Antibiotics : targets, mechanisms and resistance /: targets, mechanisms and resistance. (©2014)

• Record Type: Book
• Further Information: Note: Edited by Claudio O. Gualerzi [and others].
• Other Names: Gualerzi, Claudio O, 1942-
• Contents: A chemist's survey of different antibiotic classes -- Antibacterial discovery: problems and possibilities -- Impact of microbial natural products on antibacterial drug discovery -- Antibiotics and resistance: a fatal attraction -- Fitness costs of antibiotic resistance -- Inhibitors of cell-wall synthesis -- Inhibitors of bacetrial cell partitioning -- The membrane as a novel target site for antibiotics to kill persisting bacterial pathogens -- Bacterial membrane, a key for controlling drug influx and efflux -- Interference with bacterial cell-to-cell chemical signaling in development of new anti-infectives -- Recent developments in inhibitors of bacterial type IIA topoisomerases -- Antibiotics targeting bacterial RNA polymerase -- Inhibitors targeting riboswitches and ribozymes -- Targeting ribonuclease P -- Involvement of ribosome biogenesis in antibiotic functions, acquired resistance, and future opportunities in drug discovery -- Aminoacyl-tRNA synthetase inhibitors -- Antibiotics targeting translation initiation in prokaryotes -- Inhibitors of bacterial elongation factor EF-Tu -- Aminoglycoside antibiotics: structural decoding of inhibitors targeting the ribosomal decoding A site -- Reptidyltransferase inhibitors of the bacterial ribosome -- Antibiotics inhibiting the translocation step of protein elongation on the ribosome -- Antibiotics at the ribosomal exit tunnel -- selected structual aspects -- Targeting HSP70 to fight cancer and bad bugs: one and the same battle?
• Publisher Details: Weinheim, Germany : Wiley-VCH
• Publication Date: 2014
• Copyright Date: 2014
• Extent: 1 online resource (xxiv, 549 pages), illustrations (some color)
• Subjects: 615.7/922; Antibiotics; Antibiotics -- Physiological effect; Antibiotics; Antibiotics -- Physiological effect; Drug Resistance, Microbial; Anti-Bacterial Agents; Anti-Bacterial Agents; Electronic books; Electronic book
• Languages: English
• ISBNs: 9783527659685; 3527659684; 1299854656; 9781299854659; 9783527659715; 3527659714; 9783527333059; 3527333053; 9783527659708; 3527659706; 9783527659692; 3527659692
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (Wiley, viewed November 4, 2013).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.