Blue biotechnology : from gene to bioactive product /: from gene to bioactive product. (2017)

• Record Type: Book
• Further Information: Note: Werner E.G. Müller, Heinz C. Schröder, Xiaohong Wang, editors.
• Editors: Müller, Werner E. G; Schröder, Heinz C; Professor Dr, Wang, Xiaohong
• Contents: Preface; Contents; Contributors; 1 35 Years of Marine Natural Product Research in Sweden: Cool Molecules and Models from Cold Waters; Abstract; 1 Natural Product Research; 2 Marine Natural Product Research, a Field on the Rise; 3 Cold Waters, from the Shallow to the Deep; 4 Swedish Cold Waters; 5 The Emergence of Marine Pharmacognosy in Sweden; 6 Discovery of the Barettins from the Deep-Sea Sponge Geodia barretti; 7 Geodia barretti-A Sponge Model for Sponge Ground Investigations; 8 Cold-Water Temperatures Still Produce Cool Chemistry; 9 Interpretation, Prediction and Selection; 10 Conclusion. AcknowledgementsReferences; 2 Major Antimicrobial Representatives from Marine Sponges and/or Their Associated Bacteria; Abstract; 1 Introduction; 2 Antimicrobial Compounds from Marine Sponges; 2.1 Lipids; 2.2 Polyketides; 2.3 Steroids; 2.4 Terpenoids; 2.5 Alkaloids; 2.6 Peptides; 2.7 Miscellaneous Brominated Derivatives; 3 Antimicrobial Compounds from Sponge-Associated Bacteria; 4 Conclusions and Future Challenges; Bibliography; 3 Discovery and Development of Novel Drugs; Abstract; 1 Introduction; 2 Project Planning Phase; 3 Where to Start?; 4 Drug Discovery. 4.1 Chemical Tactics-Where to Get First Hits?4.2 Biological Tactics-Screening Cascade; 5 Drug Development; 6 Preclinical Development; 7 Clinical Development; 8 Non-clinical Development; References; 4 Computer-Aided Drug Discovery from Marine Compounds: Identification of the Three-Dimensional Structural Features Responsible for Antimalarial Activity; Abstract; 1 Introduction; 2 Materials and Methods: Molecular Modeling Studies; 3 Identification of the Three-Dimensional Structural Features Responsible for the Antimalarial Activity; 3.1 First Series of New Synthetic Analogues of Plakortin. 3.2 Second Series of New Synthetic Analogues of Plakortin3.3 New Natural Polyketide Endoperoxides; 3.4 Synthetic Analogs of Aplidinone A and B; 4 Conclusion; Acknowledgments; References; 5 Bluegenics: Bioactive Natural Products of Medicinal Relevance and Approaches to Their Diversification; Abstract; 1 History of Natural Products in Medicine; 2 The Role of Natural Products in Nature; 3 The Antibiotic Crisis and the Need for New Medicine; 4 Antibiotic Resistance; 5 Natural Products and the Clinic. Towards New Antibiotics in the Battle Against Resistance. 6 A Growing Focus on Marine Natural Products7 Generating Natural Product Analogues; 7.1 Total Synthesis; 7.2 Semisynthesis; 7.3 Precursor-Directed Biosynthesis; 7.4 Mutasynthesis; 7.5 Combinatorial Biosynthesis; 7.6 Genochemetics: gene expression enabling synthetic diversification; 8 Concluding Remarks and Future Perspective; References; 6 New Target Sites for Treatment of Osteoporosis; Abstract; 1 Introduction; 2 Osteoporosis; 3 Bone Remodeling; 4 Drug Therapy/Treatment of Osteoporosis; 4.1 Hormone-Replacement Therapies; 4.2 Bisphosphonates; 4.3 New Therapies for Osteoporosis.
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2017
• Extent: 1 online resource
• Subjects: 660.6; 570; Life sciences; Marine biotechnology; SCIENCE -- Chemistry -- Industrial & Technical; TECHNOLOGY & ENGINEERING -- Chemical & Biochemical; Marine biotechnology; Life Sciences; Animal Biochemistry; Cell Biology; Pharmacology/Toxicology; Biotechnology; Molecular Medicine; Animal Genetics and Genomics; Science -- Life Sciences -- Biology -- Molecular Biology; Medical -- Pharmacology; Science -- Biotechnology; Science -- Life Sciences -- Zoology -- General; Cellular biology (cytology); Pharmacology; Biotechnology; Medical research; Animal reproduction; Biochemistry; Cytology; Toxicology; Biotechnology; Medicine; Animal genetics; Science -- Life Sciences -- Biochemistry; Zoology & animal sciences; Electronic books; Electronic book
• Languages: English
• ISBNs: 9783319512846; 3319512846
• Related ISBNs: 9783319512822; 331951282X
• Notes: Note: Includes bibliographical references at the end of each chapters.; Note: Online resource; title from PDF title page (SpringerLink, viewed March 6, 2017).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.