Roles of host gene and non-coding RNA expression in virus infection. ([2018])

• Record Type: Book
• Further Information: Note: Ralph A. Tripp, S. Mark Tompkins, editors.
• Editors: Tripp, Ralph A; Tompkins, S. Mark
• Contents: Intro; Preface; Contents; 25 Host Factors in Coronavirus Replication; Abstract; 1 Introduction; 2 Host Receptors Involved in Coronavirus Entry; 3 Translation and the Unfolded Protein Response in Coronavirus-Infected Cells; 4 Coronavirus-Induced Modification of Host Cell Membranes; 5 Host Proteins Interacting with the Coronavirus Genome and Its Replication or Expression; 6 Host Innate Immune Responses Against Coronaviruses, and Viral Countermeasures; 7 Coronavirus-Induced Deregulation of the Cell Cycle; 8 The Role of Cyclophilins in Coronavirus Replication 9 Systems Biology Approaches to Identifying Host Factors in Coronavirus Replication10 Concluding Remarks; References; 26 Roles of Pro-viral Host Factors in Mosquito-Borne Flavivirus Infections; Abstract; 1 Introduction; 2 Anti- and Pro-viral Host Factors; 2.1 Attachment; 2.1.1 Glycosaminoglycans; 2.1.2 C-Type Lectin Receptors; 2.1.3 Phosphatidylserine Receptors; 2.1.4 Fc Receptors and Antibody-Dependent Enhancement of Attachment and Entry; 2.1.5 Other Receptor Types; 2.2 Endocytosis; 2.3 Uncoating; 2.4 Viral Translation; 2.4.1 Translation Initiation; 2.4.2 RNA Recruitment to the ER 2.4.3 Translation Elongation2.4.4 Translation Termination and Recycling; 2.4.5 Ribosomal Proteins; 2.4.6 Polyprotein Biogenesis and Processing; 2.5 Viral RNA Synthesis; 2.5.1 Replication Complex (RC) Formation and RNA Synthesis; 2.5.2 RNA-Binding Proteins; 2.6 Particle Assembly; 2.7 Particle Egress; 2.7.1 Glycosylation; 2.7.2 Furin-like Protease Cleavage; Acknowledgements; References; 29 Role of Innate Genes in HIV Replication; Abstract; 1 Introduction; 2 Sensors of the Innate Response; 2.1 TLR Sensors; 2.2 Cytosolic Sensors; 3 HIV-1 Utilizes or Avoids Cellular Factors to Escape Sensing 3.1 Cloaking of HIV-1 Cargo3.2 Exploitation of a Cellular Nuclease; 3.3 Active Exploitation of NLRX1; 3.3.1 NLRX1-A Regulator of Innate Signaling; 3.3.2 NLRX1-A Negative Regulator of HIV-1 Sensing; 3.3.3 Localization of NLRX1 and Signal Components; 3.3.4 Possible Impact of NLRX1 on Latent Reservoirs; 4 Restriction Factors as Effectors of the Innate Response; 5 SAMHD1-HIV-1 is Passively Avoiding Restriction; 5.1 Discovery of SAMHD1; 5.2 SAMHD1 Enzymatic Functions; 5.3 SAMHD1 Involved in Innate Immunity; 6 Conclusion; Acknowledgements; References 27 Host Factors Involved in Ebola Virus ReplicationAbstract; 1 Introduction; 2 Host Factors Required for Cell Entry and Fusion; 2.1 Attachment Factors; 2.2 Endosomal Uptake; 2.3 Glycoprotein Processing and Fusion; 3 Host Factors Required for Viral Transcription and Translation; 3.1 Viral Gene Expression and Genome Replication; 3.2 Viral Protein Synthesis; 4 Host Factors Required for Assembly and Egress; 5 Antagonism of Antiviral Responses; 5.1 Innate Immune Antagonism; 5.2 Adaptive Immune Antagonism; 6 Cell and Tissue-Specific Host Factors Involved in Pathogenesis; 7 Conclusion; References
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2018
• Extent: 1 online resource
• Subjects: 572.8/8; Viral genetics; Non-coding RNA; Electronic books
• Languages: English
• ISBNs: 9783030053697; 3030053695
• Related ISBNs: 9783030053680
• Notes: Note: Description based on online resource; title from digital title page (viewed on January 23, 2019).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.