Asymmetric synthesis of bioactive lactones and the development of a catalytic asymmetric synthesis of alpha-Aryl ketones. ([2015])

• Record Type: Book
• Further Information: Note: Robert Doran.
• Authors: Doran, Robert
• Contents: Parts of this thesis have been published in the following journal articles:; Supervisor's Foreword; Abstract; Acknowledgments; Contents; Symbols and Abbreviations; 1 Introduction to the Total Synthesis of Lactone-Containing Natural Products Using ZrCl4; 1.1 Total Synthesis of Natural Products; 1.2 Natural Products as Pharmaceuticals; 1.3 Lactone-Containing Natural Products; 1.4 Synthesis of Lactones Using ZrCl4; References; 2 Asymmetric Synthesis of the beta -Methyl-Substituted Analogues of (+)-Tanikolide and ( -- )-Malyngolide; Abstract; 2.1 Introduction; 2.2 Results and Discussion. 2.3 Biological Testing2.4 Conclusions; 2.5 Experimental Section; 2.5.1 General Experimental for All Chapters; 2.5.1.1 Materials and Methods; 2.5.1.2 Microwave Irradiation Experiments; 2.5.1.3 Instrumentation; References; 3 Asymmetric Synthesis of Both Enantiomers of a delta -Lactone Analogue of Muricatacin; Abstract; 3.1 Introduction; 3.2 Results and Discussion; 3.3 Biological Testing; 3.4 Conclusions; 3.5 Experimental; References; 4 Introduction to the Development of a Catalytic Asymmetric Synthesis of Tertiary alpha -Aryl Ketones; 4.1 Introduction. 4.2 Methods for the Synthesis of Enatiomerically Pure Compounds4.2.1 Chiral Pool; 4.2.2 Resolution; 4.2.3 Classical Resolution; 4.2.4 Kinetic Resolution; 4.2.5 Enzymatic Resolution; 4.2.6 Asymmetric Synthesis; 4.2.6.1 Chiral Reagents; 4.2.6.2 Chiral Auxiliaries; 4.2.7 Catalytic Asymmetric Synthesis; 4.2.7.1 Enzymatic Catalysis; 4.2.7.2 Organocatalysis [17]; 4.2.7.3 Transition Metal Catalysis; 4.3 Palladium-Catalysed Allylic Alkylation; 4.3.1 Carroll Rearrangement; 4.3.2 Tsuji-Trost Allylation; 4.3.3 Decarboxylative Asymmetric Allylic Allylation (DAAA); 4.3.4 Mechanism of the DAAA. 4.4 Palladium-Catalysed Decarboxylative Asymmetric Protonation (DAP)4.5 Synthesis of Isoflavanones Using DAP; 4.6 Tertiary alpha -Aryl Carbonyls; 4.7 Aryllead Triacetates; 4.7.1 Synthesis of Aryllead Triacetates; 4.7.2 Applications of Aryllead Triacetates; 4.7.2.1 C-Arylation; 4.7.3 Synthesis of Aryllead Triacetates for the C-Arylation of beta -Keto Allyl Esters; 4.8 Experimental; References; 5 A Stereoselective Switch: Enantiodivergent Approach to the Synthesis of Isoflavanones; Abstract; 5.1 Introduction; 5.2 Results and Discussion; 5.3 Conclusions; 5.4 Experimental; References. 6 Asymmetric Synthesis of Tertiary alpha -Aryl Ketones by Decarboxylative Asymmetric ProtonationAbstract; 6.1 Introduction; 6.2 Results and Discussion; 6.3 Conclusions; 6.4 Experimental; References; Appendix A X-Ray Crystal Structure Data.
• Publisher Details: Cham : Springer
• Publication Date: 2015
• Copyright Date: 2015
• Extent: 1 online resource (xxi, 202 pages)
• Subjects: 547.2; Chemistry; Asymmetric synthesis; Biosynthesis; Ketones; SCIENCE -- Chemistry -- Organic; Asymmetric synthesis; Biosynthesis; Ketones; Science -- Chemistry -- Industrial & Technical; Science -- Chemistry -- Clinical; Catalysis; Biochemistry; Chemistry, Organic; Catalysis; Biochemistry; Organic chemistry; Electronic books
• Languages: English
• ISBNs: 9783319205441; 3319205447; 3319205439; 9783319205434
• Related ISBNs: 9783319205434
• Notes: Note: Includes bibliographical references.; Note: Vendor-supplied metadata.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
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