Critical issues in head and neck oncology : key concepts from the sixth THNO Meeting /: key concepts from the sixth THNO Meeting. ([2018])

• Record Type: Book
• Further Information: Note: Jan B. Vermorken [and 5 others], editors.
• Editors: Vermorken, Jan B
• Other Names: Trends in Head and Neck Oncology (Conference), 6th
• Contents: Intro; Preface; Contents; Part I: Epidemiology and Diagnosis; The Role of Vaccination in the Prevention of Head and Neck Cancer; Introduction; HPV Vaccines; Early End-Points; Herd Effects; The Effect of Vaccinating Boys on Cancer in Men; Vaccination Coverage and Programme Resilience; Economic Considerations; Conclusions; References; Cellular and Molecular Pathology in Head and Neck Cancer; Introduction; International Datasets and the WHO Classification; Molecular Sequencing; Stromal Factors; Immunological Landscape; Digital Pathology and Image Analysis; Biomarkers in Current Practice. Molecular Pathology and Salivary DiagnosticsReferences; Part II: Prediction of Outcome; Oncogenomics/Proteomics of Head and Neck Cancer; Oncoproteomics; Head and Neck Cancer Classification; Anatomical Classification of Head and Neck Cancers; Genetic Subclassification; HPV−ve Tumors; HPV+ve Tumors; Tumor Classifications by Oncogenomics; References; Targeted Next-Generation Sequencing in Head and Neck Cancer; Optimization of Cancer Treatment Based on Cancer Genomics; Targeted Therapy of Head and Neck Cancer; Comprehensive NGS Studies Reveal a Complex Genetic Landscape in HNSCC Precision Oncology by Targeted Panel SequencingExploiting NGS Results for the Clinical Development of Targeted Therapies; Intratumoral Genomic Heterogeneity in HNSCC: A Challenge for Personalized Medicine?; Conclusions; References; Homologous Recombination Repair Function as a Predictor of Treatment Response; Introduction; Molecular Responses to Radiation-/Chemoradiation-Induced DNA Damage; Measuring HRR Function to Predict Response to Radiotherapy/Chemoradiotherapy; Targeting HRR Function to Sensitise Tumors to Radiotherapy/Chemoradiotherapy. Targeting G2/M Checkpoint Control Through ATR or Chk1 InhibitionATR Inhibitors; Chk1 Inhibitors; Conclusions; References; Part III: Oral Cavity Cancer; Surgical Management of Oral Cavity Cancer; Introduction; Tumor Factors; Patient Factors; Other Factors; Surgical Access to Oral Cancer; Outcome; References; Reconstruction in the Oral Cavity: When and How; Introduction; Reconstruction of Soft Tissue Defects; Tongue and Floor of Mouth Defects; Aims of Treatment; Options for Treatment; Buccal Mucosa Defects; Aims of Treatment; Options for Treatment; Post-operative Care; Soft Palate Defects. Aims of TreatmentOptions for Treatment; Reconstruction of Bony Defects; Mandibular Defects; Choice of Flaps for Mandibular Reconstruction; Maxillary Defects; Options for Reconstruction; Choice of Flaps for Maxillary Reconstruction; Dental Rehabilitation; Conclusions; References; Induction Chemotherapy: Does It Have a Place in Oral Cavity Cancer?; Data from Meta-Analyses; Induction Chemotherapy for "Unresectable" or "Unresected" Oral Cavity Cancer; Induction Chemotherapy Before Surgery for Oral Cavity Cancer: Randomized Trials; Conclusions; References.
• Publisher Details: Cham, Switzerland : Springer Nature
• Publication Date: 2018
• Extent: 1 online resource
• Subjects: 616.99491; Medicine; Head -- Cancer -- Congresses; Neck -- Cancer -- Congresses; HEALTH & FITNESS -- Diseases -- General; MEDICAL -- Clinical Medicine; MEDICAL -- Diseases; MEDICAL -- Evidence-Based Medicine; MEDICAL -- Internal Medicine; Medical -- Radiology & Nuclear Medicine; Medical -- Oncology; Radiotherapy; Oncology; Oncology ; Radiotherapy; Oncology; Electronic books
• Languages: English
• ISBNs: 9783319988542; 3319988549
• Related ISBNs: 9783319988535
• Notes: Note: Includes bibliographical references and index.; Note: Description based on online resource; title from digital title page (viewed on December 13, 2018).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.