Zinc enzyme inhibitors : enzymes from microorganisms /: enzymes from microorganisms. (2016)
- Record Type:
- Book
- Title:
- Zinc enzyme inhibitors : enzymes from microorganisms /: enzymes from microorganisms. (2016)
- Main Title:
- Zinc enzyme inhibitors : enzymes from microorganisms
- Further Information:
- Note: Claudiu T. Supuran, Clemente Capasso, editors ; with contributions by E.A. Ambrose [and more].
- Other Names:
- Supuran, Claudiu T, 1962-
Capasso, Clemente - Contents:
- Preface; Contents; An Elusive Task: A Clinically Useful Inhibitor of Metallo-beta-Lactamases; 1 beta-Lactams and Mechanisms of Resistance; 2 MBLs Classification; 3 Structural Diversity in MBLs; 4 Substrate Binding and Catalytic Mechanism; 5 MBLs Inhibition; 5.1 Screening Methods; 5.2 Biphenyl Tetrazoles; 5.3 Pyrrole Derivatives; 5.4 Dicarboxylic Acid Derivatives; 5.5 Thiol Compounds; 5.5.1 Captopril; 5.6 Irreversible Inhibitors; 5.7 Thioester-Based Compounds; 5.8 Sulfonyl Compounds; 5.9 Natural Products; 5.10 Metal Chelators; 5.11 beta-Lactam-Derived Inhibitors. 5.12 Hydroxamic Acid Derivatives5.13 Sulfonamide Derivatives; 5.14 Rhodanine Derivatives; 5.15 Thioacetamide Derivatives; 5.16 Peptides; 6 Perspectives; References; Inhibitors of Histidinol Dehydrogenase; 1 Introduction; 2 HDH in Bacteria; 3 HDH Crystallographic Studies: Modeling; 4 HDH Inhibitors; 5 Applications: HDH as Therapeutic Target for the Development of Anti-infectious Compounds; 6 Conclusion: Future Prospects; References; Botulinum Neurotoxin, Tetanus Toxin, and Anthrax Lethal Factor Countermeasures; 1 Introduction; 2 Botulinum Neurotoxin Inhibitors; 3 Tetanus Toxin Countermeasures. 4 Anthrax Toxin Lethal Factor InhibitorsReferences; Inhibition and Activity Regulation of Bacterial Collagenases; 1 Introduction; 2 Bacterial Collagenases and Their Role in Disease; 3 Catalytic Class of Bacterial Collagenases; 4 Domain Architecture of Bacterial Collagenases; 5 Substrate Specificity of Clostridial Collagenases; 6Preface; Contents; An Elusive Task: A Clinically Useful Inhibitor of Metallo-beta-Lactamases; 1 beta-Lactams and Mechanisms of Resistance; 2 MBLs Classification; 3 Structural Diversity in MBLs; 4 Substrate Binding and Catalytic Mechanism; 5 MBLs Inhibition; 5.1 Screening Methods; 5.2 Biphenyl Tetrazoles; 5.3 Pyrrole Derivatives; 5.4 Dicarboxylic Acid Derivatives; 5.5 Thiol Compounds; 5.5.1 Captopril; 5.6 Irreversible Inhibitors; 5.7 Thioester-Based Compounds; 5.8 Sulfonyl Compounds; 5.9 Natural Products; 5.10 Metal Chelators; 5.11 beta-Lactam-Derived Inhibitors. 5.12 Hydroxamic Acid Derivatives5.13 Sulfonamide Derivatives; 5.14 Rhodanine Derivatives; 5.15 Thioacetamide Derivatives; 5.16 Peptides; 6 Perspectives; References; Inhibitors of Histidinol Dehydrogenase; 1 Introduction; 2 HDH in Bacteria; 3 HDH Crystallographic Studies: Modeling; 4 HDH Inhibitors; 5 Applications: HDH as Therapeutic Target for the Development of Anti-infectious Compounds; 6 Conclusion: Future Prospects; References; Botulinum Neurotoxin, Tetanus Toxin, and Anthrax Lethal Factor Countermeasures; 1 Introduction; 2 Botulinum Neurotoxin Inhibitors; 3 Tetanus Toxin Countermeasures. 4 Anthrax Toxin Lethal Factor InhibitorsReferences; Inhibition and Activity Regulation of Bacterial Collagenases; 1 Introduction; 2 Bacterial Collagenases and Their Role in Disease; 3 Catalytic Class of Bacterial Collagenases; 4 Domain Architecture of Bacterial Collagenases; 5 Substrate Specificity of Clostridial Collagenases; 6 Inhibitors Are Substrate Mimetics; 7 The Active Site of Clostridial Collagenases; 8 Exosites; 9 Conclusion; References; Fungal Carbonic Anhydrases and Their Inhibition; 1 Introduction; 2 Fungal Carbonic Anhydrases. 3 Inhibition of Carbonic Anhydrase Nce103p from Saccharomyces cerevisiae4 Inhibition of Can2 from the Pathogenic Basidiomycete Cryptococcus neoformans; 5 Inhibition of beta-CAs from the Ascomycetous Yeasts: Candida albicans and Candida glabrata; 6 Inhibition of the Carbonic Anhydrases MgCA from the Dermatophytic Yeast Malasseziaglobosa; 7 Inhibition of CAS1 and CAS2 of the Non-Pathogenic Filamentous Ascomycete Sordaria macrospora; 8 Conclusion; References; Protozoan Carbonic Anhydrases; 1 Introduction; 2 Carbonic Anhydrases; 3 CA Inhibitors; 3.1 Anions; 3.2 Sulfonamides; 3.3 Dithiocarbamates. 4 Protozoan CAs of Therapeutic Interest4.1 Malaria; 4.1.1 Plasmodia CAs: Identification of a New Class of CAs, the eta-CA; 4.1.2 eta-CA Zinc Coordination Pattern; 4.1.3 eta-CA Kinetic Constants; 4.1.4 eta-CA Inhibition Studies; 4.1.5 Role of CA in P. falciparum; 4.2 Leishmaniasis; 4.2.1 Leishmania CAs; 4.2.2 LdcCA Primary Structure; 4.2.3 LdcCA Kinetic Constants; 4.2.4 LdcCA Inhibition Studies; 4.2.5 Role of CA in Leishmania; 4.3 American Trypanosomiasis (Chagas Disease); 4.3.1 Trypanosoma CA; 4.3.2 TcCA Primary Structure Analysis; 4.3.3 TcCA Kinetic Constants; 4.3.4 TcCA Inhibition Studies. … (more)
- Publisher Details:
- Cham, Switzerland : Springer
- Publication Date:
- 2016
- Copyright Date:
- 2017
- Extent:
- 1 online resource
- Subjects:
- 615.3/5
Chemistry
Zinc enzymes -- Inhibitors
MEDICAL -- Pharmacology
Science -- Life Sciences -- Biochemistry
Medical -- Pharmacy
Enzymology
Pharmaceutical technology
Biochemistry
Enzymes
Pharmaceutical technology
Science -- Chemistry -- Clinical
Biochemistry
Electronic books - Languages:
- English
- ISBNs:
- 9783319461120
3319461125 - Related ISBNs:
- 3319461117
9783319461113 - Access Rights:
- Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
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- Physical Locations:
- British Library HMNTS - ELD.DS.373294
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