Bioactive sphingolipids in cancer biology and therapy. (2015)

• Record Type: Book
• Further Information: Note: Yusuf A. Hannun, Chiara Luberto, Cungui Mao, Lina Marie Obeid, editors.
• Editors: Hannun, Yusuf A, 1955-; Luberto, Chiara; Mao, Cungui; Obeid, Lina Marie
• Contents: Dedication; Preface; Contents; Basics of Sphingolipid Metabolism and Signalling; 1 Introduction: Sphingolipids Are Bioactive Metabolites; 2 How Are Sphingolipids Formed, Transformed and Degraded?; 3 How Do Sphingolipids Signal and Mediate Biological Effects?; 3.1 History of Signalling Sphingolipids: Where Are We One Generation Later?; 3.2 Sphingosine 1-Phosphate: A Paradigmatic Signalling Molecule; 3.3 How Are Other Sphingolipids Bioactive?; 4 Current and Future Challenges; References; Part I: Roles and Functions of Sphingolipids in the Development of Different Types of Cancers. Role of Sphingolipids in Hematological Malignancies: Lymphoproliferative Disorders1 Introduction; 1.1 Sphingolipids in Lymphoid Cell Functions; 1.1.1 Apoptosis and the Mechanisms by Which Ceramide Induces Apoptosis; 1.1.2 Rb; 1.1.3 Ras and Raf-1; 1.1.4 Protein Kinase C; 1.1.5 Bcl-2 and Bcl-xL; 1.1.6 ROS; 1.1.7 Caspase; 1.1.8 p53; 1.1.9 Lipid Rafts; 1.1.10 Autophagy; 1.1.11 Regulated Necrosis/Necroptosis; 1.1.12 Migration; 1.1.13 Differentiation; 1.1.14 Proliferation; 1.1.15 Secretion; 1.2 Mechanisms of Ceramide Generation; 1.2.1 Acid Sphingomyelinase (ASMase) 1.2.2 Neutral Sphingomyelinase (NSMase)1.2.3 De Novo Ceramide Synthesis; 1.2.4 Sphingomyelin Synthase (SMS); 1.2.5 Glucosylceramide Synthase (GCS); 1.3 Sphingolipids Other than Ceramide in Lymphoid Cell Functions; 1.3.1 Sphingosine (Sph); 1.3.2 Sphingosine 1-Phosphate (S1P); 1.3.3 Sphingomyelin (SM); 1.3.4 GD3/GM3; 1.4 Clinical Aspects of Sphingolipids; 1.4.1 Leukemia [Acute Lymphoid Leukemia (ALL) and Chronic Lymphoid Leukemia (CLL)]; 1.4.2 Malignant Lymphoma; 1.4.3 Multiple Myeloma; 2 Concluding Remarks; References. Role of Sphingolipids in Hematological Malignancies: Myeloproliferative Disorders1 Introduction; 1.1 Myeloproliferative Neoplasms (MPNs); 1.1.1 Chronic Myelogenous Leukemia, BCR-ABL1 Positive (CML); Role of Sphingolipids in CML; 1.1.2 Sphingolipids and Other MPNs; 1.2 Myelodysplastic Syndrome (MDS); 1.3 Acute Myeloid Leukemia (AML) and Other Related Neoplasms; 1.3.1 Sphingolipids and Regulation of Differentiation of AML Cells and Other Cell Models of Related Neoplasms; 1.3.2 Sphingolipids and Regulation of Apoptosis in AML Cells; 2 Conclusions; References. Sphingolipids as Mediators of Breast Cancer Progression, Metastasis, Response and Resistance to Chemotherapy1 Introduction to Breast Cancer; 2 Molecular Genetic Portraits of Breast Cancer; 3 Sphingolipids in Breast Cancer; 4 Sphingolipids in Luminal Type Breast Cancers; 4.1 Glucosylceramide Transferase; 4.2 The Ceramide Synthases; 4.3 The Sphingomyelinases; 4.4 The Ceramidases; 4.5 The Sphingosine Kinases; 4.6 Ceramide Kinase; 5 Sphingolipids in Basal Type Breast Cancer; 6 Sphingolipids in Her2-Like Breast Cancer; 7 Conclusions; References; Role of Sphingolipids in Non-melanoma Skin Cancer.
• Publisher Details: Cham : Springer
• Publication Date: 2015
• Extent: 1 online resource (xi, 490 pages), illustrations (some color)
• Subjects: 572/.57; Medicine; Sphingolipids; Cancer -- Molecular aspects; Cancer -- Treatment; SCIENCE -- Life Sciences -- Biochemistry; Cancer -- Molecular aspects; Cancer -- Treatment; Sphingolipids; Biomedicine; Cancer Research; Biochemistry, general; Laboratory Medicine; Neoplasms -- therapy; Medical -- Laboratory Medicine; Biochemistry; Medical laboratory testing & techniques; Oncology; Biochemistry; Medical laboratories; Medical -- Oncology; Oncology; Electronic books; Electronic books
• Languages: English
• ISBNs: 9783319207506; 3319207504; 3319207490; 9783319207490
• Related ISBNs: 9783319207490
• Notes: Note: Online resource; title from PDF title page (SpringerLink, viewed September 2, 2015).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.