Paleogenomics : Genome-Scale Analysis of Ancient DNA /: Genome-Scale Analysis of Ancient DNA. ([2019])

• Record Type: Book
• Further Information: Note: Editors, Charlotte Lindqvist and Om P. Rajora.
• Editors: Lindqvist, Charlotte; Rajora, Om P
• Contents: Intro; Preface; Contents; Contributors; Part I: Concepts, Technical Advances and Challenges; Technical Advances and Challenges in Genome-Scale Analysis of Ancient DNA; 1 Introduction; 2 The Nature of Ancient DNA; 2.1 Understanding Postmortem DNA Damage Pattern; 2.2 Exogenous DNA Contamination; 3 Ancient DNA Extraction Methods; 3.1 Ancient DNA Extraction from Animal Remains; 3.2 Ancient DNA Extraction from Plants; 4 Next-Generation Sequencing and Library Preparation; 4.1 Double-Stranded Versus Single-Stranded Library Preparation; 4.2 Targeted Enrichment 5 Bioinformatic Challenges and Solutions5.1 Authentication of aDNA and Estimation of the Contamination Rate; 5.2 Reconstruction of Ancient Genomes; 5.3 Other Analytical Tools; 6 Conclusions and Future Perspectives; References; Paleoproteomics: An Introduction to the Analysis of Ancient Proteins by Soft Ionisation Mass Spectrometry; 1 Introduction; 2 Soft Ionisation Mass Spectrometry and Proteomics; 3 Paleoproteomes; 3.1 Characterisation of the Bone Proteome; 3.1.1 Bone Collagen; 3.1.2 Non-collagenous Proteins (NCPs) in Bone; 3.2 Information Content of Ancient Bone Proteins 3.2.1 Phylogenetic Information Recovery3.2.2 Species Identification; 3.3 Sequence Limitations; 3.4 Age-Related Information from Proteins and their Post-translational Modifications (PTMs); 3.5 Contamination and Sequence Mismatches: A Dinosaur Protein Case Study; 4 Conclusions and Future Perspectives; References; Ancient RNA; 1 Introduction; 2 A Brief History of aRNA Study; 3 Diagenesis; 3.1 Migration and Loss; 3.2 Fragmentation; 3.3 Deamination; 3.4 Cross-linking; 3.5 Enzymatic Breakdown; 4 Perceived Information Value Compared to Ancient DNA; 5 Regulatory RNA; 6 RNA Genomes 7 Endogenous Transcriptomics8 Technical Considerations for aRNA; 8.1 Isolation of aRNA; 8.2 NGS Library Building; 8.3 Cytosine Deamination; 8.4 RNA Methylation; 9 Future Perspectives; 10 Conclusions; References; Ancient Epigenomics; 1 Introduction; 1.1 Defining Epigenetics; 1.2 The Biological Importance of Epigenetics; 1.3 Molecular Mechanisms Underlying Epigenetic Traits; 1.4 Detecting Epigenetic Marks; 1.5 Factors Influencing Epigenetic Changes; 1.6 Environment-Driven Epigenetic Changes; 2 Early Observations; 2.1 Indirect Indications; 2.2 Direct Observations; 3 The First Ancient Methylomes 3.1 The Paleo-Eskimo Saqqaq3.2 Archaic Hominins; 3.3 General Trends; 4 The First Ancient Nucleosome Maps; 5 Implications; 5.1 Sequencing Ancient DNA; 5.2 DNA Damage Models; 5.3 Tissue Specificity and Scarcity; 6 Conclusion and Future Perspectives; References; Part II: Paleogenomics Case Studies: From Ancient Pathogens to Primates; Ancient Pathogens Through Human History: A Paleogenomic Perspective; 1 Introduction; 2 Disease-Associated Pathogens and the Archaeological Record; 3 Using Ancient DNA to Reveal the Imprints of Pathogens
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2019
• Copyright Date: 2019
• Extent: 1 online resource
• Subjects: 560; Paleobiology; Genomics; NATURE / Animals / Dinosaurs & Prehistoric Creatures; NATURE / Fossils; SCIENCE / Paleontology; Electronic books
• Languages: English
• ISBNs: 9783030047535; 3030047539
• Related ISBNs: 9783030047528
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (EBSCO, viewed January 10, 2019).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.