Computational glioscience. ([2019])

• Record Type: Book
• Further Information: Note: Editors, Maurizio De Pittà, Hugues Berry.
• Editors: Pittá, Maurizio de; Berry, Hugues
• Contents: Intro; Preface; Organization and Approach; Acknowledgements; Contents; Contributors; Introduction; 1 A Neuron-Glial Perspective for Computational Neuroscience; 1.1 Introduction; 1.2 Glial Codes; 1.3 Oligodendrocytes and Regulation of Axonal Electric Conduction; 1.4 Glia Morphology and Functional Specialization; 1.5 Ion Homeostasis and Volume Regulation; 1.6 Gliotransmission; 1.7 Resource Management; 1.8 Microglia in Neuronal and Astrocytic Signaling; 1.9 Glia in Higher Brain Functions; 1.10 Conclusions; References; Calcium Dynamics 2 Data-Driven Modelling of the Inositol Trisphosphate Receptor (IP3R) and its Role in Calcium-Induced Calcium Release (CICR)2.1 Introduction; 2.2 Mathematical Models of Calcium Dynamics/CICR; 2.3 Data-Driven Modelling of Single IP3Rs; 2.3.1 Molecular Structure; 2.3.2 Patch-Clamp Recordings; 2.3.3 Calcium Puffs; 2.3.4 Aggregated Continuous-Time Markov Models; 2.3.5 Estimation of Markov Models from Experimental Data; 2.3.6 The Ullah et al. Model; 2.3.7 Siekmann et al. ``Park-Drive'' Model; 2.3.8 Comparison of Type I and Type II IP3R; 2.4 Using Data-Driven IP3R Models in Calcium Dynamics 2.4.1 Modelling Calcium Puffs Using the Park-Drive IP3R Model2.4.2 The Role of Modal Gating of IP3R in Modulating Calcium Signals; 2.5 Conclusions; 2.6 Future Work; References; 3 Intracellular Calcium Dynamics: Biophysical and Simplified Models; 3.1 Introduction; 3.2 Single-Compartment Ca2+ Models; 3.2.1 The De Young-Keizer Model; 3.2.2 Reduction of the De Young-Keizer Model; 3.3 Spatiotemporal Ca2+ Models; 3.3.1 Waves in the De Young-Keizer Model; 3.3.2 Waves in the Fire-Diffuse-Fire Type Model; 3.3.3 Stochastic Ca2+ Waves; 3.4 Conclusions; References; 4 Modeling of Stochastic Ca2+ Signals 4.1 Introduction4.2 Stochastic Simulation of IP3R Gating Dynamics; 4.2.1 Master Equations of the Stochastic Process; 4.2.2 Gillespie Simulation; 4.2.3 Two-State Markovian Method; 4.2.4 Gate-Based Langevin Approach; 4.2.5 Channel-Based Langevin Approach; 4.3 Stochastic Ca2+ Puff Dynamics; 4.3.1 Limitation of Modeling with Homogeneous Ca2+ Concentration Within IP3R Clusters; 4.3.2 Two-Scale Modeling of Ca2+ Concentration Within IP3R Clusters; 4.3.3 Puff Dynamics in a Langevin Model; 4.3.4 Ca2+ Dynamics with Clustered Channels in a 3D Model; 4.3.5 Simulations with Discrete Ca2+ Ions 4.4 Stochastic Intracellular Ca2+ Signals4.5 Outlook of Intercellular Ca2+ Waves with Stochastic IP3R Dynamics; References; 5 G Protein-Coupled Receptor-Mediated Calcium Signaling in Astrocytes; 5.1 Introduction; 5.2 Modeling Intracellular IP3 Dynamics; 5.2.1 Agonist-Mediated IP3 Production; 5.2.2 IP3 Production by Receptors with -Subunits Other Than q-Type; 5.2.3 Endogenous IP3 Production; 5.2.4 IP3 Degradation; 5.3 Encoding of Stimulation by Combined IP3 and Ca2+ dynamics; 5.3.1 The G-ChI Model for IP3/Ca2+ Signaling; 5.3.2 Different Regimes of IP3 Signaling; 5.3.3 Signal Integration
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2019
• Extent: 1 online resource
• Subjects: 616.8; Neuroglia; Neurosciences; HEALTH & FITNESS / Diseases / General; MEDICAL / Clinical Medicine; MEDICAL / Diseases; MEDICAL / Evidence-Based Medicine; MEDICAL / Internal Medicine; Electronic books; Electronic books
• Languages: English
• ISBNs: 9783030008178; 3030008177
• Related ISBNs: 9783030008154
• Notes: Note: Includes bibliographical references.; Note: Online resource; title from PDF title page (EBSCO, viewed January 29, 2019).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.