Recent Advances in Polyphenol Research. (2019)

• Record Type: Book
• Further Information: Note: Heidi Halbwirth, Karl Stich, Véronique Cheynier, Stéphane Quideau.
• Editors: Halbwirth, Heidi; Stich, Karl; Cheynier, Véronique; Quideau, Stéphane
• Contents: Contributors Preface 1 The Lignans: A Family of Biologically Active Polyphenolic Secondary Metabolites ; Anna K.F. Albertson and Jean-Philip Lumb 1.1 Introduction 1.2 Biosynthesis of lignans 1.3 Synthetic approaches to lignans and derivatives 1.3.1 Biomimetic and bio-inspired approaches 1.3.2 Dibenzylbutyrolactones 1.3.3 Arylnaphthalenes and Aryltetralins 1.3.4 2, 5-Diaryltetrahydrofurans 1.3.5 2-Aryl-4-benzyltetrahydrofurans 1.3.6 Furofurans 1.3.7 Dibenzocyclooctadienes 1.4 Conclusion References 2 Anthocyanin accumulation is controlled by layers of repression ; Andrew C Allan, Kathy E. Schwinn and Richard V. Espley 2.1 Introduction 2.2 MYBs and bHLHs directly activate anthocyanin production 2.3 Exciting phenotypes in horticulture are often caused by variations in the expression of key MYBs 2.4 Is there a cost to the plant of over-accumulation of anthocyanins? 2.5 Controlling anthocyanin levels 2.5.1 Fine control of MYB activator expression 2.6 The MYB activator is degraded at night 2.7 MYB activator competes with MYB repressors 2.8 miRNA targeted degradation of MYB transcript 2.9 Turnover of anthocyanin vacuolar content by peroxidases 2.10 Summary References 3 The subtleties of subcellular distribution: pointing the way to underexplored functions for flavonoid enzymes and end products ; Brenda S.J. Winkel 3.1 Multi-enzyme complexes and metabolic networks 3.2 New insights from global surveys of protein interactions 3.3 The flavonoid metabolon 3.3.1 Earliest evidence 3.3.2 Protein interactions in Arabidopsis 3.3.3 Corroboration in other species 3.4 Subcellular distribution of flavonoid enzymes and evidence for alternative metabolons 3.4.1 Cytoplasmic and vacuolar localization 3.4.2 Plastid and mitochondrial localization 3.4.3 Nuclear localization 3.4.3.1 Flavonoids 3.4.3.2 Flavonoid enzymes 3.5 Post-translational modifications – an underexplored area of flavonoid metabolism 3.6 Why do we need to know? 3.7 Future prospects References 4 Transcriptional and metabolite profiling analyses uncover novel genes essential for polyphenol accumulation ; Wilfried Schwab, Ludwig Ring and Chuankui Song 4.1 Introduction 4.2 Transcriptional and metabolite profiling analyses in strawberry fruit 4.2.1 Analysis of soluble phenolics 4.2.2 Transcript analysis 4.3 Characterization of Peroxidase 4.2.3 Expression analysis 4.2.4 Functional analysis 4.4 Competition of the lignin and flavonoid/anthocyanin pathways as demonstrated by the activity of peroxidase 4.5 Candidate genes putatively correlated with phenolics accumulation in strawberry fruit 4.5.1 Selection of candidates 4.5.2 Effects on metabolites 4.6 Acylphloroglucinol biosynthesis in strawberry fruit 4.6.1 Downregulation of CHS/VPS activity 4.4.2 Isotope labeling experiment 4.7 Glucosylation of acylphloroglucinols 4.7.1 Total in vitro synthesis of strawberry APG glucosides 4.7.2 Downregulation of UGT71K3 in strawberry fruit 4.7.3 Promiscuous activity as an anthocyanidin glucosyltransferase 4.8 Conclusion References 5 Dietary (poly)phenols and vascular health ; Christine Morand, Nicolas Barber-Chamoux, Laurent-Emmanuel Monfoulet and Dragan Milenkovic 5.1 Introduction 5.2 Vascular health: a prerequisite to prevent cardiometabolic diseases and cognitive decline 5.2.1 Vascular function and cardiometabolic diseases 5.2.2 Vascular function and cognitive decline 5.3 Diet and vascular health 5.4 (Poly)phenols: a major family of dietary plant bioactive compounds 5.5 Fate of (poly)phenols in the body and biological activities 5.6 Nutritional interest of flavonoids in protecting cardiovascular health 5.7 Limitation of knowledge and strategy for research 5.8 Findings from translational research on citrus flavanones and vascular health 5.9 Conclusion References 6 Cellular specific detection of polyphenolic Compounds by NMR-and MS-based techniques: – Application to the representative polycyclic aromatics of members of the Hypericaceae, the Musaceae and the Haemodoraceae ; Dirk Hölscher 6.1 Introduction 6.2 The plant genus Hypericum 6.3 Phenylphenalenones: plant secondary metabolites of the Haemodoraceae 6.4 Phenalenone-type phytoalexins 6.5 Laser microdissection and cryogenic NMR as a combined tool for cell type-specific metabolite profiling 6.6 Matrix-free UV-laser desorption/ionization (LDI) at the single-cell level: distribution of secondary metabolites of Hypericum species 6.7 LDI-MSI-based detection of phenalenone-type phytoalexins in a banana-nematode-interaction 6.8 LDI-FT-ICR-MSI reveals the occurrence of phenylphenalenones in red paracytic stomata Acknowledgements References 7 Metabolomics strategies for the dereplication of polyphenols and other metabolites in complex natural extracts ; Jean-Luc Wolfender, Pierre-Marie Allard, Miwa Kubo and Emerson Ferreira Queiroz 7.1 Introduction 7.2 Metabolite profiling and metabolomics 7.2.1 Resolution and throughput improvement of metabolite profiling methods 7.3 Metabolite annotation and dereplication 7.4 Targeted isolation of original polyphenols 7.5 Conclusions References 8 Polyphenols from plant roots: an expanding biological frontier ; Ryosuke Munakata, Romain Larbat, Léonor Duriot, Alexandre Olry, Carole Gavira, Benoit Mignard, Alain Hehn and Frédéric Bourgaud 8.1 Introduction 8.2 Polyphenols in the roots vs shoots: not more, not less, but often different 8.2.1 Examples of root specific polyphenols 8.2.1.1 Flavonoids/Isoflavonoids 8.2.1.2 Naphtoquinones 8.2.1.3 Phenylphenalenone 8.2.1.4 Caffeic acid dihydroxyphenethyl glucosides 8.2.2 Phenolics in roots: general evolutionary context, distribution and translocation 8.3 Allelochemical functions of root polyphenols 8.3.1 Plant microbe interactions 8.3.1.1 Rhizobia 8.3.1.2 Arbuscular mycorrhizal fungi 8.3.1.3 Plant growth promoting Rhizobacteria 8.3.1.4 Endophytes 8.3.1.5 Soil.borne plant pathogens 8.3.2 Plant-nematode and plant-insect herbivore interactions 8.3.3 Plant allelopathy 8.4 Physiological functions of root polyphenols in plants 8.4.1 Inhibition of auxin transport 8.4.2 Nutrient uptake in the rhizosphere 8.4.3 Detoxifying agents (i.e., anti-oxidizing agent) 8.5 Biotechnologies to produce root polyphenols 8.5.1 Production of valuable polyphenols in plant cell/tissue culture 8.5.2 Production of valuable root polyphenols in organ culture systems 8.5.2.1 Hairy roots cultivation systems 8.5.2.2 Adventitious root cultures 8.5.3 Production of polyphenols by aeroponic/hydroponic cultivation systems 8.5.4 Metabolic engineering for the production of root polyphenols 8.5.4.1 Bacteria used as a platform of production 8.5.4.2 Production in yeast 8.6 Conclusion References 9 Biosynthesis of polyphenols in recombinant microorganisms: A path to sustainability ; Kanika Sharma, Jian Zha, Sonam Chouhan, Sanjay Guleria and Mattheos A.G. Koffas 9.1 Introduction 9.2 Flavonoids 9.2.1 Biosynthesis of flavonoids and their derivatives 9.2.2 Metabolic engineering of flavonoids and their derivatives 9.3 Stilbenes 9.3.1 Biosy
• Edition: 1st
• Publisher Details: Wiley-Blackwell
• Publication Date: 2019
• Extent: 1 online resource (432 pages)
• Languages: English
• ISBNs: 9781119427919
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.