Systems thinking in medicine and new drug discovery. Volume two (2018)

• Record Type: Book
• Further Information: Note: By Robert E. Smith.
• Authors: Smith, Robert E, 1951-
• Contents: Intro; Contents; Preface; Chapter One; 1.1 P4 medicine: predictive, preventive, personalized and participatory; 1.2 Systems primary care medicine; 1.3 Causality in P4SM; 1.4 Explanation, prediction and control in P4 me; 1.5 What P4 medicine does; 1.6 Examples of P4 medicine; 1.7 Important collaborations in P4 medicine; 1.8 P4 and evidence based medicine; 1.9 The Advancing Regulatory Science Initiative; 1.10 The voices of the people; 1.11 Limitations of P4 medicine; 1.12 Metabolomics; 1.12.1 Introduction; 1.12.2 Comparison of LC-MS and GC-MS; 1.12.3 NMR in metabolomics 1.12.4 Receiver operator characteristic (ROC) curves1.12.5 Acute kidney injury (AKI) metabolomics; 1.12.6 Chronic kidney disease (CKD) me; 1.12.7 Metabolomics of acute kidney injury; 1.12.8 Metabolomics of neonatal, pediatric and childhood kidney diseases; 1.12.9 Metabolomics of kidney cancer; 1.12.10 Proteomics; 1.13 Targeted radiation therapy; 1.14 Precision systems medicine that targets cancer stem cel; 1.15 Cancer prevention; 1.16 Systems medicine; References; Chapter Two; 2.1 Previous misconceptions caused by reductionist thinking; 2.2 Chemistry of free radicals and RONS 2.3 How antioxidants really work2.3.1 Poorly liganded iron and the Fenton reaction; 2.3.2 The Nrf2/ARE system; 2.4 The role of the Keap1-Nrf2-ARE signaling system in preventing cardiovascular diseases; 2.5 Role of the Nrf2/ARE antioxidant system in cancer and neurodegenerative diseases; 2.6 Smoldering inflammation; 2.7 The complement system and toll-like receptors in health and disease; References; Chapter Three; 3.1 Nutrition; 3.1.1 Fats; 3.1.2 Protein; 3.1.3 Carbohydrates; 3.1.4 Vitamins and; 3.1.5 Mother's milk -- the only true superfood; 3.2 Role of Lifestyle; References; Chapter Four 4.1 Introduction4.2 Epigenetic gene regulation; 4.3 Global climate change; References; Appendix; A1 Introduction; A2 The Nervous System; A2.1 Introduction; A2.2 Cells in the nervous system; A2.3 Regions of the brain; A2.4 Neurotransmitters, neurohormones and neuromodulators; A2.5 Small molecule neuroactive NO and CO; A3 The Endocrine System; A4 The Immune System; References; Abbreviations and Acronyms Used; Index
• Publisher Details: Newcastle upon Tyne : Cambridge Scholars Publishing
• Publication Date: 2018
• Extent: 1 online resource (xiv, 333 pages), illustrations
• Subjects: 615.1/9; Drug development; Pharmaceutical chemistry; Integrative medicine; Human biology; Drug development; Human biology; Integrative medicine; Pharmaceutical chemistry; MEDICAL / Pharmacology; Electronic books
• Languages: English
• ISBNs: 9781527523777; 1527523772
• Related ISBNs: 1527506126; 9781527506121
• Notes: Note: Includes bibliographical references and index.; Note: Description based on online resource; title from PDF title page (EBSCO, viewed January 8, 2019).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.