Drug-Induced Liver Toxicity. (2018)

• Record Type: Book
• Further Information: Note: Minjun Chen, Yvonne Will.
• Editors: Chen, Minjun; Will, Yvonne
• Contents: Part I: Introduction 1. Overview of Mechanisms of Drug-Induced Liver Injury (DILI) and Key Challenges in DILI Research Nabil Noureddin and Neil Kaplowitz Part II: In Silico and Modeling Approaches 2. Detection, Elimination, Mitigation, and Prediction of Drug-Induced Liver Injury in Drug Discovery Francois Pognan 3. Drug-Induced Liver Injury (DILI) Classification and Its Application on Human DILI Risk Prediction Shraddha Thakkar, Minjun Chen, Huixiao Hong, Zhichao Liu, Hong Fang, and Weida Tong 4. Physicochemical Properties and Structural Alerts Lilia Fisk, Nigel Greene, and Russ Naven 5. Quantitative Structure-Activity Relationship Models for Predicting Risk of Drug-Induced Liver Injury in Humans Huixiao Hong, Jieqiang Zhu, Minjun Chen, Ping Gong, Chaoyang Zhang, and Weida Tong 6. An Introduction to DILIsym® Software, a Mechanistic Mathematical Representation of Drug-Induced Liver Injury Christina Battista, Brett A. Howell, Scott Q. Siler, and Paul B. Watkins Part III: In Vitro Technologies 7. Prediction of Human Liver Toxicity Using In Vitro Assays: Limitations and Opportunities Franck A. Atienzar and Jean-Marie Nicolas 8. Use of Liver-Derived Cell Lines for the Study of Drug-Induced Liver Injury Zhen Ren, Si Chen, Baitang Ning, and Lei Guo 9. Evaluation of Drug-induced Liver Injuries (DILI) with Human Hepatocytes: Scientific Rationale and Experimental Approaches Albert P. Li 10. Status and Use of Induced Pluripotent Stem Cells (iPSCs) in Toxicity Testing Min Wei Wong, Chris S. Pridgeon, Constanze Schlott, B. Kevin Park, and Christopher E.P. Goldring 11. Engineered Human Liver Co-Cultures for Investigating Drug-Induced Liver Injury Chase P. Monckton, and Salman R. Khetani 12. Status and Future of 3D Cell Culture in Toxicity Testing Monicah A. Otieno, Jinping Gan, and William Proctor 13. Reactive Metabolite Assessment in Drug Discovery and Development in Support of Safe Drug Design Axel Pähler 14. In Vitro Assessment of Mitochondrial Toxicity to Predict Drug-Induced Liver Injury Mathieu Porceddu, Nelly Buron, Pierre Rustin, Bernard Fromenty, and Annie Borgne-Sanchez 15. Bile Salt Export Pump: Drug-Induced Liver Injury and Assessment Approaches Ruitang Deng 16. High Content Screening for Prediction of Human Drug-Induced Liver Injury Mikael Persson 17. Interpretation, Integration, and Implementation of In Vitro Assay Data: The Predictive Toxicity Challenge Deborah S. Light, Michael D. Aleo, and J. Gerry Kenna Part IV: Methodologies Applied in Regulatory Science 18. Perspectives on the Regulatory and Clinical Science of Drug-Induced Liver Injury (DILI) Mark I. Avigan and Monica A. Muñoz 19. Regulatory Toxicological Studies: Identifying Drug-Induced Liver Injury Using Nonclinical Studies Elizabeth Hausner and Imran Khan 20. Hy's Law and eDISH for Clinical Studies John Senior and Ted Guo 21. Variability in Baseline Liver Test Values in Clinical Trials: Challenges in Enhancing Drug-Induced Liver Injury Assessment in Subjects with Liver Disease Bereket Tesfaldet, Gyorgy Csako, Tejas Patel, Md Shamsuzzaman, and Eileen Navarro Almario 22. Postmarketing Surveillance of Drug-Induced Liver Injury S. Christopher Jones, Cindy Kortepeter, and Allen D. Brinker Part V: Methodologies for Clinical Studies 23. Host Risk Modifiers in Idiosyncratic Drug-Induced Liver Injury (DILI) and Its Interplay with Drug Properties Camilla Stephens, M. Isabel Lucena, and Raúl J. Andrade 24. Human Leukocyte Antigen (HLA) and Other Genetic Risk Factors in Drug-Induced Liver Injury (DILI) Ann K. Daly 25. Immune Mechanisms in Drug-Induced Liver Injury Hartmut Jaeschke and Dean J. Naisbitt 26. Translational and Mechanistic Biomarkers of Drug-Induced Liver Injury Daniel J. Antoine 27. Causality Assessment Methods in Drug-Induced Liver Injury Rolf Teschke and Gaby Danan Part VI: New Emerging Technologies 28. Circulating MicroRNAs as Novel Biomarkers of Drug-Induced Liver Injury in Humans Julian Krauskopf, Jos C. Kleinjans, and Theo M. de Kok 29. Systems Microscopy Approaches in Unraveling and Predicting Drug-Induced Liver Injury (DILI) Marije Niemeijer, Steven Hiemstra, Steven Wink, Wouter den Hollander, Bas ter Braak, and Bob van de Water 30. Non-Invasive Pre-Clinical and Clinical Imaging of Liver Transporter Function Relevant to Drug-Induced Liver Injury J. Gerry Kenna, John C. Waterton, Andreas Baudy, Aleksandra Galetin, Catherine D.G. Hines, Paul Hockings, Manishkumar Patel, Daniel Scotcher, Steven Sourbron, Sabina Ziemian, and Gunnar Schuetz.
• Publisher Details: New York : Humana Press
• Publication Date: 2018
• Copyright Date: 2018
• Extent: 1 online resource (667 pages)
• Subjects: Medicine; Toxicology; Medical -- Pharmacology; Pharmacology
• Languages: English
• ISBNs: 9781493976775
• Related ISBNs: 9781493976768
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.