Trypanosomatid diseases : molecular routes to drug discovery /: molecular routes to drug discovery. (2013)

• Record Type: Book
• Further Information: Note: Edited by Timo Jäger, Oliver Koch, Leopold Flohé.
• Editors: Jäger, Timo; (Pharmacist), Koch, Oliver; Flohé, L (Leopold), 1938-
• Contents: DISEASE BURDEN, CURRENT TREATMENTS, MEDICAL NEEDS AND STRATEGIC APPROACHES; Visceral leishmaniasis: current treatments and needs (Poonam Salotra, Ruchi Singh, Karin Seifert); Chemotherapy of Leishmaniasis. A Veterinary perspective (Maria Jesus Corral-Caridad, Jose Maria Alunda); Pharmacological metabolomics in trypanosomes (Darren J. Creek, Isabel M. Vincent, Michael P. Barrett); Drug design and screening by in silico approaches (Mattia Mori, Maurizio Botta); Computational Approaches and Collaborative Drug Discovery for Trypanosomal Diseases (Sean Ekins, Barry A. Bunin); METABOLIC PECULIARITIES IN THE TRYPANOSOMATID FAMILY GUIDING DRUG; Interaction of Leishmania parasites with host cells and its functional consequences (Uta Schurigt, Anita Masic, Heidrun Moll); The function of glycosomes in the metabolism of trypanosomatid parasites and the promise of glycosomal proteins as drug targets (Melisa Gualdron-Lopez, Paul A.M. Michels, Wilfredo Qui?ones, Ana J. Caceres, Luisana Avilan, Juan-Luis Concepcion); The glyoxalase enzymes in trypanosomatids (Marta Sousa Silva, Antonio E. N. Ferreira, Ricardo Gomes, Ana M. Tomas, Ana Ponces Freire, Carlos Cordeiro); The trypanothione-based redox metabolism of trypanosomatids (Marcelo A. Comini, Leopold Flohe); Thiol peroxidases of trypanosomatids (Helena Castro, Ana M. Tomas); Peroxynitrite as a cytotoxic effector against Trypanosoma cruzi: oxidative killing and antioxidant resistance mechanisms (Madia Trujillo, Maria Noel Alvarez, Lucia Piacenza, Martin Hugo, Gonzalo Peluffo, Rafael Radi); Selenoproteome of Kinetoplastids (Alexei V. Lobanov, Vadim N. Gladyshev); The Replication Machinery of Kinetoplast DNA (Rachel Bezalel-Buch, Nurit Yaffe, Joseph Shlomai); Life and death of Trypanosoma brucei: New perspectives for drug development (Torsten Barth, Jasmin Stein, Stefan Mogk, Caroline Schonfeld, Bruno K. Kubata, Michael Duszenko); VALIDATION AND SELECTION OF DRUG TARGETS IN KINETOPLASTS; Rational selection of antimicrobial drug targets: unique or conserved? (Boris Rodenko, Harry P. de Koning); Drug Targets in Trypanosomal and Leishmanial Pentose Phosphate Pathway (Marcelo A. Comini, Cecilia Ortiz, Juan Jose Cazzulo); GDP-mannose: a key point for target identification and drug design in kinetoplastids (S. Pomel, P.M. Loiseau); Transporters in antiparasitic drug development and resistance (Vincent Delespaux, Harry P. de Koning); Peptidases in autophagy are a therapeutic target for Leishmaniasis (Roderick A.M. Williams); Proteases of Trypanosoma brucei (Dietmar Steverding); EXAMPLES OF TARGET-BASED APPROACHES AND COMPOUNDS UNDER CONSIDERATION; Screening Approaches towards Trypanothione Reductase (Mathias Beig, Frank Oellien, Luise Krauth-Siegel, Paul M. Selzer); Redox-active agents in reactions involving the trypanothione/trypanothione reductase-based system to fight kinetoplastidal parasites (Gendron Thibault, Don Antoine Lanfranchi, Elisabeth Davioud-Charvet); Inhibition of trypanothione synthetase as therapeutic concept (Oliver Koch, Timo Jager, Leopold Flohe, Paul M. Selzer); Targeting the trypanosomatidic enzymes pteridine reductase and dihydrofolate reductase (Stefania Ferrari, Valeria Losasso, Puneet Saxena, Maria Paola Costi); Contribution to new therapies for Chagas? disease (Juan Patricia S. Doyle, C. Engel); Ergosterol Biosynthesis for the Specific Treatment of Chagas disease: From Basic Science to Clinical Trials (Julio A. Urbina); New Developments in the Treatment of Late Stage Human African Trypanosomiasis (Cyrus J. Bacchi, Robert T. Jacobs, Nigel Yarlett);
• Publisher Details: Place of publication not identified : Wiley-Blackwell
• Publication Date: 2013
• Extent: 1 online resource (576 pages)
• Subjects: 616.9363061; Trypanosomiasis -- Chemotherapy; Drug development
• Languages: English
• ISBNs: 9783527670406
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.