Biobetters : protein engineering to approach the curative /: protein engineering to approach the curative. (2015)

• Record Type: Book
• Further Information: Note: Amy Rosenberg, Barthélemy Demeule, editors.
• Editors: Rosenberg, Amy; Demeule, Barthélemy
• Contents: Introduction -- Targeting glucocerebrosidase to macrophages for effective treatment of patients with Gaucher disease: setting the paradigm of a "fit for purpose" approach to enzyme replacement therapy -- Challenges of Enzyme Replacement Therapy: Poor tissue distribution in lysosomal diseases using Pompe disease as a model -- Muscle targeting -- Blood-Brain Barrier Targeting of Therapeutic Lysosomal Enzymes -- Novel Methods for Addressing Immunogenicity in Therapeutic Enzymes -- Structure of monoclonal antibodies -- Prediction of aggregation in vivo by studies of therapeutic proteins in human plasma -- Effect of Hydrolytic Degradation on the In Vivo Properties of Monoclonal Antibodies -- Oxidation of proteins in the in-vivo environment: what we know; what we need to study and potential mitigation strategies -- Molecular assessment: balancing affinity, PK and manufacturability -- Perspectives on engineering biobetter therapeutic proteins with greater stability in inflammatory environments -- Antibody-like molecules designed for superior targeting and pharmacokinetics -- Alternative protein scaffolds as novel biotherapeutics -- Current strategies for pharmacokinetic optimization -- Biosimilar and Biobetter Scenarios for the US and Europe: What Should We Expect? -- Regulatory considerations for approval of biobetter products.
• Publisher Details: New York : Springer
• Publication Date: 2015
• Extent: 1 online resource (xv, 378 pages), color illustrations
• Subjects: 660.6/3; Protein engineering; Proteins -- Biotechnology; Protein drugs; SCIENCE -- Chemistry -- Industrial & Technical; TECHNOLOGY & ENGINEERING -- Chemical & Biochemical; Protein drugs; Protein engineering; Proteins -- Biotechnology; Biomedicine; Pharmaceutical Sciences/Technology; Biomedicine general; Biotechnology; Protein Engineering; Electronic books
• Languages: English
• ISBNs: 9781493925438; 1493925431; 1493925423; 9781493925421
• Related ISBNs: 9781493925421
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (SpringerLink, viewed August 26, 2015).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.