The Hsp60 chaperonin. (2015)

• Record Type: Book
• Further Information: Note: Peter Bross.
• Authors: Bross, Peter
• Contents: Introduction.- Historical sketch of the discovery and recognition of the function of chaperonins.- Molecular structure of chaperonins.- Folding by enclosure in the chaperonin cavity.- Evolutionary origins and family relations.- Chaperoning mechanisms: folding helpers, folding protectors or misfolding blockers?.- Sequence variations in proteins affecting chaperonin dependence.- Genetic organization of type I chaperonin genes.- Regulation of type I chaperonin gene expression.- Subcellular localization.- Posttranslational modifications.- Variations in Hsp60 and Hsp10 in humans.- Type I chaperonins are essential for cell viability and mutations cause deficiency phenotypes.- Human diseases caused by genetic mutations in the Hsp60/Hsp10 system.- Molecular investigations of disease mechanisms.- Molecular investigations of disease mechanisms.- Outlook.
• Publisher Details: Cham : Springer
• Publication Date: 2015
• Copyright Date: 2015
• Extent: 1 online resource (85 pages)
• Subjects: 572.6; Life sciences; Heat shock proteins; Molecular chaperones; Science -- Chemistry -- Organic; Science -- Life Sciences -- Biology -- Molecular Biology; Biochemistry; Medical research; Biochemistry; Bioorganic chemistry; Medicine; Science -- Life Sciences -- Biochemistry; Proteins
• Languages: English
• ISBNs: 9783319260884
• Related ISBNs: 9783319260860
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.