Design and applications of nanoparticles in biomedical imaging. ([2017])

• Record Type: Book
• Further Information: Note: Jeff W.M. Bulte, Michel M.J. Modo, editors.
• Editors: Bulte, Jeff W. M; Modo, Michel Mathias Jeannot Joseph
• Contents: Preface; Contents; Nanoparticles as a Technology Platform for Biomedical Imaging; 1 Origins of Nanoparticles in Biomedical Imaging; 2 The Emergence of a Synergy Between Therapeutics and Imaging; 3 An Outlook on Challenges and Future Opportunities; References; Basic Principles of In Vivo Distribution, Toxicity, and Degradation of Prospective Inorganic Nanoparticles for Imaging; 1 General Introduction; 1.1 Applying Inorganic Nanoparticles for Imaging; 1.2 Nanoparticles' Fate in a Nutshell; 1.3 The Nanoparticle-Protein Associates. 1.4 Nanoparticle Coating: The Essential But Transient Element in Particle Stabilization and Follow-Up1.5 Cellular "Conditioning" of Administered Nanoparticles and Its Impact on Imaging Outcomes; 1.6 Different Aspects of Biotransformation: Therapeutic Properties, Loss of Functionality, and Potential Toxicity; 1.7 Material-Specific Degradation Patterns of Inorganic Nanoparticles In Vivo and Over Time; 2 Iron Oxide Nanoparticles; 2.1 Role, Effect, and Fate of IONP Synthetic (Polymer) and Biological (Corona) Coating. 2.2 Cell Internalization of IONPs and Its Effects on Nanoparticles' Magnetic Properties2.3 Degradation and Recycling of IONPs; 2.4 In Vivo Toxicity of IONPs; 3 Quantum Dots; 3.1 Cellular Processing and Fate of QDots; 3.2 Skin: The Underemphasized Organ of Nanoparticle's Accumulation; 3.3 In Vivo Toxicity of QDs; 4 Silver Nanoparticles (Ag NPs); 4.1 Therapeutic Properties and In Vivo Behavior of Ag NPs; 4.2 Toxicity of Ag NPs; 5 Gold Nanoparticles (Au NPs); 5.1 Role, Effect, and Fate of Au NPs; 5.2 Cell Internalization of Au NPs. 5.3 Long-Lasting, But Not "Eternal": The In Vivo Biopersistence of Au NPs5.4 In Vivo Toxicity of Au NPs; 6 Conclusion; References; Imaging and Therapeutic Potential of Extracellular Vesicles; 1 Introduction; 2 EV Classification and Biogenesis; 3 EV Production; 4 EV Loading; 4.1 Loading the Parent Cell Before EV Release; 4.2 Loading During EV Production; 4.3 Direct Loading or Decoration of EVs; 5 EV Isolation; 6 Characterization; 7 Engineering Vesicles for Imaging: Biodistribution Investigation; 8 Engineering Vesicles for Therapy and Theranosis; 9 Conclusions; References. Magnetic Particle Imaging1 Unmet Biomedical Imaging Needs; 2 Introduction to Magnetic Particle Imaging; 2.1 MPI Trade-Offs; 2.2 How MPI Works; 2.3 The Direct Feed-Through Challenge; 2.4 MPI Signal Is Independent of Depth; 2.5 MPI Sensitivity Is Linear, Robust, and Ideal; 2.6 MPI Resolution; 2.7 Prototype Preclinical MPI Scanners; 3 Clinical and Preclinical Applications of Magnetic Particle Imaging; 3.1 Long-Term MPI Tracking of Neural Progenitor Cells; 3.2 Dynamic, Systemic Stem Cell Tracking; 3.3 MPI Angiography Enabled by Advanced Image Reconstruction.
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2017
• Extent: 1 online resource (viii, 469 pages)
• Subjects: 610.28; Medicine; Nanoparticles -- Diagnostic use; Diagnostic imaging; Biomedical engineering; Radiology, Medical; Nanoparticles; Biomedical Engineering; Diagnostic imaging; Technology & Engineering -- Engineering (General); Medical -- Biochemistry; Biomedical engineering; Radiology; Medical -- Allied Health Services -- Medical Technology; Biomedicine; Biomedical Engineering/Biotechnology; Biomedical Engineering; Imaging / Radiology; Electronic books
• Languages: English
• ISBNs: 9783319421698; 3319421697
• Related ISBNs: 9783319421674; 3319421670
• Notes: Note: Includes bibliographical references and index.; Note: Online resource; title from digital title page (viewed on December 13, 2016).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.