Natural products as source of molecules with therapeutic potential : research & development, challenges and perspectives /: research & development, challenges and perspectives. ([2018])

• Record Type: Book
• Further Information: Note: Editor, Valdir Cechinel Filho.
• Editors: Cechinel-Filho, Valdir
• Contents: Intro; Dedication; Acknowledgments; Contents; About the Editor; Medicinal Plants and Phytomedicines; 1 Introduction; 2 Quality Control of Phytomedicines; 2.1 Quality and Efficacy of Plant Material; 2.2 Production Methods; 3 Medicinal Teas Today; 4 Modern Phytotherapy; 4.1 New Scientific Screening; 4.2 Mechanism of Action; 4.3 Synergy; 5 Some Selected Phytomedicines; 5.1 Ginkgo biloba (Ginkgo); 5.2 Serenoa repens (Saw Palmetto); 5.3 Valeriana officinalis (Valerian); 5.4 Hypericum perforatum (St. John's Wort); 5.5 Allium sativum (Garlic); 5.6 Piper methysticum; 5.7 Glycine max (Soy) 5.8 Matricaria chamomilla5.9 Maytenus ilicifolia; 5.10 Ilex paraguariensis; 5.11 Cynara scolymus L.; 5.12 Phyllanthus niruri; 6 Case Study: Development of the Phytomedicine from Biodiversity; 7 Conclusions; References; Plant Products with Antifungal Activity: From Field to Biotechnology Strategies; 1 Introduction; 2 Human Fungal Diseases; 3 Antifungal Susceptibility Methods; 3.1 Anti-Candida Plant Products; 3.2 Anti-dermatophytes Plant Products; 3.3 Anti-Malassezia Plant Products; 3.4 Anti-Aspergillus Plant Products; 3.5 Anti-Cryptococcus Plant Products 4 Production of Antimicrobials Through Plant Tissue Cultures4.1 Production of Antimicrobials Through Plant Cell Cultures; 4.2 Production of Antimicrobials Through Plant Organ Cultures; 4.3 Production of Antimicrobials Through Plantlets Propagated In Vitro; 5 Conclusions; References; Liquid Chromatography for Plant Metabolite Profiling in the Field of Drug Discovery; 1 Introduction; 2 Sample Preparation; 3 Development of the Metabolite Profile; 3.1 Thin-Layer Chromatography; 3.2 Column Chromatography; 3.3 Detectors; 3.3.1 Spectroscopic Detection; 3.3.2 Mass Spectrometric Detection; Ionization Mass AnalysisFragmentation; From MS Spectra to Compound Identification; 4 Pharmacological Evaluation; 5 Multivariate Data Handling of Chromatographic Fingerprints; 6 Applications of Metabolite Profile; 6.1 Linked to In Vitro Reaction Assays; 6.2 Linked to In Vitro Enzymatic Assays; 6.3 Linked to In Vivo Assays; 7 Conclusions; References; Functional Foods as Source of Bioactive Principles: Some Marked Examples; 1 Introduction; 2 Functional Foods; 2.1 Curcuma; 2.2 Garlic; 2.3 Omega-3; 2.4 Olive Oil; 2.5 Tea; 2.6 Ginger; 2.7 Broccoli; 2.8 Grape; 2.9 Black Pepper; 3 Probiotics; 3.1 Yogurt 3.2 Kefir3.3 Kombucha; 4 Prebiotics; 5 Synbiotics; 6 Conclusions; References; The Role of Flavonoids as Modulators of Inflammation and on Cell Signaling Pathways; 1 Introduction; 2 Absorption and Metabolism of Flavonoids; 3 Inflammation; 3.1 Inflammatory Mediators; 3.1.1 Nitric Oxide; 3.1.2 Arachidonic Acid Metabolites; 3.1.3 Cytokines; 3.1.4 Chemokines; 3.1.5 Cell Adhesion Molecules; 3.2 Inflammation-Associated Intracellular Signaling Pathways; 3.2.1 Nuclear Transcription Factor Kappa-B (NF-kB) Pathway; 3.2.2 Signal Transducer and Activator of Transcription (STAT) Protein Family
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2018
• Extent: 1 online resource
• Subjects: 615.1/9; Natural products; Biological products; Drug development; MEDICAL / Pharmacology; Biological products; Drug development; Natural products; Electronic books
• Languages: English
• ISBNs: 9783030005450; 3030005453
• Related ISBNs: 9783030005443
• Notes: Note: Online resource; title from PDF title page (EBSCO, viewed December 12, 2018).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.