Immune hematology : diagnosis and management of autoimmune cytopenias /: diagnosis and management of autoimmune cytopenias. (©2018)

• Record Type: Book
• Further Information: Note: Jenny M. Despotovic, editor.
• Other Names: Despotovic, Jenny M
• Contents: Intro; Preface; Contents; Contributors; Part I: Immune Thrombocytopenia (ITP); Chapter 1: Background of Immune Thrombocytopenia; Introduction; Historical Perspective; Terminology; Presentation; Primary ITP and Secondary ITP; Differential Diagnosis; Conclusion; References; Chapter 2: Pathophysiology of Immune Thrombocytopenia; Platelet Autoantibodies; Balance of Platelet Destruction and Production; Abnormal Megakaryocyte Morphology; Antibody Destruction of Megakaryocytes; Inadequate Thrombopoietin Levels; T Cell-Mediated ITP; T Cell-Propagated Autoantibody Production; Helper T Cell Responses. Role of Th17 CellsRegulatory T cells; B Cell-Mediated ITP; B-Regulatory Cells; Myeloid-Derived Suppressor Cells; Genetic Studies; Secondary ITP; Helicobacter pylori-Related ITP; CMV-Related ITP; Varicella Zoster-Related ITP; Hepatitis C-Related ITP; HIV-Related ITP; Malignancy-Related ITP; Other Autoimmune Disorders; Evans Syndrome; Autoimmune Lymphoproliferative Syndrome (ALPS); References; Chapter 3: Presentation and Evaluation of Immune Thrombocytopenia; Introduction; Clinical Presentation; History; Physical Examination; Bleeding Assessment; Initial Diagnostic Investigations. Diagnostic ApproachAdditional Testing for Suspected ITP; The Role of Bone Marrow Testing; Platelet Antibody Testing; Screening Tests for Associated Conditions; Infectious Triggers for ITP: Hepatitis C, HIV, and H. pylori; Autoimmune Conditions; Immunodeficiencies; Summary; References; Chapter 4: The Treatment of Immune Thrombocytopenia; Introduction; General Treatment Considerations; Who Should Be Treated?; First-Line Management; Corticosteroids; Mechanism of Action; Steroid Treatment Recommendations; Intravenous Immunoglobulin; Mechanism of Action; IVIG Treatment Recommendations. Anti-D ImmunoglobulinMechanism of Action; Anti-D Treatment Recommendations; Second-Line Therapy; Splenectomy; Mechanism of Action; Splenectomy Treatment Recommendations; Rituximab; Mechanism of Action; Rituximab Treatment Recommendations; Thrombopoietin Receptor Agonists (TPO-RAs); Mechanism of Action; TPO-RA Adverse Effects; Treatment Recommendations; Use of TPO-RAs in Pediatric ITP; Use of TPO-RAs in Newly Diagnosed ITP; Management of Life-Threatening Bleeding; Other Agents; Antimetabolites; Novel Therapies; References; Part II: Autoimmune Hemolytic Anemia (AIHA). Chapter 5: Background, Presentation and Pathophysiology of Autoimmune Hemolytic AnemiaHistory of Immune Hemolysis; Definitions and Classification; Warm AIHA; Pathophysiology; Clinical Features; Cold AIHA (Cold Agglutinin Disease); Pathophysiology; Clinical Features; Paroxysmal Cold Hemoglobinuria; Pathophysiology; Clinical Features; Mixed AIHA; References; Chapter 6: Treatment of Autoimmune Hemolytic Anemia; Introduction; Diagnosis and Classification; Etiology; Frontline Treatment; Blood Transfusions; Corticosteroids; Second-Line Treatments; Rituximab; Splenectomy; Immunosuppressive Therapies.
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2018
• Copyright Date: 2018
• Extent: 1 online resource, illustrations
• Subjects: 616.978; Medicine; Autoimmune diseases -- Diagnosis; Immunology; Hematology; MEDICAL -- Immunology; MEDICAL -- Hematology; HEALTH & FITNESS -- Diseases -- General; Autoimmune diseases -- Diagnosis; Hematology; Immunology; Oncology; Medical -- Oncology; Oncology; Oncology ; Haematology; Electronic books
• Languages: English
• ISBNs: 9783319732695; 3319732692
• Related ISBNs: 3319732684; 9783319732688
• Notes: Note: Includes bibliographical references and index.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.