Lipidomics of stem cells. (2017)

• Record Type: Book
• Further Information: Note: Alice Pébay, Raymond C.B. Wong, editors.
• Editors: Pébay, Alice; Wong, Raymond C. B
• Contents: Preface; Contents; Contributors; Chapter 1: Lysophosphatidic Acid and€Sphingosine- 1-ƯPhosphate in€Pluripotent Stem Cells; 1.1 Introduction; 1.2 Lipid Homeostasis in€Stem Cell Biology; 1.3 LPA and€S1P Synthesis and€Degradation; 1.3.1 LPA; 1.3.2 S1P; 1.4 LPA and€S1P Signaling; 1.5 Role of€LPA and€S1P in€Pluripotent Stem Cells; 1.6 Discussion and€Conclusion; References; Chapter 2: Morphogenetic Sphingolipids in€Stem Cell Differentiation and€Embryo Development; 2.1 Ceramide and€Its Derivatives; 2.1.1 Ceramide and€Ceramide-Enriched Compartments; 2.1.1.1 Ceramide and€Cilia. 2.1.1.2 Ceramide and€Exosomes2.1.2 Sphingosine-1-Phosphate; 2.1.3 Ceramide-1-Phosphate; 2.1.4 Glycosphingolipids; 2.1.5 Sphingolipids in€Stem Cell Therapy and€Regenerative Medicine; 2.2 Other Lipids; 2.3 Concluding Remarks; References; Chapter 3: Autotaxin in€Stem Cell Biology and€Neurodevelopment; 3.1 Introduction; 3.2 A Historical Perspective; 3.3 Structure and€Functional Domains; 3.4 Functional Roles in€Stem Cell Biology; 3.4.1 Embryonic Stem Cells; 3.4.2 Tissue-Specific Stem Cells; 3.4.3 Cancer Stem Cells; 3.5 Functional Roles in€Neurodevelopment; 3.5.1 Neural Stem Cells and€Neurogenesis. 3.5.2 Oligodendrogenesis3.6 Conclusion; References; Chapter 4: Lysophosphatidic Acid (LPA) Signaling in€Neurogenesis; 4.1 Introduction; 4.2 LPA Structure, Distribution, and€Metabolism; 4.2.1 Structure; 4.2.2 Distribution; 4.2.3 Metabolism; 4.2.4 Catabolism; 4.3 Lysophosphatidic Acid Receptor Signaling and€Downstream Pathways; 4.3.1 LPA1; 4.3.2 LPA2; 4.3.3 LPA3; 4.3.4 LPA4; 4.3.5 LPA5; 4.3.6 LPA6; 4.4 Lysophosphatidic Acid Signaling in€Embryonic Corticogenesis and€Neurodevelopmental Disease; 4.4.1 Fetal Corticogenesis; 4.4.2 LPA Is a€Potent Neuromodulator. 4.4.3 LPA in€Mitogenesis and€Neurogenesis4.4.4 LPA in€NPC Survival and€Programmed Cell Death; 4.4.5 LPA and€NPC Migration; 4.5 LPA Signaling and€Neurodevelopmental Diseases; 4.5.1 Hypoxic Injury; 4.5.2 Schizophrenia; 4.5.3 Hemorrhagic Injury and€Hydrocephalus; 4.6 Conclusion; References; Chapter 5: Fate Through Fat: Neutral Lipids as€Regulators of€Neural Stem Cells; 5.1 Neural Stem Cells and€Adult Neurogenesis; 5.1.1 NSC Niches: Form and€Function; 5.1.1.1 Subventricular Zone; 5.1.1.2 Dentate Gyrus; 5.1.2 Heterogeneity Within the€NSC Continuum; 5.1.3 Human Neurogenesis. 5.2 Neutral Lipid Metabolism in€the€Adult Brain5.2.1 Fatty Acids; 5.2.2 Triacylglycerides; 5.2.3 Lipid Droplets; 5.2.4 Apolipoproteins; 5.3 Neutral Lipids Are Physiological Regulators of€Adult€NSCs; 5.3.1 Neutral Lipid Carriers Are Required for€NSC Maintenance and€Neurogenesis; 5.3.1.1 FABPs; 5.3.1.2 ApoE; 5.3.2 Fatty Acid Metabolism Is Required for€Proliferation of€NSCs; 5.3.3 Distinct Effects of€Fatty Acid Classes on€NSCs and€Neurogenesis; 5.3.3.1 Polyunsaturated Fatty Acids (PUFAs); 5.3.3.2 Saturated Fatty Acids (SFAs); 5.3.3.3 Monounsaturated Fatty Acids (MUFAs).
• Publisher Details: Cham, Switzerland : Humana Press
• Publication Date: 2017
• Extent: 1 online resource (xiii, 212 pages), illustrations (some color)
• Subjects: 572/.57; Life sciences; Lipids; Stem cells; SCIENCE -- Life Sciences -- Biochemistry; Lipids; Stem cells; Science -- Life Sciences -- Cytology; Lipids; Cellular biology (cytology); Cell physiology; Cell membranes; Genetics (non-medical); Electronic books
• Languages: English
• ISBNs: 9783319493435; 3319493434
• Related ISBNs: 9783319493428; 3319493426
• Notes: Note: Online resource; title from PDF title page (SpringerLink, viewed March 6, 2017).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.