Endocytosis and signaling. ([2018])

• Record Type: Book
• Further Information: Note: Christophe Lamaze, Ian Prior, editors.
• Editors: Lamaze, Christophe; Prior, Ian
• Contents: Intro; Preface; Contents; 1 The Endosomal Network: Mediators andRegulators ofEndosome Maturation; 1.1 Endosome Maturation Overview; 1.2 Endosome Functions; 1.3 Mediators ofEndosome Maturation; 1.3.1 Phosphoinositides; 1.3.2 Rab GTPases; 1.3.3 Tethers; 1.3.4 ESCRTs; 1.3.5 V-ATPase; 1.3.6 Additional Mediators ofVacuolar pH; 1.3.7 Cytoskeleton; 1.4 Coordination ofEndosome Maturation; 1.4.1 Sorting Compartments; 1.4.2 Rab Conversion; 1.4.3 Rab5 Regulation; 1.4.4 Rab7 Regulation; 1.4.5 PIP Conversion; 1.4.6 PIP Regulation; 1.4.7 V-ATPase Regulation. 1.5 Contributions ofOther Organelles toEndosome Maturation1.5.1 ER; 1.5.2 Lipid Droplets; 1.5.3 Cross talk withtheAutophagy Pathway; 1.6 Perturbations ofEndosome Maturation inDisease; 1.7 Conclusions; References; 2 Integration oftheEndocytic System intotheNetwork ofCellular Functions; 2.1 Introduction; 2.2 Cross Talk Between theEndosomal System andOther Organelles; 2.2.1 Endosomal-ER Contact Sites Regulate Multiple Cellular Processes; 2.2.2 Endolysosomal-Mitochondrial Interactions Are Mediated byVarious Mechanisms. 2.2.3 Endosomal ESCRT Machinery Maintains Integrity ofthePM andNuclear Envelope2.3 The Role ofEndosomes inRegulation ofMetabolic Pathways; 2.3.1 Involvement oftheEndocytic System inVesicular Trafficking ofGLUT4; 2.3.2 The Endolysosomal Pathway Mediates Intracellular Cholesterol Transfer; 2.3.3 Interplay Between theEndocytic System andAutophagy; 2.4 Conclusions; References; 3 GTPases Rac1 andRas Signaling fromEndosomes; 3.1 Introduction; 3.1.1 AnOverview oftheEndosomal System; 3.1.2 Endocytosis andSignaling fromEndosomal Compartments. 3.2 Signaling oftheSmall GTPases Ras andRac1 fromEndosomes3.2.1 Ras Signaling fromEndosomes; 3.2.2 Rac1 Signaling fromEndosomes; References; 4 ESCRT andMembrane Protein Ubiquitination; 4.1 Ubiquitination; 4.1.1 Ubiquitination ofMembrane Proteins; 4.1.2 Endocytosis-As Consequence ofUbiquitination; 4.2 Ubiquitin-Mediated Protein Sorting onEndosomes; 4.3 The ESCRT Complexes-Domains, Conformation andInteraction; 4.3.1 Deubiquitinating Enzymes andCo-factors onEndosomes; 4.4 Reverse Membrane Remodelling-Driven byESCRT-III andVps4; References.
• Publisher Details: Cham : Springer
• Publication Date: 2018
• Copyright Date: 2018
• Extent: 1 online resource, color illustrations
• Subjects: 571.6; Life sciences; Endocytosis; Cellular signal transduction; SCIENCE -- Life Sciences -- Anatomy & Physiology; Life Sciences; Membrane Biology; Cell Physiology; Cell Cycle Analysis; Protein Science; Cellular signal transduction; Endocytosis; Science -- Life Sciences -- Cytology; Science -- Life Sciences -- Biochemistry; Cellular biology (cytology); Proteins; Cell membranes; Cell physiology; Cell cycle; Biochemistry; Electronic books
• Languages: English
• ISBNs: 9783319967042; 3319967045
• Related ISBNs: 9783319967035; 3319967037
• Notes: Note: Includes bibliographical references.; Note: Online resource; title from PDF title page (EBSCO, viewed August 15, 2018).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.