Therapeutic proteins : strategies to modulate their plasma half-lives /: strategies to modulate their plasma half-lives. (2012)

• Record Type: Book
• Further Information: Note: Edited by Roland Kontermann.
• Editors: Kontermann, Roland, 1961-
• Contents: General information -- Half-life modulating strategies : an introduction -- Pharmacokinetics and half-life of protein therapeutics -- Half-life extension through chemical and post-translational modifications -- Half-life extension through PEGylation -- Half-life extension of therapeutic proteins via genetic fusion to recombinant PEG mimetics -- Half-life extension through O-glycosylation -- Polysialic acid and polysialylation to modulate antibody pharmacokinetics -- Half-life extension through HESylation -- Half-life modulation involving recycling by the neonatal Fc receptor -- The biology of the neonatal Fc receptor (FcRn) -- half-life extension by fusion to the Fc region -- Monomeric Fc fusion technology: an approach to create long-lasting clotting factors -- The diverse roles of FcRn: implications for antibody engineering -- Half-life extension by fusion to recombinant albumin -- AlbudAb technology platform: versatile albumin binding domains for the development of therapeutics with tunable half-lives -- Half-life extension by binding to albumin through an albumin binding domain -- Half-life extension by binding to albumin through small molecules -- Half-life extension with pharmaceutical formulations -- Half-life extension with pharmaceutical formulations: liposomes -- Half-life extension with pharmaceutical formulations: nanoparticles by the miniemulsion process.
• Publisher Details: Weinheim, Germany : Wiley-Blackwell, an imprint of John Wiley & Sons
• Publication Date: 2012
• Copyright Date: 2012
• Extent: 1 online resource (374 pages), illustrations (some color)
• Subjects: 615.3; Protein drugs -- Design; Proteins -- Therapeutic use; Proteins -- pharmacokinetics; Half-Life; MEDICAL -- Pharmacology; Protein drugs -- Design; Proteins -- Therapeutic use; Electronic books; Electronic book
• Languages: English
• ISBNs: 9783527644827; 3527644822; 9783527644797; 3527644792; 9783527644780; 3527644784; 9783527644803; 3527644806; 9781283454223
• Related ISBNs: 128345422X; 9783527328499; 3527328491
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from resource home page (ebrary, viewed on June 17, 2014).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.