HIV/AIDS-associated viral oncogenesis. ([2019])

• Record Type: Book
• Further Information: Note: Craig Meyers, editor.
• Other Names: Meyers, C (Craig)
• Contents: Intro; Contents; Overview; 1 AIDS-Associated Malignancies; Abstract; 1.1 Introduction; 1.2 Gammaherpesvirus-Associated Malignancies; 1.3 Human Papillomavirus-Associated Malignancies; 1.4 Conclusion; References; 2 Molecular Biology of KSHV in Relation to HIV/AIDS-Associated Oncogenesis; Abstract; 2.1 Introduction; 2.2 KSHV Primary Infection; 2.2.1 Attachment, Entry, and Cellular Receptors; 2.2.2 Internalization and Intracellular Trafficking; 2.2.3 Regulation of Cellular Signaling Pathways During Primary Infection 2.2.4 Viral Gene Expression During Primary Infection and the Establishment of Viral Latency2.3 KSHV Life Cycle; 2.3.1 The Latency Locus; 2.3.2 KSHV Latency and Latent Nuclear Antigen (LNA) or Latency-Associated Nuclear Antigen (LANA); 2.3.3 Epigenetic Silencing and Regulation of KSHV Latency; 2.3.4 Reactivation of KSHV from Latency; 2.3.5 Viral Genes Required for Reactivation; 2.3.6 Factors Involved in KSHV Reactivation; 2.4 KSHV and Immunity; 2.4.1 KSHV and Innate Immunity; 2.4.2 KSHV and Adaptive Immunity; 2.5 KSHV and Tumorigenesis 2.5.1 Models of KSHV-Induced Cellular Transformation and Tumorigenesis2.5.2 KSHV Viral Genes and Tumorigenesis; 2.5.3 Cellular Genes/Pathways in KSHV-Associated Malignancies; 2.6 KSHV and Inflammation; 2.6.1 Kaposi's Sarcoma: A Tumor Associated with Inflammation; 2.6.2 Latent Viral Factors Involved in Inflammation; 2.6.3 Viral Lytic Genes Involved in Inflammation; 2.7 KSHV and Metabolism; 2.7.1 KSHV Reprograms Glucose Metabolism; 2.7.2 KSHV Reprogramming of Glutamine Metabolism for Host Cell Proliferation and Survival; 2.7.3 KSHV Infection Induces Lipogenesis 2.7.4 KSHV Depends on Glycolysis, Glutaminolysis, and FAS for Lytic Replication2.8 Conclusion and Perspectives; References; 3 Kaposi's Sarcoma-Associated Herpesvirus (KSHV)-Associated Disease in the AIDS Patient: An Update; Abstract; 3.1 Introduction; 3.2 KSHV and the Development of KS; 3.3 KSHV and the Development of Lymphomas; 3.4 Prevalence of Viral Infection; 3.5 The KSHV Genome; 3.6 Molecular Biology of KSHV-Associated Disease; 3.7 Therapies to Treat KS, PEL, and MCD; 3.8 Conclusions; Acknowledgements; References 4 Molecular Biology of EBV in Relationship to HIV/AIDS-Associated OncogenesisAbstract; 4.1 Introduction; 4.2 The Host Pathways Affected by EBV in Oncogenesis; 4.2.1 Resistance to Cell Apoptosis; 4.2.2 Cell Cycle and Proliferation; 4.2.3 Promotion of Cell Metabolism; 4.2.4 Evasion from Immune Surveillance; 4.2.5 Epigenetic Regulation Due to EBV Infection; 4.3 The Functions of EBV Proteins During Oncogenesis; 4.4 HIV-Associated Lymphoma in HIV/AIDS Patients; 4.5 Conclusions; References; 5 Human Papillomavirus Infection and Cervical Cancer in HIV+ Women; Abstract
• Edition: Second edition
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2019
• Extent: 1 online resource
• Subjects: 616.99/4; AIDS malignancies; Carcinogenesis; AIDS malignancies; Carcinogenesis; Electronic books
• Languages: English
• ISBNs: 9783030035020; 3030035026
• Related ISBNs: 9783030035013; 3030035018
• Notes: Note: Description based on online resource; title from digital title page (viewed on February 15, 2019).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.