Hereditary colorectal cancer : genetic basis and clinical implications /: genetic basis and clinical implications. ([2018])

• Record Type: Book
• Further Information: Note: Laura Valle, Stephen B. Gruber, Gabriel Capellá, editors.
• Editors: Valle, Laura; Gruber, Stephen B; Capellá, Gabriel
• Contents: Part1 : GENETIC CAUSES AND ASSOCIATED PHENOTYPES- Lynch syndrome -- The molecular basis of Lynch-like syndrome -- Constitutional mismatch repair deficiency -- Mismatch repair proficient hereditary non-polyposis colorectal cancer -- Genetic and environmental modifiers of risk in Lynch syndrome -- ADENOMATOUS POLYPOSIS SYNDROMES- Introduction -- Familial adenomatous polyposis -- Polymerase proofreading-associated polyposis -- MUTYH-associated polyposis -- NTHL1-associated polyposis -- Germline biallelic inactivation of MMR genes (with polyposis phenotype) -- Unexplained adenomatous polyposis -- HAMARTOMATOUS POLYPOSIS SYNDROMES- Peutz-Jeghers syndrome -- Juvenile polyposis syndrome -- PTEN-hamartoma tumor syndromes -- Other hamartomatous polyposis conditions -- HEREDITARY MIXED POLYPOSIS SYNDROME -- SERRATED POLYPOSIS SYNDROME -- Part2: GENETIC DIAGNOSTICS and CLINICAL MANAGEMENT -- Genetic testing in hereditary colorectal cancer -- Universal tumor screening for Lynch syndrome -- Classification of genetic variants. Prediction models for Lynch syndrome -- Surveillance guidelines for hereditary colorectal cancer syndromes -- Surgical management of hereditary colorectal cancer syndromes -- Chemoprevention in hereditary colorectal cancer syndromes -- Immunotherapy in hereditary colorectal cancer -- The Immune Biology of Microsatellite Unstable cancer -- Hereditary colorectal cancer: Immunotherapy approaches -- Medical oncology management of hereditary colorectal cancer. Part3: REGISTRIES and DATABASES -- Databases: intentions, capabilities and limitations -- The Colon Cancer Family Registry Cohort -- The Prospective Lynch Syndrome Database -- The InSiGHT Database: An example LOVD system -- The International Mismatch Repair Consortium.
• Publisher Details: Cham : Springer
• Publication Date: 2018
• Copyright Date: 2018
• Extent: 1 online resource, illustrations (some color)
• Subjects: 616.99/4042; Medicine; Colon (Anatomy) -- Cancer -- Genetic aspects; Rectum -- Cancer -- Genetic aspects; Cancer genes; HEALTH & FITNESS -- Diseases -- General; MEDICAL -- Clinical Medicine; MEDICAL -- Diseases; MEDICAL -- Evidence-Based Medicine; MEDICAL -- Internal Medicine; Cancer genes; Colon (Anatomy) -- Cancer -- Genetic aspects; Rectum -- Cancer -- Genetic aspects; Biomedicine; Gene Function; Oncology; Cancer Research; Medical -- Oncology; Oncology; Medical genetics; Oncology ; Oncology; Medical -- Genetics; Medical genetics; Electronic books
• Languages: English
• ISBNs: 9783319742595; 3319742590
• Related ISBNs: 9783319742588; 3319742582
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (EBSCO, viewed May 9, 2018).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.