Studies on experimental toxicology and pharmacology. (2015)

• Record Type: Book
• Further Information: Note: Stephen M. Roberts, James P. Kehrer and Lars-Oliver Klotz, editors.
• Editors: Roberts, Stephen M; Kehrer, James P; Klotz, Lars-Oliver
• Contents: Contributors; Biographies of Editors; Part I: Toxicological Mechanisms and Evaluation of Oxidative Stress; Chapter 1: A Historical Perspective on Oxidative Stress and Intracellular Redox Control; 1.1 Introduction; 1.2 The Search for the Grandmaster; 1.3 The Pre-paradigm Era; 1.4 The 1980s and the Emergence of More General Concepts; 1.5 Puzzle Solving; 1.6 Clouds on the Horizon; 1.7 The Journey to the Cysteine Chapel; 1.8 The Rise, Demise and Renaissance of the Antioxidant; 1.9 Conclusions; References; Chapter 2: An Overview of Free Radicals as Causes and Consequences of Toxicity. 2.1 Introduction2.2 Radical Chemistry; 2.3 Characteristic Oxidative Reactions; 2.3.1 Proteins and Peptides; 2.3.2 Lipids; 2.3.3 DNA; 2.3.4 Apoptosis; 2.3.5 Role of Metal Ions; 2.4 Summary; References; Chapter 3: Oxidants, Radicals, Free Radicals, and Other Bad Stuff in Mechanisms of Toxicity; 3.1 Free Radicals and Reactivity; 3.2 It Is Well-Known That; 3.3 Conclusions; References; Chapter 4: Lipid Oxidation; 4.1 Introduction; 4.2 Types of Lipid Oxidation; 4.2.1 Enzymatic Oxidation of Lipids; 4.2.2 Non-enzymatic Oxidation of Lipids; 4.3 Reactivity of Lipid Oxidation Products. 4.4 Types of Biological Effects4.4.1 Effects on Cell Membranes; 4.4.2 Toxicity; 4.4.3 Pro-inflammatory or Deleterious Effects; 4.4.4 Cytoprotective Effects; 4.5 Mechanisms of Biological Effects: Interactions with Receptors and Signalling Pathways; 4.6 Metabolism; 4.7 Effects of Other Lipid Modifications; 4.8 Analysis of Lipid Oxidation; 4.9 Oxidized Lipids and Therapeutics; 4.10 Summary and Perspectives; References; Chapter 5: Protein Oxidation in Toxicology; 5.1 Introduction; 5.2 Oxidative Stress and Protein Oxidation; 5.3 The Chemistry of Protein Oxidation; 5.3.1 Backbone Damage. 5.3.2 Side-Chain Damage5.3.2.1 Aliphatic Amino Acid Residues; 5.3.2.2 Aromatic Amino Acid Residues; 5.3.2.3 Sulfur-Containing Amino Acid Residues; 5.3.2.4 Carbonyl Group Formation; 5.4 Consequences of Protein Oxidation; 5.5 Repair and Degradation of Oxidatively Damaged Proteins; 5.5.1 Repair Systems; 5.5.1.1 Repair of Disulfides; 5.5.1.2 Repair of Methionine Sulfoxides; 5.5.2 Degradation Systems; 5.5.2.1 The Proteasomal System; 5.5.2.2 The Lysosomal System; 5.6 Reactive Species and Protein Oxidation: Roles in Toxicology; 5.6.1 Toxins Might Be Reactive Species. 5.6.2 Toxins Are Metabolized to Reactive Species5.6.3 Reactive Species Are Generated in Redox Cycling of Toxins; 5.6.4 Toxins Interfere with the Antioxidant Defense System; 5.6.5 Toxins Increase the Endogenous RS generation; 5.6.5.1 Mitochondrial Electron Transport Chain; 5.6.5.2 Cytochrom P450 System; 5.6.6 Toxins Provoking the Immune Response; 5.7 Conclusion; References; Chapter 6: Oxidative Stress and DNA Damage Association with Carcinogenesis: A Truth or a Myth?; 6.1 Introduction; 6.2 Toxic Forms of Oxygen and Primary Reactions; 6.3 Types of Oxidative DNA Damage; 6.3.1 Base Damage.
• Publisher Details: Cham : Humana Press
• Publication Date: 2015
• Extent: 1 online resource
• Subjects: 615.9; Life sciences; Toxicology; Pharmacology; MEDICAL -- Pharmacology; Pharmacology; Toxicology; Toxicology; Science -- Life Sciences -- Cytology; Medical -- Public Health; Pharmacology; Cellular biology (cytology); Environmental medicine; Cytology; Environmental Medicine; Electronic books
• Languages: English
• ISBNs: 9783319190969; 3319190962
• Related ISBNs: 9783319190952; 3319190954; 9783319190952
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from PDF title page (EBSCO, viewed October 5, 2015).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.