Systems pharmacology and pharmacodynamics. (2016)

• Record Type: Book
• Further Information: Note: Donald E. Mager, Holly H.C. Kimko, editors.
• Other Names: Mager, Donald E; Kimko, Holly H. C
• Contents: Preface; Contents; Editors and Contributors; Systems Modeling; 1 Systems Pharmacology and Pharmacodynamics: An Introduction; Abstract; 1.1 Introduction; 1.2 Systems Theory in Biology and Pharmacokinetics; 1.2.1 Network-Based Pharmacology and Physiological Control Systems; 1.3 Pharmacodynamics; 1.3.1 Population-Based Pharmacology; 1.4 Systems Pharmacology Models; 1.5 Prospectus; References; 2 Role of Systems Modeling in Regulatory Drug Approval; Abstract; 2.1 Introduction; 2.2 Physiologically-Based Pharmacokinetic (PBPK) Modeling; 2.2.1 Drug-Drug and Gene-Drug Interactions. 2.2.2 Specific Populations2.3 Mechanism-Based Drug Safety Evaluation Using Systems Pharmacology; 2.3.1 Ontology of Adverse Events; 2.3.2 Databases-Leveraging "Precompetitive" Data; 2.3.3 Initial Test Cases: Cardiotoxicity and Hepatotoxicity; 2.4 Conclusion and Future Directions; References; 3 Quantitative Systems Pharmacology: Applications and Adoption in Drug Development; Abstract; 3.1 Introduction; 3.1.1 Industry Status and Needs; 3.1.2 Quantitative Systems Pharmacology in the Drug Development Context; 3.2 Application of QSP Across the R & D Pipeline. 3.2.1 Research and Preclinical Applications3.2.2 Translational Application; 3.2.3 Clinical Application; 3.3 Understanding and Back-Translation of Clinical Findings; 3.4 Safety and Toxicity Predictions and Understanding; 3.5 Mechanistic Disease Platforms; 3.5.1 Rheumatoid Arthritis; 3.5.2 Bone Remodeling; 3.6 Adoption of QSP in Industry; 3.7 Challenges, Considerations and Future Directions for QSP in Industry; References; 4 Systems Pharmacology: An Overview; Abstract; 4.1 Introduction; 4.2 Systems Pharmacology: A Network-Based View of Drug Action. 4.3 Systems Pharmacology: Relationships to Personalized and Precision Medicine4.4 Bioinformatics for Systems Pharmacology; 4.4.1 Pharmacogenomics; 4.4.2 Structural Reasoning in Systems Pharmacology; 4.4.2.1 Protein Structure Informs Network Biology; 4.4.2.2 Structural Considerations Guide Drug Discovery; 4.4.2.3 Genomic Variation Imposes Constraints on Networks Through Protein and Drug Structure; 4.5 Network Dynamics in Systems Pharmacology; 4.5.1 Fragile and Robust Nodes; 4.5.2 Sensitivity Analysis to Assess Fragility. 4.5.3 Sensitivity Analysis for Discovery of Targets for Combination Therapy4.6 Networks to Pharmacodynamics; 4.7 Systems-Based PK/PD Models; 4.8 Future of Systems Pharmacology; References; 5 Discrete Dynamic Modeling: A Network Approach for Systems Pharmacology; Abstract; 5.1 Introduction; 5.2 Methodology in Discrete Dynamic Modeling; 5.2.1 Constructing the Network; 5.2.2 Determining the Boolean Functions; 5.2.3 Selecting Time Implementation for State Transitions; 5.2.4 Evaluating the Dynamics and Steady-States of the System; 5.2.5 Network Reduction Techniques.
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2016
• Extent: 1 online resource
• Subjects: 615.1; Medicine; Pharmacology; Pharmacokinetics; Systems biology; Pharmacokinetics; Pharmacology; Systems Biology; Drug Approval; Drug Design; MEDICAL -- Pharmacology; Pharmacokinetics; Pharmacology; Systems biology; Mathematics -- Applied; Medical -- Biochemistry; Maths for scientists; Biochemistry; Pharmaceutical technology; Biochemistry; Medical -- Pharmacy; Pharmaceutical technology; Electronic books
• Languages: English
• ISBNs: 9783319445342; 3319445340
• Related ISBNs: 9783319445328; 3319445324
• Notes: Note: Includes bibliographical references and index.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.