Apolipoprotein mimetics in the management of human disease. (2015)

• Record Type: Book
• Further Information: Note: G.M. Anantharamaiah, Dennis Goldberg, editors.
• Editors: Anantharamaiah, G. M (Gattadahalli Manjunath), 1947-; Goldberg, Dennis Ian, 1948-
• Contents: Preface; Abbreviations; Contents; Introduction; The Structure and Function of Apolipoprotein Mimetic Peptides; Bibliography; The Editors; HDL and the Amphipathic Helix; Discovery, Isolation, and Characterization of HDL; Early History of HDL Structure; Discovery of the Amphipathic Helix: An Untold Story; The Amphipathic Helix and HDL; Current History of HDL Structure; Current Thoughts on the Biomedical Implications of HDL; What Are Peptide Mimetics and Should I Care?; References; ApoA-I Mimetic Peptides: A Review of the Present Status. ApoA-I Mimetic Peptides Were Designed to Mimic a Plasma Apolipoprotein The Peptides Were Effective in a Large Number of Animal Models of Disease; The 4F Peptide Was Tested in Human Clinical Trials; Reconciling the Divergent Results from the Clinical Trials; Overcoming the Barrier of the High Cost of Production of Chemically Synthesized ApoA-I Mimetic Peptides; Determining the Mechanism of Action of Oral ApoA-I Mimetic Peptides; Other Peptides; Conclusions; References; Apolipoprotein Mimetic Peptides for Stimulating Cholesterol Efflux; Introduction; Reverse Cholesterol Transport Pathway. Apolipoprotein Mimetic PeptidesESP24218 Peptide; D-4F Peptide; L-4F Peptide; Retroinverso Peptides; 5A Peptide; ATI-5261 Peptide; Summary; References; ApoA-I Mimetic Peptides and Diabetes; Introduction; 4F Background; 4F and Diabetes; Conclusion; References; Apolipoprotein A-I Mimetic Peptides in Mouse Models of Cancer; Introduction; Inflammation and Lipoproteins in Cancer; ApoA-I and Ovarian Cancer; ApoA-I Mimetic Peptides as Cancer Therapeutics; ApoA-I Mimetic Peptides and Colon Cancer; Conclusions; References. Effects of ApoA-I Mimetic Peptide L-4F in LPS-Mediated InflammationIntroduction; LPS and Sepsis; HDL and LPS; ApoA-I and Sepsis; ApoA-I Mimetic Peptides 18A and 4F; ApoA-I Mimetic Peptide L-4F and LPS; ApoA-I Mimetic Peptide L-4F in Polymicrobial Septic Models; Efficacy of L-4F in Different Models of Atherosclerosis and Metabolic Syndrome (Diabetes) Could Be in Part Accounted for by Its Anti-endotoxin Property; References; Apolipoprotein Mimetics in the Amelioration of Respiratory Inflammation; Introduction; Genetic Deletion of ApoA-I; 4F Inhibits Airway Inflammation. Potential Mechanisms of Action Other Apolipoprotein Mimetics That Modulate Airway Inflammation; Novel Apolipoprotein Mimetics; References; Regulation of Macrophage Polarity by HDL, Apolipoproteins, and Apolipoprotein Mimetic Peptides; Introduction; Macrophage Polarization; Macrophage Heterogeneity and Atherosclerosis; HDL Composition and Function; Dysfunctional HDL; HDL-Associated S1P and Macrophage Phenotype; ABCA1 and Macrophage Polarization; HDL, Activating Transcription Factor, and Macrophage Polarization; Apolipoprotein A-I Mimetic Peptide Design.
• Publisher Details: Cham : Adis
• Publication Date: 2015
• Extent: 1 online resource, illustrations (chiefly color)
• Subjects: 572/.6; Medicine; Apolipoproteins; High density lipoproteins; Peptides; Lipids -- Metabolism; SCIENCE -- Life Sciences -- Biochemistry; Apolipoproteins; High density lipoproteins; Lipids -- Metabolism; Peptides; Apolipoproteins; Peptides; Lipid Metabolism; Medical -- Cardiology; Medical -- General; Cardiovascular medicine; Medicine: general issues; Biochemistry; Cardiology; Medical -- Biochemistry; Biochemistry; Electronic books
• Languages: English
• ISBNs: 9783319173504; 3319173502; 3319173499; 9783319173498
• Related ISBNs: 9783319173498
• Notes: Note: Includes bibliographical references.; Note: Online resource; title from PDF title page (Ebsco, viewed June 19, 2015).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.