Mechanisms of molecular carcinogenesis. Volume 1 (2017)

• Record Type: Book
• Further Information: Note: Johannes Haybaeck, editor.
• Editors: Haybaeck, Johannes
• Contents: Preface; Contents; 1: The Endocannabinoid System in Carcinogenesis; 1.1 The Endocannabinoid System and Its Components; 1.2 The Endocannabinoid System and Cancer; 1.3 Receptors of the Endocannabinoid System Involved in Carcinogenesis; 1.4 Mechanisms of Anti-tumorigenic Effects by Cannabinoids/Endocannabinoids; 1.4.1 Apoptosis; 1.4.2 Autophagy; 1.4.3 Cell Proliferation and Cell Cycle Arrest; 1.4.4 Metastasis; 1.5 Anti-tumorigenic Effects of Cannabinoids/Endocannabinoids: Non-CB Receptor-Mediated; 1.6 Potential Pro-tumorigenic Effects of the Endocannabinoid System; 1.7 Synopsis. 2.3.1 MACC1 as Cancer Inducer2.3.2 MACC1 as Prognostic Marker; 2.3.3 MACC1 as Predictive Marker; 2.3.4 MACC1 as Druggable Target; 2.4 Outlook; References; 3: Axl and Its Mediated Signaling Axis in Cancer; 3.1 Axl Structure, Stimuli, and Expression; 3.1.1 Discovery and Structure of Axl; 3.1.2 Activation of Axl Signaling; 3.1.3 Axl Is Upregulated in Cancer; 3.2 Axl-Mediated Hallmarks of Cancer; 3.2.1 Axl Signaling in Cell Proliferation; 3.2.2 Antiapoptotic Functions of Axl Signaling; 3.2.3 Axl Signaling Induces Angiogenesis. 3.2.4 Axl Signaling Induces Epithelial-Mesenchymal Transition3.2.5 Axl Signaling in Cancer Metastasis; 3.2.6 Axl in Cancer Stemness; 3.3 Axl as Regulator of Drug Resistance in Cancer; References; 4: Insulin Signaling Linking Metabolism and Malignancy; 4.1 Introduction; 4.2 IGF1 in Cancer; 4.3 IGF2 in Cancer; 4.4 Insulin and IGF Signaling and Its Implication in Carcinogenesis; 4.4.1 Insulin Receptors, IGF Receptors, and Hybrid Receptors; 4.4.2 Insulin Receptor Substrates; 4.4.3 PI3K-Related Signaling; 4.4.4 MAPK-Related Signaling; References.
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2017
• Extent: 1 online resource
• Subjects: 616.99/4071; Medicine; Carcinogenesis -- Molecular aspects; HEALTH & FITNESS -- Diseases -- General; MEDICAL -- Clinical Medicine; MEDICAL -- Diseases; MEDICAL -- Evidence-Based Medicine; MEDICAL -- Internal Medicine; Carcinogenesis -- Molecular aspects; Biomedicine; Cancer Research; Oncology; Molecular Medicine; Cytokines and Growth Factors; Gene Expression; Medical -- Oncology; Science -- Life Sciences -- Biology -- Molecular Biology; Science -- Life Sciences -- Biochemistry; Medical -- Genetics; Oncology; Medical research; Cellular biology (cytology); Medical genetics; Oncology; Oncology ; Cytokines; Gene expression; Electronic books
• Languages: English
• ISBNs: 9783319536590; 3319536591; 3319536575; 9783319536576
• Related ISBNs: 9783319536576; 3319536605; 9783319536606
• Notes: Note: Includes bibliographical references.; Note: Online resource; title from PDF title page (SpringerLink, viewed June 7, 2017).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.