Chromosomal translocations and genome rearrangements in cancer. ([2015])

• Record Type: Book
• Further Information: Note: Janet D. Rowley, Michelle M. Le Beau, Terence H. Rabbitts, editors.
• Editors: Rowley, Janet D; Le Beau, Michelle M; Rabbitts, T. H (Terry H.)
• Contents: Part I Introduction -- A short history of chromosome rearrangements and gene fusions in cancer -- Part II General -- Molecular genetics methods in discovery of chromosome structure -- Mechanism of recurrent chromosomal translocations -- Chromosome translocations, cancer initiation and clonal evolution.- Chromosomal fragile sites and cancer -- Copy number changes in carcinomas: applications -- Part III LEUKAEMIA/LYMPHOMA -- Chronic myeloid leukaemia -- Immunoglobulin and MYC rearrangements in multiple myeloma pathogenesis -- Genetic alterations in B cell lymphoma -- Chromosomal translocations and gene rearrangements in acute lymphoblastic leukaemia -- Cellular and molecular basis of MLL leukaemias: from transformation mechanisms to novel therapeutic strategies -- Acute promyelocytic leukaemia: from a specific translocation to cure by targeted therapies -- Chromosome Abnormalities in AML and their clinical importance -- PART IV SARCOMAS -- Fusion Oncogenes of Sarcomas -- Translocations in Ewing Sarcoma -- PART V EPITHELIAL TUMOURS -- RET and thyroid carcinomas -- Gene fusions in prostate cancer -- Chromosomal Translocations in Lung Cancer -- Colon & Ovarian translocations -- PART VI OTHER ASPECTS -- Pre-clinical modeling of chromosomal translocations and inversions -- Protein complex hierarchy & translocation gene products -- Aberrant transcriptional programming in blood cancers -- Index.
• Publisher Details: Cham : Springer
• Publication Date: 2015
• Copyright Date: 2015
• Extent: 1 online resource (ix, 490 pages), illustrations (some color)
• Subjects: 616.99/4; Medicine; Cancer -- Genetic aspects; HEALTH & FITNESS -- Diseases -- General; MEDICAL -- Clinical Medicine; MEDICAL -- Diseases; MEDICAL -- Evidence-Based Medicine; MEDICAL -- Internal Medicine; Cancer -- Genetic aspects; Biomedicine; Cancer Research; Cell Biology; Human Genetics; Molecular Medicine; Neoplasms -- genetics; Science -- Life Sciences -- Biology -- Molecular Biology; Medical -- Genetics; Cellular biology (cytology); Medical genetics; Medical research; Oncology; Cytology; Human genetics; Medical -- Oncology; Oncology; Electronic books
• Languages: English
• ISBNs: 9783319199832; 3319199838; 9783319199825
• Related ISBNs: 331919982X; 9783319199825
• Notes: Note: Online resource; title from PDF title page (SpringerLink, viewed December 15, 2015).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.