Carbohydrate-based interactions at the molecular and the cellular level. (2018)

• Record Type: Book
• Further Information: Note: Kieran L. Hudson.
• Other Names: Hudson, Kieran L
• Contents: Intro; Supervisors' Foreword; Abstract; Parts of this thesis have been published in the following journal articles:; Acknowledgements; Contents; Abbreviations and Acronyms; List of Figures; List of Tables; List of Schemes; 1 Introduction; 1.1 Carbohydrates in Nature; 1.1.1 Carbohydrate Structure; 1.2 Protein-Carbohydrate Interactions; 1.2.1 The Roles and Importance of Protein-Carbohydrate Interactions in Nature; 1.2.2 Analysis of Protein-Carbohydrate Interactions; 1.2.3 The Molecular Basis of Protein-Carbohydrate Interactions; 1.2.4 Carbohydrate-Aromatic Interactions. 1.3 Scope of the Thesis Part I: Analysis of Protein-Carbohydrate Interactions in Protein Structures1.4 Tissue Engineering; 1.4.1 Tissue Engineering Scaffolds; 1.4.2 Hydrogels Derived from -Helical Peptides; 1.4.3 Functionalisation of Tissue Engineering Scaffolds; 1.4.4 Carbohydrates in Tissue Engineering; 1.5 Carbohydrate Synthesis; 1.5.1 Chemical Synthesis of Carbohydrates; 1.5.2 Enzymatic Synthesis of Carbohydrates; 1.6 Scope of the Thesis Part II: Tissue Engineering Scaffolds Functionalised with Carbohydrates; References. Part I Analysing Protein#x96;Carbohydrate Interactions at the Molecular Level2 Protein-Carbohydrate Interactions in Protein X-Ray Crystal Structures; 2.1 Identifying Carbohydrates in Protein Structures; 2.1.1 Using GlyVicinity to Determine Carbohydrate Identity; 2.1.2 Parsing the GlyVicinity Output; 2.1.3 Generating the Data Set of Carbohydrates with Proximal Amino Acids; 2.2 Analysis of the Composition and Distribution of Amino Acids Surrounding Carbohydrates; 2.3 Identifying CH- Interactions; 2.4 Validating the Quality of the Structural Data; 2.5 Comparison of Data for Ligands and Glycans. 3.5 Studies of Carbohydrate-Aromatic Interactions in the Solution Phase3.5.1 Influence of C-H Electronics on CH- Interactions; 3.5.2 Influence of Aromatic Electronics on CH- Interactions; References; Part II Carbohydrate-Modified Materials for Tissue Engineering; 4 The Modifiable Scaffold for Tissue Engineering; 4.1 The Structural Basis of hSAFs; 4.2 Peptide Synthesis and Hydrogel Preparation; 4.3 Characterisation and Properties of hSAFs; 4.4 Decoration of hSAFs with Functional Motifs; 4.4.1 Properties of the Modifiable and Modified Scaffold.
• Publisher Details: Cham : Springer
• Publication Date: 2018
• Extent: 1 online resource
• Subjects: 541.22; Molecular dynamics; Sugar -- Analysis; SCIENCE -- Chemistry -- Physical & Theoretical; Molecular dynamics; Sugar -- Analysis; Electronic books
• Languages: English
• ISBNs: 9783319777061; 3319777068
• Related ISBNs: 9783319777054; 331977705X
• Notes: Note: Online resource; title from PDF title page (EBSCO, viewed June 1, 2018).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.