of PTSD3.3 Transmitters and growth factors mediating modulation of the core synaptic circuit in PTSD animal models3.4 Conclusion 4. Modulation of the core neural network in stress: the role of Brain Derived Neurotrophic Factor & LTP4.1 BDNF gene transcription controlled by glucocorticoid and mineralocorticoid receptors4.2 Evidence that BDNF gene transcription controlled by epigenetic changes4.3 BDNF control of dendritic spines4.4 BDNF/TrkB control of dendritic spines modulated by glucocorticoid and mineralocorticoid receptors4.5 BDNF/TrkB control of dendritic spines modulated by corticotropin releasing factor (hormone)4.6 Cannabinoid (receptor CB1) modulation of BDNF gene transcription and BDNF/TrkB control of dendritic spines4.7 Serotonin transporter (SERT) modulation of BDNF gene transcription and BDNF/TrkB control of dendritic spines4.8 Conclusion 5. Modulation of the core neural network in stress: the role of Endocannabinoids & LTD5.1 The role of endocannabinoids5.2 Functional amygdala networks in acquisition and extinction5.3 Classical LTP and LTD in the functional networks mediating acquisition and5.4 Endocannabinoids in functioning networks in the basolateral amygdala5.5 Functional amygdala networks that mediate extinction: the roles of LTDi and endocannabinoids at extinction neurons in the basolateral amygdala5.6 Conclusion 6. Functioning of the core neural network in fear and extinction6.1 Fear6.2 Extinction6.3 Synaptic plasticity6.4 Modelling the amygdala in fear and extinction6.5 Identifying the site of extinction failure in the amygdala6.6 BDNF function at synapses in the core neural network for extinction6.7 The role of the MeCP2 complex in extinction6.8 Hypotheses concerning mechanisms for extending periods of extinction Appendix 1: F-actin determination of dendritic spine integrity Appendix 2: Regulation of NMDA receptors.
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2018
• Extent: 1 online resource (xxxiii, 231 pages), illustrations (some color)
• Subjects: 612.8/2; Brain -- Effect of stress on; Nervous system -- Effect of stress on; Electronic books
• Languages: English
• ISBNs: 9783319911168; 3319911163
• Related ISBNs: 9783319911151
• Notes: Note: Includes bibliographical references.; Note: Online resource; title from PDF title page (SpringerLink, viewed February 7, 2019).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.