High density lipoproteins : from biological understanding to clinical exploitation /: from biological understanding to clinical exploitation. ([2015])

• Record Type: Book
• Uniform Title: High density lipoproteins (Eckardstein and Kardasis)
• Further Information: Note: Arnold von Eckardstein, Dimitris Kardassis, editors.
• Editors: Eckardstein, Arnold von; Kardassis, Dimitris
• Contents: Part 1: Physiology of HDL. Structure of HDL: particle subclasses and molecular components HDL biogenesis, remodeling, and catabolism -- Regulation of HDL genes: transcriptional, posttranscriptional, and posttranslational -- Cholesterol efflux and reverse cholesterol transport -- Functionality of HDL: antioxidation and detoxifying effects -- Signal transduction by HDL: agonists, receptors, and signaling cascades -- Part 2: Pathology of HDL. Epidemiology: disease associations and modulators of HDL-related biomarkers -- Beyond the genetics of HDL: why is HDL cholesterol inversely related to cardiovascular disease? -- Mouse models of disturbed HDL metabolism -- Dysfunctional HDL: from structure-function-relationships to biomarkers -- Part 3: Possible indications and target mechanisms of HDL therapy. HDL and atherothrombotic vascular disease -- HDLs, diabetes, and metabolic syndrome -- High-density lipoprotein: structural and functional changes under uremic conditions and the therapeutic consequences -- Impact of systemic inflammation and autoimmune diseases on apoA-I and HDL plasma levels and functions -- HDL in infectious diseases and sepsis -- High-density lipoproteins in stroke -- Therapeutic potential of HDL in cardioprotection and tissue repair -- Part 4: Treatments for dyslipidemias and dysfunction of HDL. HDL and lifestyle interventions -- Effects of established hypolipidemic drugs on HDL concentration, subclass distribution, and function -- Emerging small molecule drugs -- ApoA-I mimetics -- Antisense oligonucleotides, microRNAs, and antibodies.
• Publisher Details: Cham : Springer
• Publication Date: 2015
• Copyright Date: 2015
• Extent: 1 online resource (xiii, 694 pages), illustrations (some color)
• Subjects: 572/.68; High density lipoproteins -- Physiological effect; High density lipoproteins -- Pathophysiology; High density lipoproteins -- Therapeutic use; Lipoproteins, HDL -- physiology; High density lipoproteins -- Pathophysiology; Biochemical engineering; Energy industries & utilities; Management of specific areas; Manufacturing industries; Medicine; Electronic books
• Languages: English
• ISBNs: 9783319096650; 3319096656
• Related ISBNs: 9783319096643; 3319096648
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from resource home page (SpringerLink, viewed April 19, 2016).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.