Molecular and cellular biology of platelet formation : implications in health and disease /: implications in health and disease. ([2016])

• Record Type: Book
• Further Information: Note: Harald Schulze, Joseph Italiano, editors.
• Editors: Schulze, Harald; Italiano, Joseph
• Contents: Preface; Contents; Part I: Megakaryocytes and Thrombopoiesis; 1: Megakaryopoiesis and Platelet Biogenesis; 1.1 Introduction; 1.2 Megakaryocyte Development; 1.2.1 Commitment to the Megakaryocyte Lineage; 1.2.2 Polyploidization; 1.2.3 Cytoplasmic Maturation; 1.3 Platelet Formation; 1.3.1 The Proplatelet Theory; 1.3.2 Morphogenesis of Proplatelets; 1.3.3 The Cytoskeletal Engine of Platelet Biogenesis; 1.3.3.1 Microtubules Power Proplatelet Extension; 1.3.3.2 Transport of Organelles and Granules Along Proplatelets into Assembling Platelets. 1.3.3.3 Actin-Driven Bending and Branching of Proplatelets1.3.3.4 The Spectrin Membrane Skeleton; 1.3.4 Release of Individual Platelets; References; 2: Transcriptional Regulation of Platelet Formation: Harnessing the Complexity for Efficient Platelet Production In Vitro; 2.1 Introduction; 2.2 Haematopoietic Stem Cell Differentiation: About Heterogeneity, Stochastic and Directed Fate Decisions; 2.3 Regulation of Gene Expression: Multilayer Complexity; 2.4 Making Platelets: The Megakaryocyte, Its Niche and Its DNA Content; 2.4.1 MK Specification and Differentiation. 2.4.2 Triggers for Proplatelet Formation and Platelet Release: The Little Bit We Do Know2.4.3 MK DNA Content: Does Ploidy Really Matter?; 2.5 Transcription Factors Controlling the Megakaryocyte Cell Fate; 2.5.1 The GATAs; 2.5.1.1 GATA1 and GATA2; 2.5.1.2 FOG1 and Other Partners of GATA1; 2.5.1.3 Down Syndrome and Megakaryopoiesis; 2.5.2 TAL1; 2.5.3 RUNX1; 2.5.3.1 RUNX1 and Haematopoiesis; 2.5.3.2 Familial Platelet Disorder/AML; 2.5.3.3 RUNX1 in Partnership; 2.5.4 ETS Factors; 2.5.4.1 FLI1; 2.5.4.2 ERG; 2.5.4.3 ETV6; 2.5.5 EVI1; 2.5.6 NFE2 and Related Transcription Factors. 2.5.6.1 NFE22.5.6.2 BACH1 and BACH2; 2.5.7 SRF and MKL1; 2.5.8 NFAT; 2.5.9 MEIS1 and Its Regulator GFI1B; 2.5.10 MYB; 2.5.11 It Is All About Networking; 2.6 Gene Regulation: A Gateway into New Biological Discoveries; 2.7 Transcription Factors and the "Making" of Platelets for Clinical Use; 2.7.1 The Clinical Need for Platelets Produced in the Laboratory; 2.7.2 Harvesting Platelets from In Vitro-Produced MKs; 2.7.3 Developmental Differences in Megakaryocytes and Platelets: Embryos Are Not Adults; 2.7.4 MKs and Platelets from Human Pluripotent Stem Cells; 2.7.5 Disease Modelling. 2.8 Concluding RemarksReferences; 3: Megakaryocytic Transcription Factors in Disease and Leukemia; 3.1 Introduction; 3.2 Specific Transcription Factors; 3.2.1 GATA Family Transcription Factors; 3.2.1.1 GATA-1; 3.2.1.2 GATA-2; 3.2.1.3 ZFPM1 (Previously Called Friend of GATA-1 (FOG1)); 3.2.1.4 GATA Factor Mutations in Human Congenital Thrombocytopenias; 3.2.1.5 GATA-1 Mutations in Down Syndrome Transient Myeloproliferative Disorder and Acute Megakaryoblastic Leukemia; 3.2.1.6 GATA-2 Mutations in Familial Myelodysplastic Syndrome and Acute Myelogenous Leukemia.
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2016
• Copyright Date: 2016
• Extent: 1 online resource, illustrations
• Subjects: 612.1/17; Medicine; Blood platelets; MEDICAL -- Physiology; SCIENCE -- Life Sciences -- Human Anatomy & Physiology; Blood platelets; Biomedicine; Human Physiology; Hematology; Cell Biology; Gene Therapy; Molecular Medicine; Blood Transfusion Medicine; Blood Platelets; Medical -- Hematology; Science -- Life Sciences -- Biology -- Molecular Biology; Medical -- Genetics; Haematology; Cellular biology (cytology); Medical genetics; Medical research; Human physiology; Hematology; Cytology; Gene therapy; Blood transfusion; Physiology; Electronic books
• Languages: English
• ISBNs: 9783319395623; 3319395629
• Related ISBNs: 9783319395609; 3319395602
• Notes: Note: Includes bibliographical references.; Note: Online resource; title from PDF title page (EBSCO, viewed February 18, 2017).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.