Heat shock proteins in the immune system. (2018)
- Record Type:
- Book
- Title:
- Heat shock proteins in the immune system. (2018)
- Main Title:
- Heat shock proteins in the immune system
- Further Information:
- Note: Robert J. Binder, Pramod K. Srivastava, editors.
- Editors:
- Binder, Robert J
Srivastava, Pramod K - Contents:
- Intro; Introduction and History; Contents; Part I: Structure of the HSPs in Relation to Chaperoning Peptides and Proteins; Chapter 1: Hsp70-Substrate Interactions; 1.1 Introduction; 1.2 Hsp70 Functional Cycle; 1.3 Structural Basis for Hsp70-Substrate Interactions; 1.4 Mechanism of Action of Hsp70 Chaperones; 1.5 Interactions of Hsp70 Chaperones with Protein Substrates; 1.6 Role of Co-Chaperones; 1.7 Concluding Remarks; References; Chapter 2: Molecular Chaperone Inhibitors; 2.1 The Hsp70 and Hsp90 Chaperone Cycle; 2.2 Hsp90 Inhibitors and Their Binding Sites; 2.2.1 Hsp90 N-Terminal Inhibitors. 2.2.2 Benzoquinone Ansamycin Inhibitors2.2.3 Radicicol and Analogous Inhibitors; 2.2.4 Additional Hsp90 Second-Generation Inhibitors; 2.2.5 Consequences of Different N-Terminal Inhibitors for Hsp90 Specificity and Conformation; 2.2.6 Hsp90 C-Terminal Inhibitors; 2.3 Grp94; 2.3.1 Allosteric Inhibitors of Grp94; 2.4 Hsp90 Co-Chaperone Inhibitors; 2.5 Hsp70/Hsc70; 2.6 Hsp70/Hsc70 Inhibitors and Their Binding Sites; 2.6.1 ATP-Competitive Inhibitors of Hsp70/Hsc70; 2.6.2 Allosteric Inhibitors of Hsp70/Hsc70; 2.6.3 Peptide Mimetics Targeting Hsp70/Hsc70; 2.7 Hsp40; 2.8 Small Hsps-Hsp27. 2.8.1 Antisense Oligonucleotides Targeting Hsp272.9 Small Hsps: Clusterin; 2.9.1 Antisense Oligonucleotides Targeting Clusterin; References; Part II: Exposure of HSPs to Immune Cells; Chapter 3: Extracellular Heat Shock Proteins as Stress Communication Signals; 3.1 Introduction; 3.2 Types of CellularIntro; Introduction and History; Contents; Part I: Structure of the HSPs in Relation to Chaperoning Peptides and Proteins; Chapter 1: Hsp70-Substrate Interactions; 1.1 Introduction; 1.2 Hsp70 Functional Cycle; 1.3 Structural Basis for Hsp70-Substrate Interactions; 1.4 Mechanism of Action of Hsp70 Chaperones; 1.5 Interactions of Hsp70 Chaperones with Protein Substrates; 1.6 Role of Co-Chaperones; 1.7 Concluding Remarks; References; Chapter 2: Molecular Chaperone Inhibitors; 2.1 The Hsp70 and Hsp90 Chaperone Cycle; 2.2 Hsp90 Inhibitors and Their Binding Sites; 2.2.1 Hsp90 N-Terminal Inhibitors. 2.2.2 Benzoquinone Ansamycin Inhibitors2.2.3 Radicicol and Analogous Inhibitors; 2.2.4 Additional Hsp90 Second-Generation Inhibitors; 2.2.5 Consequences of Different N-Terminal Inhibitors for Hsp90 Specificity and Conformation; 2.2.6 Hsp90 C-Terminal Inhibitors; 2.3 Grp94; 2.3.1 Allosteric Inhibitors of Grp94; 2.4 Hsp90 Co-Chaperone Inhibitors; 2.5 Hsp70/Hsc70; 2.6 Hsp70/Hsc70 Inhibitors and Their Binding Sites; 2.6.1 ATP-Competitive Inhibitors of Hsp70/Hsc70; 2.6.2 Allosteric Inhibitors of Hsp70/Hsc70; 2.6.3 Peptide Mimetics Targeting Hsp70/Hsc70; 2.7 Hsp40; 2.8 Small Hsps-Hsp27. 2.8.1 Antisense Oligonucleotides Targeting Hsp272.9 Small Hsps: Clusterin; 2.9.1 Antisense Oligonucleotides Targeting Clusterin; References; Part II: Exposure of HSPs to Immune Cells; Chapter 3: Extracellular Heat Shock Proteins as Stress Communication Signals; 3.1 Introduction; 3.2 Types of Cellular Communication; 3.3 Extracellular HSP as Communication Signals; 3.4 Extracellular HSP in Pathological Conditions; 3.5 Mechanisms of HSP Export; 3.6 The Stress Observation System; 3.7 Conclusions; References; Part III: Regulation of Immune Responses by Extracellular HSPs. Chapter 4: The Heat Shock Protein-CD91 Pathway and Tumor Immunosurveillance4.1 Heat Shock Proteins as Chaperones of Macromolecules; 4.2 Immune Responses Elicited by Extracellular HSPs; 4.3 Extracellular HSPs as the Molecular Signature for Immunological Responsiveness; 4.4 The Role of Extracellular HSPs in Tumor Immunosurveillance; 4.5 Conclusion; References; Chapter 5: Bridging the Gaps in the Vaccine Development: Avant-Garde Vaccine Approach with Secreted Heat Shock Protein gp96-Ig; 5.1 Introduction. 5.2 The Visionary Work of Dr. Eckhard Podack and Development of the State-of-the-Art Secreted gp96-Ig Vaccine Approach5.2.1 Construction of gp96-Ig; 5.2.2 Principles of Secreted gp96-Ig Vaccine Approach; 5.3 The State of the Knowledge of Antitumor Vaccination with gp96-Ig; 5.3.1 Allogeneic gp96 Vaccine; 5.3.2 Combined Therapeutic Approach; 5.4 The State of Knowledge of Anti-Infectious Vaccination with gp96-Ig; 5.4.1 Secreted SIV/HIV gp96-Ig Vaccine; 5.4.1.1 Gp96SIVIg as a Novel Adjuvant for Antibody Production. … (more)
- Publisher Details:
- Cham : Springer
- Publication Date:
- 2018
- Extent:
- 1 online resource
- Subjects:
- 572.6
Medicine
Heat shock proteins
Immune system
SCIENCE -- Life Sciences -- Biochemistry
Heat shock proteins
Immune system
Heat-Shock Proteins -- immunology
Biomedicine
Immunology
Protein Science
Infectious Diseases
Cancer Research
Medical -- Infectious Diseases
Medical -- Oncology
Proteins
Infectious & contagious diseases
Oncology
Immunology
Biochemistry
Emerging infectious diseases
Oncology
Medical -- Immunology
Immunology
Electronic books - Languages:
- English
- ISBNs:
- 9783319690421
3319690426 - Related ISBNs:
- 9783319690407
331969040X - Notes:
- Note: Includes bibliographical references and index.
Note: Online resource; title from PDF title page (EBSCO, viewed April 16, 2018). - Access Rights:
- Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
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- Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.
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- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library HMNTS - ELD.DS.375102
- Ingest File:
- 02_355.xml