PARP inhibitors for cancer therapy. ([2015])

• Record Type: Book
• Further Information: Note: Nicola J. Curtin, Ricky A. Sharma, editors.
• Editors: Curtin, Nicola J; Sharma, Ricky A
• Contents: History of the discovery of poly (ADP-ribose) -- Discovery of the PARP superfamily and focus on the lesser exhibited but not lesser talented members -- The role of PARPs in DNA Strand Break Repair -- TIPs: Tankyrase Interacting Proteins -- PARP and Carcinogenesis -- Multitasking roles for poly(ADP-ribosyl)ation in aging and longevity -- Overview of PARP Inhibitor Design and Optimization -- Structure Based Design of PARP Inhibitors -- Preclinical chemosensitization by PARP inhibitors -- Classification of PARP inhibitors based on PARP trapping and catalytic inhibition, and rationale for combinations with topoisomerase I inhibitors and alkylating agents -- Radiosensitisation by poly(ADP-ribose) polymerase inhibition -- The vasoactivity of PARP inhibitors -- Synthetic lethality with Homologous Recombination Repair defects -- Targeting tumour hypoxia with PARP Inhibitors: Contextual synthetic lethality -- Other determinants of sensitivity -- Synthetic sickness with molecularly targeted agents against the EGFR pathway -- Disruption of DNA repair by cell cycle and transcriptional CDK inhibition -- Resistance to PARP Inhibitors Mediated by Secondary BRCA1/2 Mutations -- PARP inhibitor resistance -- what is beyond BRCA1 or BRCA2 restoration -- Introduction to PARPi clinical trials and future directions -- Clinical trials investigating PARP inhibitors as single agents -- Clinical trials of PARP inhibitors with chemotherapy -- Combination of PARP inhibitors with clinical radiotherapy -- Biomarkers for PARP Inhibitors.
• Publisher Details: Cham : Humana Press Springer
• Publication Date: 2015
• Copyright Date: 2015
• Extent: 1 online resource (xix, 591 pages)
• Subjects: 615.19; Medicine; NAD-ADP-ribosyltransferase -- Inhibitors -- Therapeutic use; Enzyme inhibitors -- Therapeutic use; Cancer -- Treatment; MEDICAL -- Pharmacology; Cancer -- Treatment; Enzyme inhibitors -- Therapeutic use; Medicine; Health & Biological Sciences; Oncology; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases -- therapeutic use; Science -- Life Sciences -- Biology -- Molecular Biology; Pharmacology; Medical research; Oncology; Drug interactions; Medical -- Oncology; Oncology; Electronic books
• Languages: English
• ISBNs: 9783319141510; 3319141511; 3319141503; 9783319141503
• Related ISBNs: 9783319141503
• Notes: Note: Includes bibliographical references and index.; Note: Vendor-supplied metadata.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.