Systems biology of tumor physiology : rethinking the past, defining the future /: rethinking the past, defining the future. ([2016])

• Record Type: Book
• Further Information: Note: David H. Nguyen.
• Authors: Nguyen, David H
• Contents: Dedication; Abstract; Preface; Contents; Author Biography; Chapter 1: Macrophages, Extracellular Matrix, and Estrogens in Breast Cancer Risk; Introduction; Section 1: Estrus Cycle Regulates Macrophages in the Mammary Gland; Section 2: The Estrus Cycle Regulates Macrophages in the Ovaries; Section 3: The Effects of Estrogens on Macrophages; Section 4: Macrophages as Targets of Endocrine Disrupting Chemicals; Section 5: Estrogen Effects on Macrophage ROS Production; Section 6: Complex Interplay Between Macrophages and the Extracellular Matrix; Composition of the Extracellular Matrix. Macrophages Modify the Mammary Extracellular Matrix Effect of Increased Matrix Stiffness on Breast Cancer Progression; Effect of Increased Matrix Stiffness on Macrophage Phenotypes; Section 7: Testing the Estrus-Regulated Macrophage-­Dependent Hypothesis of Breast Cancer Risk; Directly and Indirectly Testing the Hypothesis; Experimental Approaches to Directly Testing the Hypothesis; Indirectly Testing the Hypothesis by Making Verifiable Predictions; The Effect of Aging; The Effect of Premature Ovarian Failure; The Effect of Hormone Replacement Therapy in Post-menopausal Women. The Effect of Wiskott-Aldrich Syndrome on Breast Density Closing Thoughts; References; Chapter 2: Cellular Plasticity, Cancer Stem Cells, and Cells-of-Origin; Introduction; Section 1: Defining the Terminology Necessary for Understanding This Field; Stem Cell; Progenitor Cell; Differentiation; Potency; Lineage Commitment; Transdifferentiation; Dedifferentiation; Plasticity; Epithelial-to-Mesenchymal Transition (EMT); Niche; Microenvironment; Clonality; Cancer Stem Cell; Cell-of-Origin; Section 2: Confusion Among Stem Cell, Cancer Stem Cell, and Cell-of-Origin Concepts. Section 3: Evidence for the Theory of Cell-of-Origin as the Root of Tumors Section 4: Evidence for the Theory of Cellular Plasticity in Tumor Development; Section 5: Confounding Factors in the Plasticity Versus Cell-Ưof-ƯOrigin Debate; Cell Fusion; Induced Mesenchymal States; References; Chapter 3: Using Mouse Models and Making Sense of Them; Introduction; Section 1: Selecting the Right Model; The Age of the Mice; Appreciate the Estrus Cycle to Reduce Variation in Data; The Estrus Cycle Affects the Immune System; Identifying Estrus Stage; Daily Estrus Staging Can Cause Pseudopregnancy. Background Genetics Developmental Deformities Give Insight into Future Phenotypes; The Composition of Mouse Chow; Section 2: Correctly Using the Right Model; Mock Procedures for Control Groups Yield Cleaner and More Consistent Data; Different Types of Stressors; Environmental Enrichment and Cancer; Time of Day for Treatments and Exposures; The Confounding Effects of Anesthesia; Examples of Rodent Anesthetics; Completely Thaw Frozen Plasma and Re-Suspend for Cleaner Data; Section 3: Making Sense of the Data; Collect the Endocrine and Other Organs for Retrospective Analysis; The Thymus.
• Publisher Details: Cham : Springer
• Publication Date: 2016
• Copyright Date: 2016
• Extent: 1 online resource
• Subjects: 616.99/407; Medicine; Cancer -- Pathophysiology; HEALTH & FITNESS -- Diseases -- General; MEDICAL -- Clinical Medicine; MEDICAL -- Diseases; MEDICAL -- Evidence-Based Medicine; MEDICAL -- Internal Medicine; Cancer -- Pathophysiology; Neoplasms -- physiopathology; Science -- Life Sciences -- General; Science -- Life Sciences -- Cytology; Life sciences: general issues; Cellular biology (cytology); Oncology; Biological models; Cell physiology; Medical -- Oncology; Oncology; Electronic books
• Languages: English
• ISBNs: 9783319256016; 3319256017; 3319255991; 9783319255996
• Related ISBNs: 9783319255996
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (EBSCO, viewed December 16, 2015).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.