Modified nucleic acids in biology and medicine. (2016)

• Record Type: Book
• Further Information: Note: Stefan Jurga, Volker A. Erdmann, Jan Barciszewski, editors.
• Editors: Jurga, Stefan; Erdmann, V. A (Volker A.), 1941-2015; Barciszewski, Jan
• Contents: Transfer RNA Modifications: from Biological Functions to Biomedical Applications -- Regulated tRNA Cleavage in Biology and Medicine: Roles of tRNA Modifications -- Sulfur-Modifications in tRNA: Function and Implications for Human Disease -- Regulation of Protein Synthesis via the Network Between Modified Nucleotides in tRNA and tRNA Modification Enzymes in Thermus thermophilus, Athermophilic Eubacterium -- Post-Transcriptional Modifications of RNA: Impact on RNA Function and Human Health -- RNA Modification N6-methyladenosine in Post-Transcriptional Regulation -- 8-Hydroxyguanine, an Oxidative DNA and RNA Modification -- Methods for Determination of 2'-O-Me in RNA -- DiadenosineTetraphosphate (Ap4A), in Health and Disease -- Thinking Small: Circulating MicroRNAs as Novel Biomarkers for Diagnosis, Prognosis and Treatment Monitoring in Breast Cancer -- Modified Antisense Oligonucleotides and their Analogs in Therapy of Neuromuscular Diseases -- Effect of Depurination on Cellular and Viral RNA -- Recognition of RNA Sequence and Structure by Duplex and Triplex Formation: Targeting miRNA and pre-miRNA -- Modifications in Therapeutic Oligonucleotides Improving the Delivery -- Interstrand Cross-Linking of Nucleic Acids: from History Towards Recent and Future Applications -- Chemical Synthesis of Lesion-Containing Oligonucleotides for DNA-Repair Studies -- Single-Molecule Visualization of Biomolecules in the Designed DNA Origami Nanostructures Using High-Speed Atomic Force Microscopy -- Polymerase Reactions that Involve Modified Nucleotides.
• Publisher Details: Switzerland : Springer
• Publication Date: 2016
• Extent: 1 online resource (xiv, 453 pages), illustrations (some color)
• Subjects: 572.8; 610; Medicine; Nucleic acids -- Biotechnology; SCIENCE -- Life Sciences -- Biochemistry; Nucleic acids -- Biotechnology; Science -- Life Sciences -- Biology -- Molecular Biology; Science -- Biotechnology; Biochemistry; Medical research; Biotechnology; Human genetics; Nucleic acids; Biotechnology; Medical -- Genetics; Medical genetics; Electronic books
• Languages: English
• ISBNs: 9783319341750; 3319341758
• Related ISBNs: 9783319341736; 3319341731
• Notes: Note: Online resource; title from PDF title page (SpringerLink, viewed August 8, 2016).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.