Systems thinking in medicine and new drug discovery. Volume one (2018)
- Record Type:
- Book
- Title:
- Systems thinking in medicine and new drug discovery. Volume one (2018)
- Main Title:
- Systems thinking in medicine and new drug discovery.
- Further Information:
- Note: By Robert E. Smith.
- Authors:
- Smith, Robert E, 1951-
- Contents:
- Intro; Contents; Preface; Chapter One; 1.1 Introduction; 1.2 Reductionist Thinking and DNA; 1.3 Systems Thinking; 1.3.1 Definition and the importance of change; 1.3.2 Misconceptions that are clarified by systems thinking; 1.3.3 Characteristics of systems thinking; 1.3.4 The roots of systems thinking; 1.3.5 Autopoiesis and Gaia; 1.3.6 Systems view of autopoiesis and stem cells; 1.3.7 The importance of networks in life; 1.3.8 Genetics and systems thinking; 1.3.9 Nonlinearity and rhythms in living systems; 1.3.10 The -omics, from genomics to personal -omics 1.3.11 A multidimensional, non-linear view of diseases1.3.12 Drugs that bind to multiple targets; 1.3.13 Modularity of biological networks; 1.3.14 Going beyond genomics and looking for hidden connections; 1.3.15 Tools for understanding metabolism better; 1.3.16 Evidence based medicine and the Critical Path Initiative; 1.3.17 Cancer Genome Characterization Initiative, CGCI; 1.3.18 Systems-based thinking in education, in contrast with reductionist thinking inadvertisements and propaganda; 1.4 More systems thinking is needed; 1.5 Reductionist thinking is still useful; References; Chapter Two 2.1 The human ecosystem, holobionts, hologenome and viruses2.2 The widespread existence of microbes in the human body; 2.3 Gut microbiome and the enteric nervous system (ENS; 2.3.1 Composition of the gut micr; 2.3.2 Interactions and communication between the ENS and the rest of the body; 2.3.3 Communication between the gut microbiome, ENS,Intro; Contents; Preface; Chapter One; 1.1 Introduction; 1.2 Reductionist Thinking and DNA; 1.3 Systems Thinking; 1.3.1 Definition and the importance of change; 1.3.2 Misconceptions that are clarified by systems thinking; 1.3.3 Characteristics of systems thinking; 1.3.4 The roots of systems thinking; 1.3.5 Autopoiesis and Gaia; 1.3.6 Systems view of autopoiesis and stem cells; 1.3.7 The importance of networks in life; 1.3.8 Genetics and systems thinking; 1.3.9 Nonlinearity and rhythms in living systems; 1.3.10 The -omics, from genomics to personal -omics 1.3.11 A multidimensional, non-linear view of diseases1.3.12 Drugs that bind to multiple targets; 1.3.13 Modularity of biological networks; 1.3.14 Going beyond genomics and looking for hidden connections; 1.3.15 Tools for understanding metabolism better; 1.3.16 Evidence based medicine and the Critical Path Initiative; 1.3.17 Cancer Genome Characterization Initiative, CGCI; 1.3.18 Systems-based thinking in education, in contrast with reductionist thinking inadvertisements and propaganda; 1.4 More systems thinking is needed; 1.5 Reductionist thinking is still useful; References; Chapter Two 2.1 The human ecosystem, holobionts, hologenome and viruses2.2 The widespread existence of microbes in the human body; 2.3 Gut microbiome and the enteric nervous system (ENS; 2.3.1 Composition of the gut micr; 2.3.2 Interactions and communication between the ENS and the rest of the body; 2.3.3 Communication between the gut microbiome, ENS, brain and immune system; 2.3.4 The gut microbiota and ENS comprise an entero endocrine organ; 2.4 The role of the gut microbiome in preventing diseases; 2.5 The role of gut microbiome dysbiosis in causing diseases; 2.5.1 The importance of biodiversity 2.5.2 The gut microbiome and inflammation2.5.3 The benefits of vegan and vegetarian diets; 2.5.4 The gut microbiome and cardiovascular diseases; 2.5.5 The role of the gut microbiome in stress, anxiety and neurodegenerative diseases; 2.5.6 The importance of healthy microbiota in obtaining an effective response to vaccines; 2.5.7 The importance of oral health and preventing periodontal disease; 2.6 Factors affecting the composition of the microbiome; 2.7 Viruses are important, too; 2.8 Eukarya in the human microbiome; 2.8.1 Introduction to the microbial eukaryotic cells in the human microbiome 2.8.2 Fungi2.8.3 Protozoa and intestinal worms (helminths); References; Chapter Three; 3.1 How new drugs are developed; 3.1.1 Select a Disease; 3.1.2 Select a therapeutic target or phenotype; 3.1.3 Find a lead compound; 3.1.4 Improve the lead compound; 3.1.5 Drug delivery; 3.1.6 Manufacturing and cGMP; 3.1.7 Clinical trials; 3.1.8 Many drugs that were developed and approved had a single therapeutic target; 3.1.9 Combinations of drugs are also used and are being developed; 3.1.10 Some targets are now known to have formerly unexpected biological roles … (more)
- Publisher Details:
- Newcastle upon Tyne : Cambridge Scholars Publishing
- Publication Date:
- 2018
- Copyright Date:
- 2018
- Extent:
- 1 online resource (xv, 616 pages), illustrations
- Subjects:
- 615.1/9
Pharmacology
Drug development
Pharmaceutical chemistry
Integrative medicine
Human biology
Drug Discovery
Drug development
Human biology
Integrative medicine
Pharmaceutical chemistry
MEDICAL / Pharmacology
Medical toxicology
Cybernetics & systems theory
Electronic books - Languages:
- English
- ISBNs:
- 9781527523661
1527523667 - Related ISBNs:
- 1527506096
9781527506091 - Notes:
- Note: Includes bibliographical references and index.
Note: Print version record. - Access Rights:
- Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
- Access Usage:
- Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library HMNTS - ELD.DS.375233
- Ingest File:
- 02_355.xml